Results 81 to 90 of about 3,462 (201)
Knockdown of FBG1 in HepG2 cells increases levels of endogenous A1AT.
, 2015 A) Transient transfection of shRNAs against FBG1 in Cos-7 cells. B) Stable HepG2 clones were selected after infection with FBG1-knockdown lentivirus. Total cell lysates were separated on SDS-PAGE gels and probed with antibodies against FBG1, A1AT, and ...
Kevin A. Glenn (785982) +3 more
core +1 more source
Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia
Archives of Medicine and Health Sciences, 2019 Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa +2 more
doaj +1 more source
Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling +9 more
wiley +1 more source
Details of the 2-D patterns of the candidate substrate A1AT incubated with HTRA1.
, 2014 Details of the 2-D pattern of the HTRA1 substrate A1AT in the placenta protein sample after incubation in the absence (−HTRA1) and in the presence (+HTRA1) of HTRA1 (A). The images are small sections of the Figure 2.
Violette Frochaux (647168) +4 more
core +1 more source
IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI [PDF]
, 2016 Several splice variants of IgE exist in human plasma, including a variant called IgE-tailpiece (IgE-tp) that differs from classical IgE by the replacement of two carboxy-terminal amino acids with eight novel residues that include an ultimate cysteine. To
Dunne, David W. +3 more
core +1 more source
Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Journal of Neuroinflammation, 2018 Background Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal cells.
Taraneh Ebrahimi +8 more
doaj +1 more source
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Secretory pathways leading to A1AT transcytosis across cultured pulmonary endothelial monolayers.
, 2014 (A–D) Immunoblot showing effect of inhibition of classical secretory pathway with tunicamycin (A–C; at the indicated doses; 18 h) or brefeldin A (D; 1 µg/mL, 60 min) on intracellular A1AT (A, B, D) and secretion of A1AT (A, C) detected by Western ...
Houssam Oueini (553977) +13 more
core +1 more source
Inhibition of autophagy by Beclin1 siRNA inhibits FBG1-mediated clearance of A1AT-Z.
, 2015 A) Hepa1-6 cells stably selected after transfection with siLuciferase or siBeclin1. B) ImageJ analysis of A1AT-Z levels normalized to total protein. C) Table showing levels of normalized values for A1AT-Z and p62 levels.
Kevin A. Glenn (785982) +3 more
core +1 more source