Results 101 to 110 of about 3,462 (201)

A1AT is ineffective on endogenous caspase-1 activation in cell-free system.

, 2015
Caspase-1 activity was measured in cell-free lysates from THP-1 monocytes. Cell-free lysates in a hypotonic buffer were placed at 4 or 30°C for 1 hour with or without A1AT (2.5 mg/mL). Same concentration of BSA was used as control. Caspase-1 activity was
Srabani Mitra (259173), Anasuya Sarkar (259171), Mohd. Akhlakur Rahman (540814), Mark D. Wewers (94894)   +3 more
core   +1 more source

ROC Analysis of Diagnostic Performance Utilizing Serum Antiproteases in Cancer Patients

The International Journal of Biological Markers, 1988
Assessment of the accuracy of diagnostic procedures is made independent of diagnostic criteria by means of a receiver-operating-characteristics (ROC) curve. We performed ROC analysis for the major serum antiproteases: alpha-1-antitrypsin (A1AT) and alpha-
J. Millán, A. Lorenzo, P. Gallurt, P. Rodriguez, J. Romero, J.J.B. López, A. Senra   +6 more
doaj   +1 more source

TEMPORAL AND TISSUE-SPECIFIC EXPRESSION OF THE MET ORF DRIVEN BY THE COMPLETE TRANSCRIPTIONAL UNIT OF HUMAN A1AT GENE IN TRANSGENIC MICE

, 1995
We inserted the sequence coding for the cytoplasmic portion of the human MET receptor into an 18-kb genomic fragment containing the entire human A1AT gene (encoding alpha-1-antitrypsin).
AMICONE, Laura, Veronica De Luca, Galimi, M.A., Spagnoli, F.M., Cristina Tommasini, TRIPODI, Marco, Michele Alessandro Galimi, De Luca, V., Tommasini, C., Francesca Maria Spagnoli, Tripodi, M., Amicone, L.   +11 more
core   +1 more source

The patient profile of individuals with Alpha-1 antitrypsine gene mutations at a referral center in Brazil

Jornal Brasileiro de Pneumologia
Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil.
Manuela Brisot Felisbino, Frederico Leon Arrabal Fernandes, Maria Cecília Nieves Maiorano de Nucci, Regina Maria de Carvalho Pinto, Emilio Pizzichini, Alberto Cukier   +5 more
doaj   +1 more source

A1AT does not influence IL-18 processing and release through the activation of caspase-1.

, 2015
THP-1 cells and human monocytes were pre-treated with A1AT (2.5 mg/mL) for 1 h followed by LPS 1 μg/ml for 30 minutes, and then triggered with ATP 5 mM for another 30 minutes to determine the release of IL-18 and caspase-1.
Srabani Mitra (259173), Anasuya Sarkar (259171), Mohd. Akhlakur Rahman (540814), Mark D. Wewers (94894)   +3 more
core   +1 more source

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency

Biologics: Targets & Therapy, 2009
Caitriona McLean*, Catherine M Greene*, Noel G McElvaneyRespiratory Research Division, Dept. Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland; *Each of these authors contributed equally ...
Caitriona McLean, Catherine M Greene, Noel G McElvaney   +2 more
doaj  

Effects of alpha1 antitrypsin (A1AT) on lung inflammation and Pseudomonas aeruginosa (PA) load in wild-type mice after 1 day of infection.

, 2015
Mice were infected with PA as described in Materials and Methods, and treated at 2 h post PA infection with A1AT. After 1 day of PA infection, mice (n = 6 mice/group) were sacrificed to determine inflammation (A, B, C, D) and PA load (E, F) in ...
Di Jiang (258208), Hong Wei Chu (193512), Reena Berman (452713), David P. Nichols (196771), Carrie Happoldt (692046)   +4 more
core   +1 more source

Effects of alpha1 antitrypsin (A1AT) on SPLUNC1 protein levels in bronchoalveolar lavage (BAL) fluid of wild-type and ENaC transgenic (Tg) mice after 3 days of infection.

, 2015
Mice were infected with Pseudomonas aeruginosa (PA) as described in Materials and Methods, and treated at 2 hr, 1 day and 3 day post PA infection with A1AT.
Di Jiang (258208), Hong Wei Chu (193512), Reena Berman (452713), David P. Nichols (196771), Carrie Happoldt (692046)   +4 more
core   +1 more source

α1-Antitrypsin (SERPINA1; AAT; A1AT) [PDF]

Science-Business eXchange, 2010
openaire   +2 more sources

Effects of alpha1 antitrypsin (A1AT) on lung inflammation and Pseudomonas aeruginosa (PA) load in ENaC transgenic mice after 3 days of infection.

, 2015
Mice were infected with PA as described in Materials and Methods, and treated at 2 hr, 1 day and 3 day post PA infection with A1AT. After 3 days of PA infection, mice (n = 6–7 mice/group) were sacrificed to determine inflammation (A, B, C, D) and PA load
Di Jiang (258208), Hong Wei Chu (193512), Reena Berman (452713), David P. Nichols (196771), Carrie Happoldt (692046)   +4 more
core   +1 more source