Results 31 to 40 of about 10,966 (204)

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Development of a MALDI MS-based platform for early detection of acute kidney injury [PDF]

, 2016
Purpose: Septic acute kidney injury (AKI) is associated with poor outcome. This can partly be attributed to delayed diagnosis and incomplete understanding of the underlying pathophysiology.
Albalat, Albrethsen, Albrethsen, Ali, Amdur, Bagshaw, Basile, Bellomo, Bouchard, Breen, Chawla, Chertow, Coca, Coca, Davidman, Doi, Endre, Gaieski, Garner, Geus, Giebel, Glorieux, Goldstein, Good, Greenwel, Ho, Ishani, Iskander, Kim, Liu, Metzger, Molin, Okada, Schaub, Schrier, Theodorescu, Vanmassenhove, Vincent, Wald, Wan, Wiedemann, Zarjou, Zhao   +42 more
core   +2 more sources

Key inflammatory pathway activations in the MCI stage of Alzheimer's disease [PDF]

, 2019
OBJECTIVE: To determine the key inflammatory pathways that are activated in the peripheral and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease (AD).
Bekris, Lynn M., Bena, James, Chance, Mark, Lamb, Bruce T., Leverenz, James B., Maxwell, Sean, Pillai, Jagan A., Rao, Stephen M.   +7 more
core   +2 more sources

Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. [PDF]

, 2017
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced ...
Baye, Fitsum, Goswami, Chirayu Pankaj, Gurung, Ganga, Jackson, Isabel L., Katz, Barry P., Pavlovic, Radmila, Vujaskovic, Zeljko, Winans, Don, Zodda, Andrew   +8 more
core   +4 more sources

Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers [PDF]

, 2007
SummaryObjectiveMesenchymal stem cells (MSCs) are a population of cells broadly discussed to support cartilage repair. The differentiation of MSCs into articular chondrocytes is, however, still poorly understood on the molecular level.
Boeuf, S., Steck, E., Pelttari, K., Hennig, T., Buneß, A., Benz, K., Witte, D., Sültmann, H., Poustka, A., Richter, W.   +9 more
core   +1 more source

α1-Antitrypsin deficiency. [PDF]

, 2016
α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes underdiagnosed or misdiagnosed as asthma, chronic obstructive pulmonary disease ...
Brantly, Mark L, Ferrarotti, Ilaria, Greene, Catherine M, Lomas, David A, Marciniak, Stefan J, McElvaney, Noel G, Stoller, James K, Teckman, Jeffrey   +7 more
core   +2 more sources

Genetic diagnosis of α1-antitrypsin deficiency using DNA from buccal swab and serum samples [PDF]

, 2017
Background: α1-Antitrypsin deficiency (AATD) is associated with a high risk of developing lung and liver disease. Despite being one of the most common hereditary disorders worldwide, AATD remains under-diagnosed and prolonged delays in diagnosis are ...
Barrecheguren, Miriam, Belmonte, Irene, Esquinas López, Cristina, Miravitlles Fernández, Marc, Rodriguez-Frias, Francisco, Rodríguez, Esther   +5 more
core   +1 more source

Tissue-specific gene silencing monitored in circulating RNA [PDF]

, 2013
Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene ...
Bumcrot, David A., Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W. Y., Sehgal, Alfica   +4 more
core   +1 more source

SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1

PLoS ONE, 2013
Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. The SERPIN cluster located at the 14q32.1 region includes the gene coding for SERPINA1, and a highly homologous sequence, SERPINA2, which was originally thought to be a ...
Marques, Patrícia Isabel, Ferreira, Zélia, Martins, Manuella, Figueiredo, Joana, Silva, Diana Isabel, Castro, Patrícia, Morales-Hojas, Ramiro, Correia, Joana Simões, Seixas, Susana   +8 more
openaire   +5 more sources

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading cause of LBP.
Xiao Yang, Yang Lu, Hang Zhou, Hai-Tao Jiang, Lei Chu   +4 more
doaj   +1 more source