Results 31 to 40 of about 6,824 (156)

Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells

Frontiers in Endocrinology, 2022
Endometriosis is characterized by the presence of inflamed and fibrotic endometrial tissue outside the uterine cavity. Previously, we found decreased SERPINA1 (alpha-1 antitrypsin) expression in endometriosis-like lesions in a mouse model of ...
Kazuya Kusama, Ayaka Satoyoshi, Mana Azumi, Mikihiro Yoshie, Junya Kojima, Yumi Mizuno, Masanori Ono, Hirotaka Nishi, Takeshi Kajihara, Kazuhiro Tamura   +9 more
doaj   +1 more source

SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1

PLoS ONE, 2013
Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. The SERPIN cluster located at the 14q32.1 region includes the gene coding for SERPINA1, and a highly homologous sequence, SERPINA2, which was originally thought to be a ...
Marques, Patrícia Isabel, Ferreira, Zélia, Martins, Manuella, Figueiredo, Joana, Silva, Diana Isabel, Castro, Patrícia, Morales-Hojas, Ramiro, Correia, Joana Simões, Seixas, Susana   +8 more
openaire   +5 more sources

Alternative transcripts of the SERPINA1 gene in alpha-1 antitrypsin deficiency [PDF]

Journal of Translational Medicine, 2015
SERPINA1 is the gene for alpha-1 antitrypsin (AAT), an acute phase protein with anti-protease and immunoregulatory activities. Mutations in SERPINA1 gene cause AAT deficiency and predispose individuals to early-onset emphysema and liver diseases. Expression of the SERPINA1 gene is regulated by different promoters and alternative splicing events among ...
Matamala N., Martinez M. T., Lara B., Perez L., Vazquez I., LOZANO JIMENEZ, ANDRES, Barquin M., Ferrarotti I., Blanco I., Janciauskiene S., Martinez-Delgado B.   +10 more
openaire   +4 more sources

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading cause of LBP.
Xiao Yang, Yang Lu, Hang Zhou, Hai-Tao Jiang, Lei Chu   +4 more
doaj   +1 more source

Identification of SERPINA1 promoting better prognosis in papillary thyroid carcinoma along with Hashimoto’s thyroiditis through WGCNA analysis

Frontiers in Endocrinology, 2023
BackgroundHashimoto’s thyroiditis (HT) is an autoimmune thyroid disease. Papillary thyroid carcinoma (PTC) is the most common endocrine cancer. In recent years the rate of coexistence between PTC and HT has increased but the relationship between them ...
Yihan Zhang, Xin Xie, Hong Zhou, Bingxin Li, Li Ding, Zhaogen Cai, Huaidong Song, Shuangxia Zhao, Huanbai Xu   +8 more
doaj   +1 more source

The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

American Journal of Respiratory and Critical Care Medicine, 2020
Abstract Rationale The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, member 1), in determining chronic obstructive pulmonary disease risk and severity is ...
Ortega, Victor E, Li, Xingnan, O’Neal, Wanda K, Lackey, Lela, Ampleford, Elizabeth, Hawkins, Gregory A, Grayeski, Philip J, Laederach, Alain, Barjaktarevic, Igor, Barr, R Graham, Cooper, Christopher, Couper, David, Han, MeiLan K, Kanner, Richard E, Kleerup, Eric C, Martinez, Fernando J, Paine, Robert, Peters, Stephen P, Pirozzi, Cheryl, Rennard, Stephen I, Woodruff, Prescott G, Hoffman, Eric A, Meyers, Deborah A, Bleecker, Eugene R, Alexis, Neil E, Anderson, Wayne H, Arjomandi, Mehrdad, Bateman, Lori A, Bhatt, Surya P, Boucher, Richard C, Bowler, Russell P, Christenson, Stephanie A, Comellas, Alejandro P, Criner, Gerard J, Crystal, Ronald G, Curtis, Jeffrey L, Doerschuk, Claire M, Dransfield, Mark T, Freeman, Christine M, Galban, Craig, Hansel, Nadia N, Hastie, Annette T, Huang, Yvonne, Kaner, Robert J, Krishnan, Jerry A, LaVange, Lisa M, Lazarus, Stephen C, Moore, Wendy C, Paulin, Laura, Putcha, Nirupama, Oelsner, Elizabeth C, Raman, Sanjeev, Tashkin, Donald P, Wells, J Michael, Wise, Robert A   +54 more
openaire   +5 more sources

Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients

International Journal of General Medicine, 2022
David Nygren,1 Ulrica Mölstad,2 Hans Thulesius,2– 4 Magnus Hillman,5,6 Lars Mikael Broman,7,8 Hanan Tanash,9,10 Mona Landin-Olsson,5,6 Magnus Rasmussen,1 Maria Thunander2,6,11 1Division of Infection Medicine, Department of Clinical Sciences, Lund ...
Nygren D, Mölstad U, Thulesius H, Hillman M, Broman LM, Tanash H, Landin-Olsson M, Rasmussen M, Thunander M   +8 more
doaj  

Serpina1 (α1-AT) is synthesized in the osteoblastic stem cell niche

Experimental Hematology, 2009
Previously, we identified Serpina1 as a potent inhibitor of hematopoietic stem and progenitor cell (HSC/HPC) mobilization. Serpina1 protein is found in the bone marrow (BM) extracellular fluid and concentrations are decreased during granulocyte colony-stimulating factor-induced HSC/HPC mobilization in mice.
Kuiperij, H.B., Pel, M. van, Rooij, K.E. de, Hoeben, R.C., Fibbe, W.E.   +4 more
openaire   +3 more sources

Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. [PDF]

PLoS ONE, 2013
The serine protease inhibitor, clade A, member 1 (SERPINA1) is the gene for a protein called alpha-1-antitrypsin (AAT), which is a member of the serine protease inhibitor (serpin) superfamily of proteins. By conformational change, serpins control several
Cinzia Marchitelli, Alessandra Crisà, Elisa Mostarda, Francesco Napolitano, Bianca Moioli   +4 more
doaj   +1 more source

SerpinA1 levels in amyotrophic lateral sclerosis patients: An exploratory study

European Journal of Neurology, 2023
AbstractBackgroundSerpinA1, a serine protease inhibitor, is involved in the modulation of microglial‐mediated inflammation in neurodegenerative diseases. We explored SerpinA1 levels in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients to understand its potential role in the pathogenesis of the disease.MethodsSerpinA1 ...
Martinelli, Ilaria, Zucchi, Elisabetta, Simonini, Cecilia, Gianferrari, Giulia, Bedin, Roberta, Biral, Chiara, Ghezzi, Andrea, Fini, Nicola, Carra, Serena, Mandrioli, Jessica   +9 more
openaire   +2 more sources