Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. [PDF]
PLoS ONE, 2013 The serine protease inhibitor, clade A, member 1 (SERPINA1) is the gene for a protein called alpha-1-antitrypsin (AAT), which is a member of the serine protease inhibitor (serpin) superfamily of proteins. By conformational change, serpins control several
Cinzia Marchitelli +4 more
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Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. [PDF]
, 2018 Engineering of the Cpf1 crRNA has the potential to enhance its gene editing efficiency and non-viral delivery to cells. Here, we demonstrate that extending the length of its crRNA at the 5 end can enhance the gene editing efficiency of Cpf1 both in cells
Chong, Anthony +10 more
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Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia [PDF]
, 2020 BackgroundCritical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply.
A Carrizzo +82 more
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European Journal of Neurology, 2023 AbstractBackgroundSerpinA1, a serine protease inhibitor, is involved in the modulation of microglial‐mediated inflammation in neurodegenerative diseases. We explored SerpinA1 levels in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients to understand its potential role in the pathogenesis of the disease.MethodsSerpinA1 ...
Martinelli, Ilaria +9 more
openaire +2 more sources
Non melanoma skin cancer pathogenesis overview [PDF]
, 2018 (1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo +3 more
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SERPINA1 gene identified in RNA-Seq showed strong association with milk protein concentration in Chinese Holstein cows [PDF]
PeerJ, 2020 The detection of candidate genes and mutations associated with phenotypic traits is important for livestock animals. A previous RNA-Seq study revealed that SERPINA1 gene was a functional candidate that may affect milk protein concentration in dairy cows.
Cong Li +6 more
doaj +2 more sources
Innate immune response is differentially dysregulated between bipolar disease and schizophrenia [PDF]
, 2015 Articles in PressSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies
Barreta, Luiz André Nardin +10 more
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DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD [PDF]
, 2017 Background: Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs
Baier, Brian S. +7 more
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Respiratory Medicine Case Reports, 2023 Background: The clinical and molecular characteristics of three patients with previously unreported SERPINA1 mutations associated with severe alpha-1 antitrypsin deficiency (AATD) are described.
Philipp Höger +10 more
doaj +1 more source
The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency. [PDF]
, 2011 The serine proteinase inhibitor α-1 anti-trypsin (AAT) provides an antiprotease protective screen throughout the body. Mutations in the AAT gene (SERPINA1) that lead to deficiency in AAT are associated with chronic obstructive pulmonary diseases.
Greene, Catherine M +3 more
core +2 more sources