Results 51 to 60 of about 6,824 (156)

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

PLoS Genetics, 2021
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in COPD
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach   +15 more
doaj   +1 more source

Genetic Alterations in the SERPIN Gene Family as Predictors of Immune Checkpoint Therapy Efficacy in Melanoma and Non‐Small Cell Lung Cancer

Medicine Advances, EarlyView.
This study demonstrated a clear association between serine protease inhibitor (SERPIN) gene alterations and clinical outcomes in patients with melanoma and non‐small cell lung cancer receiving immune checkpoint inhibitor therapy across five cohorts.
Jieqiong Li, Di Wang, Yuxin Wang, Lixia Wang, Jinmei Luo, Yi Xiao   +5 more
wiley   +1 more source

miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease

Archivos de Bronconeumología, 2021
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting in lung and liver disease with a great clinical variability. MicroRNAs have been identified as disease modifiers; therefore miRNA deregulation could play an important role in disease heterogeneity.
Matamala, Nerea, Lara, Beatriz, Gomez-Mariano, Gema Maria, Martinez Rodríguez, Selene, Vazquez-Dominguez, Irene, Otero-Sobrino, Álvaro, Muñoz-Callejas, Antonio, Sánchez, Elena, Esquinas, Cristina, Bustamante, Ana, Cadenas, Sergio, Curi, Sergio, Lázaro, Lourdes, Martínez, María Teresa, Rodríguez, Esther, Miravitlles, Marc, Torres-Durán, María, Herrero, Inés, Michel, Francisco Javier, Castillo, Silvia, Hernández-Pérez, José Mª, Blanco, Ignacio, Casas, Francisco, Martinez-Delgado, Beatriz   +23 more
openaire   +7 more sources

Prognostic Value of SERPINA1 as a Biomarker for Poor Survival of Gliomas

Journal of Medical Sciences
Background: Glioma is a primary brain tumor known for its aggressive behavior and poor prognosis. Alpha-1 antitrypsin (SERPINA1) is a protein with a crucial role in regulating inflammatory processes in the body.
Nai-Jui Cheng, Hao-Yuan Hung, Tzu-Tsao Chung, Wen-Shin Song, Kun-Ting Hong, Dueng-Yuan Hueng   +5 more
doaj   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease

Genetics and Molecular Biology, 2008
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1) deficiency is one of the main genetic causes related to liver disease in children. In SERPINA1 deficiency the most frequent SERPINA1 alleles found are the PI*S
Guilherme Baldo, Ana Ayala, Matias Melendez, Karina Nonnemacher, Luciane Lima, Sandra Leistner Segal, Carlos Kieling, Sandra Gonçalves Vieira, Cristina Targa Ferreira, Themis Reverbel da Silveira, Roberto Giugliani, Ursula Matte   +11 more
doaj   +1 more source

Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition

Acta Paediatrica, EarlyView.
ABSTRACT Aims and Methods Advances in neonatal care have extended borderline survival to 22–24 post‐conceptional weeks. Present review discusses approaches for prolonging short pregnancies and prevention of serious morbidities in extremely premature infants born before 28 weeks of pregnancy.
Mikko Hallman
wiley   +1 more source

A Novel SERPINA1 Mutation Causing Serum Alpha1-Antitrypsin Deficiency

PLoS ONE, 2012
Mutations in the SERPINA1 gene can cause deficiency in the circulating serine protease inhibitor α(1)-Antitrypsin (α(1)AT). α(1)AT deficiency is the major contributor to pulmonary emphysema and liver disease in persons of European ancestry, with a prevalence of 1 in 2500 in the USA.
Darren N Saunders, Elizabeth A Tindall, Robert F Shearer, Jacquelyn Roberson, Amy Decker, Jean Amos Wilson, Vanessa M Hayes   +6 more
openaire   +4 more sources

Heterozygous Genotype rs17580 AT (PiS) in SERPINA1 is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case–Control and Populational Study

International Journal of COPD, 2020
Gloria Pérez-Rubio,1 Enrique Ambrocio-Ortiz,1 Luis A López-Flores,1 Ana I Juárez-Martín,2 Luis Octavio Jiménez-Valverde,1 Susana Zoreque-Cabrera,1 Gustavo Galicia-Negrete,1 María Elena Ramírez-Díaz ...
Pérez-Rubio G, Ambrocio-Ortiz E, López-Flores LA, Juárez-Martín AI, Jiménez-Valverde LO, Zoreque-Cabrera S, Galicia-Negrete G, Ramírez-Díaz ME, Cruz-Vicente F, Castillejos-López MJ, Salinas-Lara C, Hernández-Zenteno RJ, Ramírez-Venegas A, Falfán-Valencia R   +13 more
doaj  

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Respiratory Research, 2018
Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Probst-Hensch   +22 more
doaj   +1 more source