Results 71 to 80 of about 8,184 (185)

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Respiratory Research, 2018
Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Probst-Hensch   +22 more
doaj   +1 more source

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2605-2612, October 2026.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source

Acupuncture Attenuates Neuroinflammation Following Acute Cerebral Infarction by Downregulating SPP1 to Ameliorate Immunological Niches

Brain and Behavior, Volume 16, Issue 9, September 2026.
The study workflow and key mechanistic findings are illustrated. In cohort 1, serum samples from acute cerebral infarction (ACI) patients and healthy controls were screened using proteomics to identify differentially expressed proteins. In cohort 2, the therapeutic effects of acupuncture on ACI were further validated.
Jiang‐Peng Cao, Xiao‐Xi Liu, Ling‐Fei Wang, Ying Zhou, Lin Zhang, Xu‐Juan Chen, Yue‐Xin Lin, Lin‐Ling Chen, Yuan‐Hao Du   +8 more
wiley   +1 more source

Additional file 1 of Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth

, 2022
Additional file 1: FigS1. Representative 2D gel of human placental tissue after spontaneous preterm birth. FigS2. Densitometric evaluation of western blot of alpha-1 antitrypsin and tubulin α-1B. FigS3.
Mika Rämet (133146), Johanna M. Huusko (11542689), Antti M. Haapalainen (6836669), Ulrich Bergmann (115067), Louis J. Muglia (7841168), Pinja Tissarinen (12470656), Steffen Ohlmeier (611105), Anu Pasanen (6836672), Marja Ojaniemi (230956), Mikko Hallman (114373), Tomi A. Määttä (12470659), Heli Tiensuu (6836666)   +11 more
core   +1 more source

Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression

Nature Communications
Lipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, we show that serine protease inhibitor A1 (SerpinA1) expression in the liver is increased during recovery from ...
Shota Okagawa, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata, Tatsuya Kondo, Naoki Takeda, Kimi Araki, Bruna Brasil Brandao, Wei-Jun Qian, Yu-Hua Tseng, Rohit N. Kulkarni, Naoto Kubota, C. Ronald Kahn, Eiichi Araki   +14 more
doaj   +1 more source

Heterozygous Genotype rs17580 AT (PiS) in SERPINA1 is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case–Control and Populational Study

International Journal of COPD, 2020
Gloria Pérez-Rubio,1 Enrique Ambrocio-Ortiz,1 Luis A López-Flores,1 Ana I Juárez-Martín,2 Luis Octavio Jiménez-Valverde,1 Susana Zoreque-Cabrera,1 Gustavo Galicia-Negrete,1 María Elena Ramírez-Díaz ...
Pérez-Rubio G, Ambrocio-Ortiz E, López-Flores LA, Juárez-Martín AI, Jiménez-Valverde LO, Zoreque-Cabrera S, Galicia-Negrete G, Ramírez-Díaz ME, Cruz-Vicente F, Castillejos-López MJ, Salinas-Lara C, Hernández-Zenteno RJ, Ramírez-Venegas A, Falfán-Valencia R   +13 more
doaj  

Method Matters: A Proteomics‐Informed Framework for Selecting Extracellular Vesicle Isolation Methods for Plasma

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
This study evaluated 11 extracellular vesicle (EV) isolation methods which generate plasma‐derived EV‐containing preparations with varying degrees of contaminants. No single approach optimized purity and proteome coverage. In this paper we use proteomics to present an Evidence‐Based Framework to select plasma EV isolation methods based on downstream ...
Scheila Julia Werle, Marie Louise Nautrup Therkelsen, Chen Meng, Mads Grønborg, Lise Lotte Gluud, Dres Damgaard   +5 more
wiley   +1 more source

The use of real-time PCR for the diagnosis of Z gene Pi mutation in patients with alpha-1 antitrypsin deficiency

Якутский медицинский журнал
The aim of this study is to develop a method for diagnosing PiZ mutation associated with alpha-1 antitrypsin deficiency using real-time PCR technology.A simple method is proposed for detecting one of the most frequent mutations of the Pi gene PiZ ...
E. V. Tapiev, A. Yu. Asanov, O. I. Simonova, A. L. Sukhomyasova, K. K. Pavlova, I. Yu. Chebelyaev   +5 more
doaj   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Tunable Fabrication of 2D‐Layered Magnesium Nanosilicates With Hemostatic Properties

Small Science, Volume 6, Issue 9, September 2026.
Tunable 2D magnesium nanosilicates form bioactive protein coronas, support cellular internalization, and promote hemostatic activity. These nanoclays enable shear‐thinning gel formation and reduce clotting time and blood loss, highlighting their potential for wound‐management applications. Tunable fabrication of inorganic two‐dimensional (2D) nanoclays
Anna L. Keller, Kanwar Abhay Singh, Saptarshi Biswas, Kavita Kadu, Sarah E. Miller, Weijian Hua, Sridevi Conjeevaram, Vaaridhi Ramanuja, Shounak Roy, Samantha Foster, Changwoo Do, Wei‐Ren Chen, Yifei Jin, Akhilesh K. Gaharwar   +13 more
wiley   +1 more source