Results 81 to 90 of about 8,184 (185)

Haplotype-Aware Detection of SERPINA1 Variants by Nanopore Sequencing

The Journal of Molecular Diagnostics
α-1 Antitrypsin (AAT) is an acute-phase reactant with immunomodulatory properties that mainly inhibits neutrophil elastase. Low serum levels cause AAT deficiency (AATD), an underdiagnosed condition that predisposes to pulmonary and hepatic diseases. The SERPINA1 gene, which encodes AAT, contains >500 variants.
Mario A. González-Carracedo, Esther Herrera-Luis, María Marco-Simancas, Ainhoa Escuela-Escobar, Elena Martín-González, Olaia Sardón-Prado, Paula Corcuera, Jose M. Hernández-Pérez, Fabián Lorenzo-Díaz, José A. Pérez-Pérez   +9 more
openaire   +3 more sources

SERPINA1 and HSD17B13 Gene Variants in Patients with Liver Fibrosis and Cirrhosis

Journal of Gastrointestinal and Liver Diseases, 2019
Background & Aims: Two single nucleotide polymorphisms (SNPs) in SERPINA1 (Pi*Z rs28929474 and Pi*Srs17580) are risk factors for developing liver cirrhosis. A recent study identified a common SNP in HSD17B13(rs72613567) that conferred protection from chronic liver disease.
Viktorija, Basyte-Bacevice, Jurgita, Skieceviciene, Irena, Valantiene, Jolanta, Sumskiene, Vitalija, Petrenkiene, Jurate, Kondrackiene, Dalius, Petrauskas, Frank, Lammert, Juozas, Kupcinskas   +8 more
openaire   +3 more sources

Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition

Acta Paediatrica, Volume 115, Issue 9, Page 1847-1860, September 2026.
ABSTRACT Aims and Methods Advances in neonatal care have extended borderline survival to 22–24 post‐conceptional weeks. Present review discusses approaches for prolonging short pregnancies and prevention of serious morbidities in extremely premature infants born before 28 weeks of pregnancy.
Mikko Hallman
wiley   +1 more source

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Exploration, Volume 6, Issue 4, August 2026.
Obesity‐linked hypercoagulation is driven by fibrinogen overproduction in a specific hepatocyte cluster via IL6 signalling. Genetic and mechanistic studies reveal this pathway as a key target for therapies to mitigate clotting risks and associated complications in obese individuals.
Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng, Ziyi Yang, Yue Liu, Yonghui Jiang, Tao Zhu, Teng Liu, Yunfei Xu, Chang Pan, Han Zhao, Shaozhuang Liu, Shigang Zhao, Zi‐Jiang Chen   +14 more
wiley   +1 more source

The Endocrine Disrupting Compounds Bisphenol‐A and α‐Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells

Molecular Carcinogenesis, Volume 65, Issue 8, Page 907-920, August 2026.
ABSTRACT Excessive activation of the estrogen receptor (ER) drives proliferation, progression, and the formation of breast cancer stem cells (CSCs) in ER‐positive breast cancer. Estrogenic endocrine disrupting compounds (EDCs) found in plastics, water, and food are also able to bind to the ER.
Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh   +9 more
wiley   +1 more source

Changes in SERPINA1 protein expression after PCV2 infection.

, 2016
Western blotting was used to measure SERPINA1 protein expression in each group of lung tissue samples. The SERPINA1 level in LW-i was significantly higher than that in YL-i. GAPDH expression was used as the positive control. * P < 0.05.
Li Kang (494757), Pengfei Wang (123133), Liyuan Wang (795570), Shijin Jiang (3172107), Gen Liu (527432), Ping Zhang (86495), Yunliang Jiang (494758), Yi Sun (118759), Yanping Li (90163), Hao Liu (12832)   +9 more
core   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

In vivo expression of SERPINA2 and SERPINA1.

, 2013
Leukocytes were collected from blood of an individual with a V2Null genotype for SERPINA2 and a M1M2 genotype for SERPINA1. SERPINA2 was stained with K12 and Alexa Fluor 488 (green) antibodies.
Manuella Martins (426139), Patrícia Castro (5655418), Susana Seixas (180987), Joana Simões-Correia (176247), Ramiro Morales-Hojas (121624), Zélia Ferreira (5655415), Diana Isabel Silva (426140), Joana Figueiredo (176254), Patrícia Isabel Marques (426138)   +8 more
core   +1 more source

Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection

PLoS ONE, 2023
Alpha-1 antitrypsin deficiency (AATD), a relatively common autosomal recessive genetic disorder, is underdiagnosed in symptomatic individuals. We sought to compare the risk of liver transplantation associated with hepatitis C infection with AATD ...
Bryce A. Schuler, Lisa Bastarache, Janey Wang, Jing He, Sara L. Van Driest, Joshua C. Denny   +5 more
doaj  

Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome

, 2021
Background: Diagnostic biomarkers for detecting chronic obstructive pulmonary disease (COPD) in acute coronary syndrome (ACS) patients are not available.
Campo G. C., Selvatici R., Martini F., Rotondo J. C., Aquila G., Oton-Gonzalez L., Tognon M., Rizzo P., De Mattei M., Pavasini R.   +9 more
core   +1 more source