Results 101 to 110 of about 8,184 (185)

Genetic drivers of liver cirrhosis: The role of SERPINA1 and PNPLA3 variants in disease onset and progression.

PLoS ONE
SERPINA1 Z and PNPLA3 G alleles are the most potent genetic risk modifiers in chronic liver disease (CLD) progression. We aimed to test the impact of concomitant carriage of these variants on the progression of CLDs of various aetiology.
Mikolas Holinka, Sona Frankova, Svetlana Adamcova Selcanova, Lubomir Skladany, Ondrej Fabian, Martin Kveton, Dusan Merta, Vera Adamkova, Jaroslav A Hubacek, Veronika Pitova, Sarka Vesela, Tomas Hucl, Milan Jirsa, Jan Sperl   +13 more
doaj   +1 more source

SERPINA1 Gene [PDF]

, 2020
openaire   +1 more source

SERPINA1 and Alpha-1 Antitrypsin: A Review of Molecular Structure, Clinical Variants and Computational Study of Diseases Involving the Protein

BioMed Target Journal
The SERPINA1 gene, located at 14q31-32.3, is responsible for producing Alpha-1 Antitrypsin (AAT), which acts as a serine protease inhibitor to protect tissues from any proteolysis-induced damage.
Afifa Javed, Ayesha Sana Soomro, Shaheer Ali Mughal, Sameer Shahzad, Arleen Yousuf, Imrana Khushk, Abdul Sattar Qureshi   +6 more
doaj   +1 more source

Fusion transcripts landscape in hepatocellular carcinoma and potential impact on the expression of fusion partners

RNA Biology
Fusion transcripts (FTs) are RNA molecules, also known as chimeric transcripts, formed through chromosomal rearrangements or transcriptional processes, contributing to tumorigenesis.
Yasemin Öztemur Islakoğlu, Peyda Korhan, Leman Binokay, Barış Keleş, Ezgi Bağırsakçı, Meryem Uludağ Taşçıoğlu, Emine Şamdancı, Gökhan Karakülah, Neşe Atabey   +8 more
doaj   +1 more source

Regulation of SERPINA1 mRNA Expression by Environmental Conditions in Hepatocyte Cells [PDF]

The SERPINA1 gene encodes the critical protease inhibitor α-1-antitrypsin (A1AT). A1AT represses neutrophil elastase activity to protect lung tissue from inflammatory damage.
Jiamutai, FNU
core   +1 more source

Serum α1-AT Levels and SERPINA1 Molecular Analysis in Breast Cancer: An Experimental and Computational Study

Diseases
Background/Objectives: Breast cancer (BC) is a heterogeneous disease with multifactorial origins, including environmental, genetic, and immunological factors.
Guadalupe Ávalos-Navarro, Luis A. Bautista-Herrera, Asbiel Felipe Garibaldi-Ríos, Ramiro Ramírez-Patiño, Marisol Gutiérrez-García, Perla Briseño-Álvarez, Luis Felipe Jave-Suárez, Emmanuel Reyes-Uribe, Martha Patricia Gallegos-Arreola   +8 more
doaj   +1 more source

α1-Antitrypsin (SERPINA1; AAT; A1AT) [PDF]

Science-Business eXchange, 2010
openaire   +2 more sources

Serpina1e mediates the exercise-induced enhancement of hippocampal memory

Abstract The exercise-induced enhancement of learning and memory is thought to be regulated by body‒brain interactions via secretory proteins in the blood plasma 1,2 . Given the prominent role that skeletal muscle plays during exercise, the beneficial effects of exercise on ...
Hyungju Park, Hyunyoung Kim, Sanghee Shin, Jeongho Han, Jong-Seo Kim   +4 more
openaire   +1 more source

Serpin peptidase inhibitor, clade A (SERPINA1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

SERPINA1 activation by RUNX1 drives microglial M2 polarization and reduces neuronal injury in a Parkinson\u2019s disease mouse model

Microglial polarization plays a crucial role in Parkinson\u2019s disease (PD). This study explores how serpin family A member 1 (SERPINA1) suppresses neuroinflammation and alleviates neuronal damage in PD. Adeno-associated viruses were injected into mice
Cai, Xiaoyu, Zhang, Keling, Li, Ting, Ding, Shu, Yuan, Tangkun   +4 more
core   +1 more source