Results 91 to 100 of about 8,184 (185)

Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization

, 2006
Here, we report that cytokine-induced (granulocyte colony-stimulating factor and IL-8) hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) mobilization is completely inhibited after low-dose (0.5 Gy) total-body irradiation (TBI ...
Roel Willemze, Willemze, R, Ivan J. D. Lindley, van Pel, M, Henny Hagoort, Hagoort, H., Peter M. H. Heegaard, Willem E. Fibbe, Heegaard, PMH, Lindley, IJD, Ronald van Os, Gerjo A. Velders, Lindley, I.J.D., Velders, GA, Hagoort, H, Willemze, R., van Os, R, van Pel, M., Melissa van Pel, Fibbe, W.E., Velders, G.A., Heegaard, Peter M. H., Fibbe, WE, van Os, R; id_orcid, van Os, R.   +24 more
core   +1 more source

Tissue expression and alternative polyadenylation of the SERPINA1 mRNA.

, 2021
A) Tissue expression in Transcripts per Million (TPM) on a log scale for SERPINA1 mRNA for 17382 samples sequenced by the GTEx RNA-seq consortia [10,11,62].
Peter Castaldi (2993694), John Platig (3115692), Auyon J. Ghosh (8798318), Alain Laederach (243452), Victor E. Ortega (7782260), Lela Lackey (815515), Phil Grayeski (11714958), Abigail Hatfield (11773102), Aaztli Coria (11714955), Michael H. Cho (6856079), Zhonghui Xu (659900), Craig P. Hersh (8543712), Brian D. Hobbs (5118383), Vijay Shankar (3411281), Silvia B. V. Ramos (9013763), Edwin K. Silverman (6856082)   +15 more
core   +1 more source

Characterization of a novel SERPINA1 variant carrying two missense mutations: molecular mechanisms and functional impact

Orphanet Journal of Rare Diseases
Alpha 1-Antitrypsin Deficiency (AATD) is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes the Alpha 1-Antitrypsin (AAT) protein.
Celine Leon, Marie-Françoise Odou, Bertrand Roquelaure, Louis Lebreton, Mathias Ruiz, Carolin Victoria Schneider, Celine Renoux, Aurélie Evrard, Malika Balduyck, Magali Dechomet, Christine Lombard, Mathilde Butori-Pepino, Kai Markus Schneider, Victor Marin, Sylvaine di-Tomasso, Cyril Dourthe, Jean-William Dupuy, Anne-Aurélie Raymond, Sophie Collardeau-Frachon, Aurélie Haffner, Radia Fritih, Emmanuelle Goubert, Vanna Geromel, Philippe Joly, Alexandre Fabre, Marion Bouchecareilh   +25 more
doaj   +1 more source

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey   +5 more
doaj   +1 more source

Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene

PLOS ONE, 2017
Human SERPINA1 gene is located on chromosome 14q31-32.3 and is organized into three (IA, IB, and IC) non-coding and four (II, III, IV, V) coding exons. This gene produces α1-antitrypsin (A1AT), a prototypical member of the serpin superfamily of proteins.
Nerea Matamala, Nupur Aggarwal, Paolo Iadarola, Marco Fumagalli, Gema Gomez-Mariano, Beatriz Lara, Maria Teresa Martinez, Isabel Cuesta, Jan Stolk, Sabina Janciauskiene, Beatriz Martinez-Delgado   +10 more
openaire   +8 more sources

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization [PDF]

, 2005
Mobilization of hematopoietic progenitor cells into the blood involves a massive release of neutrophil serine proteases in the bone marrow. We hypothesize that the activity of these neutrophil serine proteases is regulated by the expression of naturally ...
Horvath, A, Levesque, JP, Coughlin, P, Jean Hendy, Hendy, J, Paul Coughlin, Anita Horvath, Ingrid G. Winkler, Jean-Pierre Lévesque, Winkler, IG   +9 more
core   +1 more source

Functional heterogeneity and clinical application of SERPINA1 in tumors

Zhongguo linchuang yanjiu
Serine protease inhibitor A1（SERPINA1），also known as α1-antitrypsin，is a vital member of the serine protease inhibitor superfamily. It mainly participates in protease - antiprotease balance，inflammatory response，tissue repair and immune regulation.Recent
BAI Chenxi，KUAI Xingwang，ZHANG Ke，CHEN Ken，JI Juling
doaj   +1 more source

Accurate Indentification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular AssayTake-home Points

CHEST Pulmonary
Background: α1-Antitrypsin deficiency (AATD) is a common, underdiagnosed disease caused by mutations in the polymorphic SERPINA1 gene. AATD often causes COPD, other respiratory ailments, and severe liver disease.
Emily K. DeCurtis, BSc, Sharon K. Kuss-Duerkop, PhD, Iara M.P. Machado, PhD, Zoe P. Stewart, BSc, Matt Jackson, MS, Ellie Hasenohr, BSc, Jessica L. Crumby, BSc, Steve D. Groshong, MD, PhD, Claire M. Coeshott, PhD, Ronald J. Harbeck, PhD, James P. Woodrow, MD, Robert A. Sandhaus, MD, PhD, Yongbao Wang, PhD   +12 more
doaj   +1 more source

Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data

, 2016
Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or ...
Oeckl, Patrick, Ludolph, Albert C., Haußmann, Ute, Pinkhardt, Elmar, Herukka, Sanna-Kaisa, Otto, Markus, Halbgebauer, Steffen, Nagl, Magdalena, Klafki, Hans, Steinacker, Petra, Kassubek, Jan, Wiltfang, Jens, Soininen, Hilkka   +12 more
core   +1 more source

Connecting genetic variation, gene expression, metabolites, and atherosclerosis for SERPINA1 and AQP9.

, 2012
(a) Boxplots show SNPs associated with metabolic networks are also cis eQTLs for SERPINA1 (human blood and liver) and AQP9 (human liver). Boxplots consist of median log2-normalised expression for each genotype with first and third quartiles designated by
Markku J. Savolainen (144263), Mika Ala-Korpela (74279), Markus Perola (62544), Michael Inouye (103694), Marja-Riitta Taskinen (68894), Aarno Palotie (41342), Paul I. W. de Bakker (61332), Niku Oksala (144255), Jorma Viikari (49741), Antti J. Kangas (144259), Terho Lehtimäki (49739), Marjo-Riitta Järvelin (2141947), Johannes Kettunen (120333), Pasi Soininen (74273), Olli Raitakari (144269), Mika Kähönen (131499), Samuli Ripatti (144251), Veikko Salomaa (62543), Leo-Pekka Lyytikäinen (144253), Pirkka-Pekka Laurila (144257)   +19 more
core   +1 more source