Results 91 to 100 of about 10,966 (204)

The Alpha‐1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 10, Page 1380-1389, May 2026.
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Tina Jasmin Haunold, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Nina Dominik, Michael Schwarz, Georg Kramer, Christian Sebesta, Paul Thöne, Matthias Pinter, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer   +18 more
wiley   +1 more source

SERPINA1 PiZ and PiS Heterozygotes and Lung Function Decline in the SAPALDIA Cohort

PLoS ONE, 2012
Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial. There is indication from experimental studies that pro-inflammatory agents like cigarette smoke can interact with these ...
Thun, G. A., Ferrarotti, I., Imboden, M., Rochat, T., Gerbase, M., Kronenberg, F., Bridevaux, P. O., Zemp, E., Zorzetto, M., Ottaviani, S., Russi, E. W., Luisetti, M., Probst-Hensch, N. M.   +12 more
openaire   +7 more sources

Noninvasive Tests for Predicting Decompensation in Compensated Advanced Chronic Liver Disease: A Comprehensive Review

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Strong non‐invasive tests (NITs) are needed to predict decompensation in patients with compensated advanced chronic liver disease (cACLD) and improve personalized patient care. We conducted a comprehensive review of the studies evaluating the effectiveness of NITs in predicting decompensation or liver‐related death in patients with cACLD.
Audrey Payancé, Pierre‐Emmanuel Rautou, Jérôme Boursier, Laurent Castera, Dominique Valla, Laure Elkrief   +5 more
wiley   +1 more source

Prevalence of SERPINA1 mutations in a bronchiectasis cohort: implications of extended screening for alpha-1 antitrypsin deficiency [PDF]

Jornal Brasileiro de Pneumologia
Objective: To evaluate the prevalence of alpha-1 antitrypsin (AAT) variants through SERPINA1 genotyping in patients with non-cystic fibrosis bronchiectasis, and assess their clinical, functional and radiological characteristics.
Caroline Souza Sokoloski, Mariane Gonçalves Martynychen Canan, Cleverson Alex Leitão, Karin Mueller Storrer   +3 more
doaj   +1 more source

Biomarkers for diagnosis of pre-eclampsia and endometriosis [PDF]

, 2018
Gynecological disorders are leading public health problems in developing countries with substantial impact on women's quality of life. Significant proportion of maternal mortality and reproductive morbidity is attributed to misdiagnosis ...
Ali, Amjad, Idrees, Muhammad, Nabi, Ghulam, Rafique, Shazia, Wahid, Braira, Waqar, Muhammad, Wasim, Muhammad   +6 more
core   +1 more source

Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression

Nature Communications
Lipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, we show that serine protease inhibitor A1 (SerpinA1) expression in the liver is increased during recovery from ...
Shota Okagawa, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata, Tatsuya Kondo, Naoki Takeda, Kimi Araki, Bruna Brasil Brandao, Wei-Jun Qian, Yu-Hua Tseng, Rohit N. Kulkarni, Naoto Kubota, C. Ronald Kahn, Eiichi Araki   +14 more
doaj   +1 more source

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema [PDF]

, 2014
Background: In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an
Dzyubachyk, O.M. (Oleh), Essers, J. (Jeroen), Hawinkels, L.J.A.C. (Lukas ), Heijningen, P.M. (Paula ) van, Hendriks, R.W. (Rudi), Kanaar, R. (Roland), Kleinjan, A. (Alex), Luijtgaarden, K.M. (Koen) van de, Meijering, H.W. (Erik), Munck, A. (Anne) de, Nimwegen, M. (Menno) van, Pluijm, I. (Ingrid) van der, Ramnath, N.W.M. (Natasja ), Ridwan, R.Y. (Ruziedi Y.), Rottier, R.J. (Robbert), Rouwet, E.V. (Ellen), Spek, P.J. (Peter) van der, Swagemakers, S.M.A. (Sigrid), Thiel, B.S. (Bibi) van, Vermeij, M. (Marcel), Vliet, N. (Nicole) van, Yanagisawa, J.   +21 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

SERPINA1 and HSD17B13 Gene Variants in Patients with Liver Fibrosis and Cirrhosis

Journal of Gastrointestinal and Liver Diseases, 2019
Background & Aims: Two single nucleotide polymorphisms (SNPs) in SERPINA1 (Pi*Z rs28929474 and Pi*Srs17580) are risk factors for developing liver cirrhosis. A recent study identified a common SNP in HSD17B13(rs72613567) that conferred protection from chronic liver disease.
Viktorija, Basyte-Bacevice, Jurgita, Skieceviciene, Irena, Valantiene, Jolanta, Sumskiene, Vitalija, Petrenkiene, Jurate, Kondrackiene, Dalius, Petrauskas, Frank, Lammert, Juozas, Kupcinskas   +8 more
openaire   +3 more sources

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae

Advanced Science, Volume 13, Issue 24, 27 April 2026.
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia, Yunna Zheng, Nan Yang, Jing Chen, Xi Wu, Ximing Zheng, Danrui Cui, Ruijin Wang, Xunli Lu, Dongli Wang, You‐liang Peng, Qian Chen   +11 more
wiley   +1 more source