MedComm, Volume 7, Issue 4, April 2026.Organoid technology has attracted significant attention in cancer research. By incorporating tumor organoids with elements of the tumor microenvironment in coculture systems, researchers have gained powerful new tools to unravel the complex interplay that influences tumor progression and therapeutic outcomes.
Jiajun Yang +9 more
wiley +1 more source
Dynamic Expression Pattern of SERPINA1 Gene from Duck (Anas platyrhynchos)
BioMed Research International, 2019 SERPINA1 is a member of serine protease inhibitors and is increasingly considered to be a regulator of innate immunity in human and animals. However, the expression and function of SERPINA1 gene in immune defense against viral infection remain unknown in ducks.
Tiantian Gu +8 more
openaire +2 more sources
miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency. [PDF]
, 2014 RATIONALE: Retention of abnormal α1-antitrypsin (AAT) activates the unfolded protein response in AAT-deficient monocytes. The regulatory role of microRNAs (miRNAs) in unfolded protein responses and chronic obstructive pulmonary disease pathogenesis has ...
Buckley, Patrick G +6 more
core +1 more source
Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]
, 2008 TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III +5 more
core +1 more source
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study. [PDF]
, 2018 BACKGROUND:Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study ...
Dubin, Ruth F +5 more
core +2 more sources
Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexedmicroarray biomarker validation [PDF]
, 2017 We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals.
Acera, Arantxa +11 more
core +3 more sources
Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids [PDF]
, 2011 The aim of this study was to determine the effects of supplementing unprotected dietary unsaturated fatty acids (UFAs) from different plant oils on gene expression in the mammary gland of grazing dairy cows.
Baal, J., van +4 more
core +2 more sources
PLoS Genetics, 2012 Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles.
Michael Inouye +19 more
doaj +1 more source
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects [PDF]
, 2017 The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained by recognized genetic risk factors identified as achieving genome-wide significance.
Agusti, A +31 more
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Дефицит альфа-1-антитрипсина: генетические основы, эпидемиология, значение в развитии бронхо-легочной патологии [PDF]
, 2015 альфа-1-антитрипсинбронхолегочная дисплазияКРОВИ СЫВОРОТКАмутациягенная ...
Даниленко, Н. Г. +5 more
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