Results 21 to 30 of about 30,547,503 (170)

The impact of diagnostic delay on survival in alpha-1-antitrypsin deficiency: results from the Austrian Alpha-1 Lung Registry

Respiratory Research, 2023
Background Alpha-1-antitrypsin (AAT) deficiency (AATD) is a genetic disorder that can manifest as lung disease. A delay between onset of symptoms and diagnosis of AATD is common and associated with worse clinical status and more advanced disease stage ...
Tobias Meischl, Karin Schmid-Scherzer, Florian Vafai-Tabrizi, Gert Wurzinger, Eva Traunmüller-Wurm, Kristina Kutics, Markus Rauter, Fikreta Grabcanovic-Musija, Simona Müller, Norbert Kaufmann, Judith Löffler-Ragg, Arschang Valipour, Georg-Christian Funk   +12 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. [PDF]

PLoS ONE, 2014
The human serine protease high temperature requirement A1 (HTRA1) is highly expressed in the placental tissue, especially in the last trimester of gestation. This suggests that HTRA1 is involved in placental formation and function.
Violette Frochaux, Diana Hildebrand, Anja Talke, Michael W Linscheid, Hartmut Schlüter   +4 more
doaj   +1 more source

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD

Multidisciplinary Respiratory Medicine, 2017
Background Alpha-1-antitrypsin deficiency (AATD) is an under-diagnosed condition in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to screen for AATD in Kazakh patients with COPD using dried blood spot specimens ...
Ardak Zhumagaliyeva, Stefania Ottaviani, Timm Greulich, Marina Gorrini, Claus Vogelmeier, Ludmila Karazhanova, Gulmira Nurgazina, Annalisa DeSilvestri, Victor Kotke, Valentina Barzon, Michele Zorzetto, Angelo Corsico, Ilaria Ferrarotti   +12 more
doaj   +1 more source

Three new Alpha1-Antitrypsin deficiency variants help to define a C-Terminal region regulating conformational change and polymerization [PDF]

, 2012
Alpha1-antitrypsin (AAT) deficiency is a hereditary disorder associated with reduced AAT plasma levels, predisposing adults to pulmonary emphysema.
Fra Anna M., Fra, Anna M, Anna M. Fra (157302), Scabini, Roberta, Federica Benini, Ferrarotti, Ilaria, L. Corda, Corda, Luciano, Scabini R, E. Miranda, LUISETTI, MAURIZIO, Miranda Elena, Benini, Federica, Corda, L., Benini, F., Medicina D, Luciano Corda, Maurizio Luisetti (142908), Luisa Schiaffonati, I. Ferrarotti, Anna M. Fra, Ilaria Ferrarotti (142893), Luisetti M, Gooptu Bibek, Miranda, E., SCHIAFFONATI, Luisa, Gooptu, Bibekbrata, Anna M Fra, Medicina, Daniela, Elena Miranda, Schiaffonati Luisa, Ferrarotti, I., Medicina, D., R. Ronzoni, Luisetti Maurizio, Daniela Medicina, R. Scabini, L. Schiaffonati, Roberta Scabini (157306), Ferrarotti Ilaria, Ronzoni, R., B. Gooptu, Ferrarotti I, Bibek Gooptu (157303), Luciano Corda (157317), F. Benini, Scabini Roberta, Gasset, M., A. M. Fra, MIRANDA BANOS, MARIA ELENA, Fra, A.M., Ilaria Ferrarotti, Medicina Daniela, FRA, Annamaria, RONZONI, Riccardo, Gooptu B, Daniela Medicina (157321), Ronzoni Riccardo, Benini Federica, Miranda, Elena, D. Medicina, Corda Luciano, Maurizio Luisetti, Benini F, Scabini, R., Corda L, Roberta Scabini, Riccardo Ronzoni (157309), Luisa Schiaffonati (157328), Federica Benini (157312), Riccardo Ronzoni, Gooptu, Bibek, Luisetti, M., Schiaffonati, L., Elena Miranda (21508), Bibek Gooptu, Miranda E   +76 more
core   +2 more sources

Alpha-1 antitrypsin deficiency gut microbiome

, 2020
This dataset contains 16S rRNA Illumina MiSeq sequenced samples used in our gut microbiome study in individuals with alpha-1 antitrypsin deficiency (AATD) and controls (non-AATD)
Kirst, ME (University of Florida)
core   +1 more source

Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels [PDF]

, 2013
Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood.
Marjo-Riitta Jarvelin, Kronenberg, F, Ma'en Obeidat, M. Dahl, Gian Andri Thun (449467), Caroline Hayward (149856), Ferrarotti, Ilaria, I. J. Deary (7620122), Ma'en Obeidat (110232), J. F. Wilson, Gyllensten, U, B. G. Nordestgaard (7605362), Tobin, MD, Thierry Rochat, Igor Rudan (150101), Y. Bossé (7628753), Alexander Teumer (112757), Ferrarotti, I, Børge G. Nordestgaard (89871), H. Schulz (3516554), Andrew J. Sandford (301863), M. Imboden (3809185), L. M. Lopez (7628747), C. Hayward (7609304), J. Hui (6291092), Obeidat, Ma'en, Huffman, JE, M. Jarvelin, M. D. Tobin, Strachan, David P, O. Polasek, Bossé, Y, Schulz, H, M. Zorzetto (7628732), Huffman, Jennifer E., Hui, J., A. Kumar (664258), A. J. Sandford (7628759), Ian J. Deary (107724), Haun, M., Reischl, E., Hayward, C., Victoria E. Jackson (449468), Alexessander Couto Alves, A. Teumer (7609454), Thun, Gian Andri, J. S. Ried, Nordestgaard, Borge G, Sandford, Andrew J., Fallgaard Nielsen, S., E. W. Russi, Haun, M, S. Enroth, K. Hao (7628756), M. Obeidat, T. Rochat, Probst-Hensch, Nicole M, M. Obeidat (7628729), J. F. Wilson (7605311), I. Curjuric (3809209), E. Albrecht, Timens, Wim, Deary, Ian J, E. Reischl, Kronenberg, Florian, Timens, W., Enroth, S., Ozren Polasek, David P Strachan, Imboden, M., Reischl, E, Couto Alves, A., S. Fallgaard Nielsen (7628780), Nordestgaard, Børge G., Ashish Kumar (152984), Holger Schulz (13022), Haun, Margot, Jarvelin, Marjo-Riitta, Andrew J Sandford, Beate Koch (110151), D. P. Strachan (3809152), M. Dahl (7628777), Janina S Ried, S. F. Nielsen, Koch, B., T. Rochat (7628768), Ian P. Hall (110307), Lopez, Lorna M., Kumar, A, Zorzetto, M., Morten Dahl (250510), Curjuric, I., K. Hao, Enroth, Stefan,, Curjuric, Ivan, Luisetti, M, James, A.L., B. Koch (3565709), Jennifer E Huffman, Ke Hao (50181), Rochat, T, N. M. Probst Hensch, Gyllensten, Ulf,, I. Rudan, Strachan, David P., Jarvelin, M.R., Enroth, Stefan, Jennifer E. Huffman (220403), Florian Kronenberg (87557), Maurizio Luisetti (142908), Nielsen, Sune Fallgaard, Michele Zorzetto (142902), Alan L. James (174634), Wilson, J.F., Jackson, VE, M. Luisetti (7628783), Obeidat, M., Couto Alves, A, James, Alan L, Lorna M Lopez, Stefan Enroth (189126), Florian Kronenberg, Deary, IJ, Dahl, Morten, Ashish Kumar, Bossé, Y., Erich W. Russi (142906), Lopez, L.M., Timens, W, Alan L James, Imboden, Medea, Ried, Janina S, Gyllensten, U., I. Curjuric, Schulz, Holger, Wim Timens (41871), Ried, J.S., Enroth, S, Luisetti, Maurizio, I. Rudan (7609409), A. J. Sandford, James F Wilson, Ivan Curjuric (110179), Wilson, James F; id_orcid, J. S. Ried (7628744), Huffman, Jennifer E, E. W. Russi (7628771), Morten Dahl, Probst-Hensch, NM, G. A. Thun (7628723), Medea Imboden (110145), Y. Bossé, Sune Fallgaard Nielsen (449470), Teumer, Alexander, Tobin, M.D., Gian Andri Thun, Kronenberg, F., Caroline Hayward, C. Hayward, Eva Albrecht (174584), Børge G Nordestgaard, Albrecht, E., I. P. Hall, Fallgaard Nielsen, Sune, Luisetti, M., U. Gyllensten, Bosse, Yohan, Deary, I.J., L. M. Lopez, Eva Reischl (449469), Russi, Erich W., E. Reischl (7628762), F. Kronenberg, Ulf Gyllensten, Margot Haun (102627), Strachan, D.P., Probst-Hensch, Nicole M., M. Haun, Hao, Ke, I. J. Deary, Jackson, Victoria E, Erich W Russi, Hall, Ian P, Rochat, Thierry, Hall, I.P., James, AL, Wilson, James, Rudan, Igor, Nicole M. Probst-Hensch (110284), Medea Imboden, Ivan Curjuric, Huffman, J.E., Jackson, V.E., Nordestgaard, BG, Ilaria Ferrarotti (142893), W. Timens, Curjuric, I, B. G. Nordestgaard, M. R. Jarvelin (7611464), Lorna M. Lopez (107685), Fallgaard Nielsen, S, Ferrarotti, I., Victoria E Jackson, J. Hui, Wilson, James F, Hayward, Caroline, A. Couto Alves (7628738), Thun, G.A., Lopez, LM, Koch, B, Jennie Hui, M. Haun (7628735), Hao, K, Sandford, AJ, Michele Zorzetto, Gyllensten, Ulf, Ke Hao, Ian J Deary, Tobin, Martin D, D. P. Strachan, Rochat, T., Reischl, Eva, Probst-Hensch, N.M., A. L. James (7628765), Alexessander Couto Alves (131470), Jennie Hui (220409), Hao, K., Kumar, Ashish, Dahl, M., Eva Albrecht, V. E. Jackson, Sune Fallgaard Nielsen, S. Enroth (7626632), V. E. Jackson (7628741), Teumer, A., Maurizio Luisetti, O. Polasek (7609424), Martin D Tobin, Marjo-Riitta Jarvelin (110290), A. Teumer, Jackson, Victoria E., Wim Timens, Nordestgaard, Børge G, U. Gyllensten (7612145), James F. Wilson (150146), Imboden, M, A. L. James, Hui, Jennie, Teumer, A, Nordestgaard, Borge G., Zorzetto, Michele, Ian P Hall, Nicole M Probst-Hensch, Polasek, Ozren, Hui, J, Alexander Teumer, H. Schulz, Sandford, Andrew J, Polasek, O., Jarvelin, MR, N. M. Probst-Hensch (7628786), Ried, Janina S., Ried, JS, Russi, Erich W, Albrecht, E, Hall, IP, A. C. Alves, Koch, Beate, David P. Strachan (110302), Stefan Enroth, B. Koch, Margot Haun, Gibson, Greg, J. E. Huffman, Russi, E.W., G. A. Thun, Obeidat, M, Rudan, I., Schulz, H., Wilson, JF, Russi, EW, Lopez, Lorna M, A. Kumar, Alves, Alexessander Couto, Wilson, James F., Rudan, I, Holger Schulz, F. Kronenberg (7611272), Dahl, M, E. Albrecht (7612112), Ulf Gyllensten (13773), Couto Alves, Alexessander, Deary, Ian J., Beate Koch, Ozren Polasek (3965693), Kumar, A., Thun, GA, Nørdestgaard, B.G., Thierry Rochat (110261), Albrecht, Eva, J. E. Huffman (7628750), Zorzetto, M, Hayward, C, Yohan Bossé (69571), Sandford, A.J., Ilaria Ferrarotti, Hall, Ian P., M. D. Tobin (7602575), Tobin, Martin D., I. Ferrarotti (7628726), James, Alan L., Strachan, DP, Yohan Bossé, Hayward, Caroline; id_orcid, Timens, Wim; id_orcid, W. Timens (3948230), Martin D. Tobin (110311), Polasek, O, M. Zorzetto, M. Imboden, Igor Rudan, Eva Reischl, Janina S. Ried (200003), I. P. Hall (7628774)   +323 more
core   +2 more sources

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency

, 2015
Alpha-1 antitrypsin is a positive acute phase reactant whose serum level rises in response to inflammatory stress, presumably to balance pro-inflammatory processes.
Wanner, Adam, Adam Wanner
core   +1 more source

Therapeutics: Alpha-1 Antitrypsin Augmentation Therapy

, 2017
Subjects with alpha-1 antitrypsin deficiency who develop pulmonary disease are managed following general treatment guidelines, including disease management interventions.
Lascano, Jorge, Campos, Michael, Michael Campos, Jorge Lascano   +3 more
core   +1 more source

Update on and future perspectives for the diagnosis of alpha-1 antitrypsin deficiency in Brazil

Jornal Brasileiro de Pneumologia, 2021
Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder caused by a mutation in the SERPINA1 gene, which encodes the protease inhibitor alpha-1 antitrypsin (AAT). Severe AATD predisposes individuals to COPD and liver disease.
José R Jardim, Francisco Casas-Maldonado, Frederico Leon Arrabal Fernandes, Maria Vera Cruz de O Castellano, María Torres-Durán, Marc Miravitlles   +5 more
doaj   +2 more sources