Results 201 to 210 of about 2,969,581 (290)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Analogous environments across the tropics have similar levels of tree species alpha diversity. [PDF]

Natl Sci Rev
Xiao S, Adams JM, Li S, Slik F, Griffith DM, Quaresma A, Sultana A, Rozak AH, Muñoz AA, Marshall AR, Gabriel A, Dar AA, Mansor A, Narayanan A, Herault B, Joly CA, Piotto D, Harris DJ, Drake DR, Sheil D, Rocha DSB, de Oliveira EL, Nurtjahya E, van den Berg E, Webb EL, Ibrahim FH, Saiter FZ, Wittmann F, Ardila FM, Durigan G, Shukla G, Ibarra-Manríquez G, Nagamasu H, Theilade I, Zo-Bi IC, Huamantupa-Chuquimaco I, Rangel-Ch JO, Grogan J, Dar JA, Schöngart J, Herbohn J, Poulsen JR, Williams JN, Lovett J, De Alban JD, Lozada JR, Pinto JRR, Guevara-Andino JE, Cristóbal-Azkarate J, Homeier J, Böhning-Gaese K, Hakeem KR, Feeley K, Tomlinson KW, Rasingam L, Demarchi LO, Laumonier Y, Alves LF, Montenegro LT, Satdichanh M, Macía MJ, Tabarelli M, Suganuma MS, Ríos Paredes MA, Fernandez Piedade MT, Schulze M, van de Bult M, Bastian ML, Khan ML, Hussain MS, Kessler M, Lawes MJ, Munguía-Rosas MA, Parthasarathy N, Seuaturian N, Kanda NB, Jagadeesan N, Pitman N, Onrizal O, Vetaas OR, Munishi P, Chhang P, Bispo PDC, Zakaria R, Sukri RS, Muthu R, Prasad RC, V S R, Harrison RD, Veridiano RK, Steinmetz R, Chazdon RL, Tumaneng R, Gonçalves Rolim S, Garkoti SC, Báez S, Wich S, Mukul SA, Joseph S, Vieira SA, Muthuramkumar S, Sundarapandian S, Chakravarty S, Kothandaraman S, Wendt T, Metzker T, Whitfeld T, Su T, Van Andel TR, Hans V, Arroyo-Rodríguez V, Chutipong W, Laurance WF, Carrero YA, Zhou Z.   +114 more
europepmc   +1 more source

Gut microbiome composition, not alpha diversity, is associated with survival in a natural vertebrate population. [PDF]

Anim Microbiome, 2021
Worsley SF, Davies CS, Mannarelli ME, Hutchings MI, Komdeur J, Burke T, Dugdale HL, Richardson DS.   +7 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II). [PDF]

Neurosci Biobehav Rev
Maki KA, Barb JJ, Xu S, Papneja S, Alkhatib J, Butera G, Wallen GR.   +6 more
europepmc   +1 more source

Methanogen Levels Are Significantly Associated with Fecal Microbiota Composition and Alpha Diversity in Healthy Adults and Irritable Bowel Syndrome Patients. [PDF]

Microbiol Spectr, 2022
Wang T, van Dijk L, Rijnaarts I, Hermes GDA, de Roos NM, Witteman BJM, de Wit NJW, Govers C, Smidt H, Zoetendal EG.   +9 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Depuration of a solitary ascidian depletes transient bacteria without altering microbiome alpha-diversity. [PDF]

FEMS Microbiol Ecol
Hutchings B, López-Legentil S, Stefaniak LM, Nydam ML, Erwin PM.   +4 more
europepmc   +1 more source

Adherence to Gluten-Free Diet Restores Alpha Diversity in Celiac People but the Microbiome Composition Is Different to Healthy People. [PDF]

Nutrients, 2022
Palmieri O, Castellana S, Bevilacqua A, Latiano A, Latiano T, Panza A, Fontana R, Ippolito AM, Biscaglia G, Gentile A, Gioffreda D, Decina I, Tricarico M, Sinigaglia M, Corbo MR, Mazza T, Perri F, Lamacchia C.   +17 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source