Results 31 to 40 of about 265,071 (258)

Analysis of Critical Project Success Factors—Sustainable Management of the Fast-Track Construction Industry

Buildings, 2023
Fast-track construction has recently become the prevailing construction approach globally. It enables owners and developers to make rapid returns on investment through shortened construction periods.
Khalid K. Naji, Murat Gunduz, Mohamed Adalbi   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analyzing Optimal Portfolios of Eleven Assets under Different Constraints [PDF]

SHS Web of Conferences
Portfolios, which allocate investor capital to different investments, are a common risk management strategy. It aims to spread investment risk using diversification.
Li Xinyuan
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Speaking of Securitization of Financial Assets [PDF]

Ovidius University Annals: Economic Sciences Series, 2017
The history of securitization dates back to “Middle Ages”, as it has emerged into today’s refinements under various ways of obtaining liquidity to finance business growth. As today many blame securitization and low interest rates for the American crisis,
Munteanu Bogdan
doaj  

IFRS adoption, corporate governance and faithful representation of financial reporting quality in Nigeria’s development banks

Cogent Business & Management, 2022
Development banks were designed to achieve the government’s economic priorities that were not adequately addressed by the banking industry. Studies, however, show that the activities of some development banks in Nigeria have not been as impacting as ...
Ayodeji T. Ajibade, Nelson Okutu, Folorunsho Akande, Jerry D. Kwarbai, Ifayemi M. Olayinka, Ayooluwa Olotu   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Sustainable Infrastructure Investment: Financial Drivers, Policy Dynamics and Socio-Economic Challenges [PDF]

SocioEconomic Challenges
Green finance is an important tool that would help in reducing environmental degradation and promoting sustainable development as a means of reducing the burning socio-economic challenges inherent in rapidly urbanizing nations where infrastructure ...
Binaya Patnaik, Amit Hedau
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A Neural Network Architecture for Maximizing Alpha in a Market Timing Investment Strategy

IEEE Access
In finance, assuming more risk often corresponds to the expectation of higher, compensating returns. In this setting, alpha stands out as one of the most prevalent and refined measures of risk-adjusted return ever postulated, allowing for the estimation ...
Javier H. Ospina-Holguin, Ana M. Padilla-Ospina   +1 more
doaj   +1 more source