Results 61 to 70 of about 1,942,010 (310)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Analisis Pengaruh Non Performing Loan, Dana Pihak Ketiga, terhadap Pembiayaan Akad Mudharabah di Bank Syariah [PDF]

, 2017
Penelitian ini bertujuan untuk mengetahui pengaruh Non Performing Finance, dan Dana Pihak Ketiga terhadap pemberian pembiayaan mudharabah. Sampel yang digunakan adalah NPF, DPK dan Mudharabah, dari bulan januari 2012 sampai Desember 2015.
Pradesyah, R. (Riyan)
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

A Neural Network Architecture for Maximizing Alpha in a Market Timing Investment Strategy

IEEE Access
In finance, assuming more risk often corresponds to the expectation of higher, compensating returns. In this setting, alpha stands out as one of the most prevalent and refined measures of risk-adjusted return ever postulated, allowing for the estimation ...
Javier H. Ospina-Holguin, Ana M. Padilla-Ospina   +1 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

A Model for Identifying and Analyzing of Strategy Implementation Barriers [PDF]

مطالعات مدیریت راهبردی, 2016
This research designs a model for Identifying and Analyzing of Strategy Implementation Barriers in Saman Bank. At first, the theoretical principals and concepts are reviewed and then measuring indicators of each index and dimension are derived by the ...
Mohammad Ali Babayi Zekilaki, Masoumeh Hosseinzadeh Shahri, Mahin Rahimpour, Arman Ahmadizad   +3 more
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Pengaruh Kompetensi Pejabat Penatausahaan Keuangan, Sistem Pengendalian Intern Pemerintah, Pengawasan Keuangan Daerah, Sikd dan Kualitas Sdmterhadap Nilai Informasi Pelaporan Keuangan Pemerintah Daerah Kota Dumai [PDF]

, 2017
This study aimed to analyze the effect of the competence of the financial administration officials, the internal control system, the local finance supervision, regional financial information system and the quality of human resources to the value of the ...
L, A. A. (Al), Monica, T. D. (Tengku), Taufik, T. (Taufeni)   +2 more
core  

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Market Making with Alpha Signals

International Journal of Theoretical and Applied Finance, 2019
We show how a market maker employs information about the momentum in the price of the asset (i.e. alpha signal) to make decisions in their liquidity provision strategy in an order-driven electronic market.
Á. Cartea, Yixuan Wang
semanticscholar   +1 more source