Results 71 to 80 of about 1,749,908 (279)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Dynamic exponential utility indifference valuation [PDF]
Annals of Applied Probability 2005, Vol. 15, No. 3, 2113-2143, 2005 We study the dynamics of the exponential utility indifference value process C(B;\alpha) for a contingent claim B in a semimartingale model with a general continuous filtration. We prove that C(B;\alpha) is (the first component of) the unique solution of a backward stochastic differential equation with a quadratic generator and obtain BMO estimates for ...
arxiv +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Decoding Stock Market with Quant Alphas [PDF]
Journal of Asset Management 19(1) (2018) 38-48, 2017 We give an explicit algorithm and source code for extracting expected returns for stocks from expected returns for alphas. Our algorithm altogether bypasses combining alphas with weights into "alpha combos". Simply put, we have developed a new method for trading alphas which does not involve combining them. This yields substantial cost savings as alpha
arxiv
Jensen’s Alpha Estimation Models in Capital Asset Pricing Model
Journal of Asian Finance, Economics and Business, 2018 This research examined the alternatives of Jensen's alpha (α) estimation models in the Capital Asset Pricing Model, discussed by Treynor (1961), S harpe (1964), and Lintner (1965), using the robust maximum likelihood type m-estimator (MM estimator) and ...
L. Phuoc
semanticscholar +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
CDK5 interacts with MST2 and modulates the Hippo signalling pathway
FEBS Open Bio, EarlyView.By using a yeast‐two‐hybrid system, immune precipitation and a proteomics approach, we identify a novel interaction between CDK5 and MST2, which modulates the mechano‐sensitive Hippo signalling pathway in a liver tumour cell line. MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of ...
Mehak Passi +5 more
wiley +1 more source
Academic Finance, 2016 La Finance fractale est venue au secours des modèles classiques incapables d’expliquer les anomalies boursières et des modèles linéaires inadéquats pour caractériser les processus complexes.
Monia ANTAR
doaj
Universal Fluctuations of AEX index [PDF]
, 2010 We compute the analytic expression of the probability distributions F{AEX,+} and F{AEX,-} of the normalized positive and negative AEX (Netherlands) index daily returns r(t). Furthermore, we define the \alpha re-scaled AEX daily index positive returns r(t)^\alpha and negative returns (-r(t))^\alpha that we call, after normalization, the \alpha positive ...
arxiv +1 more source
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source