Results 151 to 160 of about 1,649,512 (376)

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

B. C. G. plus recombinant interferon α2b in superficial bladder cancer

Indian Journal of Urology, 2001
We have studied the efficacy of adjuvant therapy in the form of low dose B.C.G. and interferon alpha 2b. In the present study 7patients with superficial bladder car-cinoma (6 recurrent and I primary) have been treated by TURBT and intravesical ...
Gyan Prakash Singh, Usha Singh, U S Diwedi, P B Singh   +3 more
doaj  

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections [PDF]

, 1999
Hans Peter Hefti, Michael Frese, H. R. M. Landis, Claudio Di Paolo, Adriano Aguzzi, Otto Haller, Jovan Pavlovic   +6 more
openalex   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection. [PDF]

J Virol, 2018
Xu B, Pan Q, Liang C.
europepmc   +1 more source

DEVELOPMENT OF MALIGNANT LYMPHOMA OF THE LIVER FOLLOWING INTERFERON-ALPHA THERAPY FOR CHRONIC HEPATITIS C

, 1996
Yoshihiro Sugimoto, Katsuyoshi Tabuse, Kazunari Mori, Takeshi Tsuji, Masami Oka, Satoshi Asano, Takashi Ozaki, Hisaya Hirai, Yoji Tabuse   +8 more
openalex   +2 more sources

Intensive chemotherapy induction followed by interferon-alpha maintenance in patients with Philadelphia chromosome-positive chronic myelogenous leukemia [PDF]

, 1991
Hagop M. Kantarjian, Moshe Talpaz, Michael J. Keating, Elihu H. Estey, Susan O’Brien, Miloslav Beran, K. B. McCredie, J. U. Gutterman, Emil J. Freireich   +8 more
openalex   +1 more source

Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection.

Cell Host and Microbe, 2015
C. Ng, B. Sullivan, J. Teijaro, A. M. Lee, M. Welch, Stephanie Rice, K. Sheehan, R. Schreiber, M. Oldstone   +8 more
semanticscholar   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source