Results 51 to 60 of about 331,046 (340)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model

Memorias do Instituto Oswaldo Cruz, 2001
Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits ...
Marcia Maria de Souza, Raymundo Paraná, Christian Trepo, Aryon A Barbosa Jr, Irismar Oliveira, Zilton A Andrade   +5 more
doaj   +1 more source

Interferon Side Effects: When Somatization Betrays You - A Case Report [PDF]

, 2015
Neuropsychiatric symptoms are widely reported in association with both hepatitis C and IFNα treatment [1]its sequelae, and its treatment. In particular, interferon, a primary component of treatment for chronic hepatitis C, has been strongly associated ...
Domingues, V., França, M., Neves, S.
core  

Clinical-evolutional particularities of the cryoglobulinemic vasculitis in the case of a patient diagnosed with hepatitis C virus in the predialitic phase [PDF]

, 2018
Hepatitis C virus (HCV) represents a fundamental issue for public health, with long term evolution and the gradual appearance of several complications and associated pathologies.
Boldeanu, Lidia, Boldeanu, Mihail V., Caragea, Daniel C., Ciurea, Marius E., Ciurea, Tudorel, Forțofoiu, Maria, Forțofoiu, Mircea C., Popescu-Drigă, Mircea, Pădureanu, Vlad, Rogoveanu, Ion, Streba, Costin, Săndulescu, Larisa, Vere, Cristin C.   +12 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C [PDF]

, 1996
Tumor necrosis factor alpha (TNF-alpha) is a cytokine with pleiotropic properties that is induced in a variety of pathological situations including viral infections.
Civeira, M.P. (María Pilar), Garcia, N. (Nicolás), Larrea, E. (Esther), Prieto, J. (Jesús), Qian, C. (Cheng)   +4 more
core  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

Clinics, 2012
OBJECTIVE: To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity,
Mariana Postal, Nailu Angélica Sinicato, Karina Oliveira Peliçari, Roberto Marini, Lilian Tereza Lavras Costallat, Simone Appenzeller   +5 more
doaj  

IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN

Детские инфекции (Москва), 2015
The article demonstrates that the basis for pathogenesis of acute respiratory infection (ARI ) is a deficiency in a number of factors of virus protection.
V. V. Malinovskaya, V. P. Timina, L. N. Mazankova, T. A. Chebotareva   +3 more
doaj   +1 more source

Primary Lymphoma of the Gastrointestinal Tract [PDF]

, 2001
Chronic hepatitis due to hepatitis B virus (HBV) or hepatitis C virus (HCV) is still a major problem in terms of progressive liver damage, prevention and therapy in most parts of the world. Unfortunately, to date, there is still no specific and effective
Marwoto, W. (Wirasmi), Rachmat, K. B. (Kukuh), Reksodiputro, A. H. (A), Sulaiman, A. (Ali), Waspodo, A. S. (Agus)   +4 more
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