Results 191 to 200 of about 3,104,746 (304)

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release. [PDF]

Mol Pharmacol
Issa NT, Shen T, Vizurraga A, Pronin A, Henry T, Wang Q, Kwarcinski FE, Schürer S, Badiavas E, Tall GG, Slepak VZ.   +10 more
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Prolonged response to PIK3CA inhibition in an advanced hormone-positive breast cancer patient with 3 mutations in the alpha subunit of PI-3 kinase. [PDF]

Oncologist
Merose R, Leibowitz R.
europepmc   +1 more source

Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. [PDF]

Bioengineered, 2021
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C, Ke Q.   +9 more
europepmc   +1 more source

Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

Proceedings of the National Academy of Sciences of the United States of America, 1990
M. Strathmann, Thomas M. Wilkie, M. Simon   +2 more
semanticscholar   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

The Na⁺-K⁺-ATPase alpha subunit is an entry receptor for white spot syndrome virus. [PDF]

mBio
Zhou J, Zhang H, Wu G, Zhang Y, Aweya JJ, Tayyab M, Zhu J, Zhang Y, Yao D.   +8 more
europepmc   +1 more source

Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia. [PDF]

Hum Vaccin Immunother, 2020
Aldoss I, Clark M, Song JY, Pullarkat V.
europepmc   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Altering Active-Site Loop Dynamics Enhances Standalone Activity of the Tryptophan Synthase Alpha Subunit. [PDF]

ACS Catal
Duran C, Kinateder T, Hiefinger C, Sterner R, Osuna S.   +4 more
europepmc   +1 more source