Results 71 to 80 of about 1,319,935 (211)

The prevalence of alpha-thalassemia amongst Tai and Mon-Khmer ethnic groups residing in northern Thailand: A population-based study

Hematology, 2016
Background: Northern Thailand is one of the highest α-thalassemia incidence areas where 30–40% of inhabitants have been reported to carry aberrant α-globin genes.
P. Lithanatudom, Pornnapa Khampan, Duncan R. Smith, S. Svasti, S. Fucharoen, D. Kangwanpong, Jatupol Kampuansai   +6 more
semanticscholar   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source

Alpha- Thalassemia: An Overview

Scholars Journal of Applied Medical Sciences, 2023
Alpha-Thalassemia is the commonest hereditary monogenic disease worldwide. α-thalassemia is caused by α-globin gene losses and categorized into α-thalassemia 1 and α-thalassemia 2 depending on how many α-globin genes are functioning. Α thalassemia 1 is defined by inactivation of both α-globin genes on a chromosome, while in α-thalassemia 2, one gene is
openaire   +1 more source

Alpha and beta-Thalassemia mutations in Hubei area of China

BMC Medical Genetics, 2020
BackgroundThalassemia is a group of inherited hemoglobic disorders resulting from defectsin the synthesis of one or more of the hemoglobin chains, which is one of the most prevalent inherited disorders in southern China.
Yao-wu Zhu, Na Shen, Xiong Wang, Juan Xiao, Yanjun Lu   +4 more
semanticscholar   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major

مجلة كلية الطب
Background: Beta-thalassemia major is a prevalent global condition characterized by a rapid breakdown of red blood cells. Regular blood transfusions can give rise to problems such as cardiovascular disease, diabetes, osteoporosis, and renal disorders ...
Ahmed J. Kadhim, Hedef D. El-Yaseen, Ali M. Jawad   +2 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Determination of the Need for Prenatal Diagnosis in Carriers of Alpha Thalassemia

مجله دانشکده پزشکی اصفهان, 2013
Background: In recent years, both alpha and beta thalassemia have been screened in couples before marriage. The severe form of alpha thalassemia, i.e. hydrops fetalis, is found in fetuses and causes fetal death.
Mitra Ramezani, Yadollah Ramezani, Davood Amirian, Mansoor Salehi   +3 more
doaj  

The Effect of Xmn -1 Polymorphism and Coinheritance of Alpha Mutations on Age at First Blood Transfusion in Iranian Patients with Homozygote IVS 1-5 Mutation

International Journal of Hematology-Oncology and Stem Cell Research, 2022
Background: Thalassemia syndromes are the most prevalent hereditary hemoglobinopathies in the world. Iran is located on the thalassemia belt.  In this study, the effect of Xmn -1 polymorphism and coinheritance of alpha mutations on age at first ...
Mozhgan Hashemieh, Zahraalsadat Saadatmandi, Azita Azarkeivan, Hossein Najmabadi   +3 more
doaj  

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source