Results 131 to 140 of about 58,433 (316)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Canterbury Alphabet: P

, 2020
Original: brush, ink and gouache on purple prepared paper, 7” x 7” Created in part during a residency at Canterbury Shaker Village in 2020 Canterbury Alphabet series: Canterbury Alphabet: A Canterbury Alphabet: B Canterbury Alphabet: C Canterbury ...
Burt, Stephen
core  

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Canterbury Alphabet: Y

, 2020
Original: brush, ink and gouache on purple prepared paper, 7” x 7” Created in part during a residency at Canterbury Shaker Village in 2020 Canterbury Alphabet series: Canterbury Alphabet: A Canterbury Alphabet: B Canterbury Alphabet: C Canterbury ...
Burt, Stephen
core  

Ideology and Alphabets in the former USSR. [PDF]

, 2006
In 2002 the Russian parliament passed a law requiring all official languages within the Russian Federation to use the Cyrillic alphabet. The legislation caused great controversy and anger in some quarters, especially in Tatarstan, the Russian republic ...
Sebba, Mark
core  

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

RUSSIAN IN MULTICULTURAL EDUCATIONAL PARADIGM: PROBLEMS OF TEACHING PROCESS ORGANIZATION AND TEACHING METHODS

Advanced Engineering Research, 2011
Modern methods of teaching Russian can be divided into three main areas: 1) Russian as native language, 2) Russian as non-native language, 3) Russian as foreign language. The second direction is the least developed and often misinterpreted as ‘Russian in
Irina P. Lysakova, Sergey S. Khromov
doaj  

The End of the Alphabet Poems

These poems -- intrepid, obsessive, and erotic -- tell the story of a woman's attempt to overcome despair. Claudia Rankine, whose first collection was the prize-winning Nothing in Nature is Private, creates a transfixing testimonial to a woman facing her
Rankine, Claudia.
core  

Canterbury Alphabet: Q

, 2020
Original: brush, ink and gouache on purple prepared paper, 7” x 7” Created in part during a residency at Canterbury Shaker Village in 2020 Canterbury Alphabet series: Canterbury Alphabet: A Canterbury Alphabet: B Canterbury Alphabet: C Canterbury ...
Burt, Stephen
core  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source