Results 11 to 20 of about 10,659 (171)

Bats from an area of the Colombian Caribbean reveal the circulation of Alphacoronavirus [PDF]

Curr Res Parasitol Vector Borne Dis
The evolutionary origin of coronaviruses is related to bats (order Chiroptera), and their association with pathologies in animals and humans is expected. Anthropic threats reduce bat diversity and expose humans to extraordinary transmission and spread of associated viruses, putting health and food security at risk owing to the multiple ecological roles
Martínez C, Echeverri D, Calderón A, Hurtado E, Gastelbondo B, López Y, Martínez J, López Y, Botero Y, Guzmán C, Galeano K, Bertel V, Herrera Y, Arrieta G, Araujo J, Mattar S.   +15 more
europepmc   +5 more sources

Genomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020

Viruses, 2021
Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of
Hai-Quynh Do, Van-Giap Nguyen, Chul-Un Chung, Yong-Shin Jeon, Sook Shin, Kuem-Chan Jang, Le Bich Hang Pham, Aeri Kong, Cheong-Ung Kim, Yong-Ho Park, Bong-Kyun Park, Hee-Chun Chung   +11 more
doaj   +3 more sources

Human Alphacoronavirus Universal Primers for Genome Amplification and Sequencing

Frontiers in Microbiology, 2022
Rapid and accurate sequencing covering the entire genome is essential to identify genetic variations of viral pathogens. However, due to the low viral titers in clinical samples, certain amplification steps are required for viral genome sequencing.
Sungmi Choi, Kwan Woo Kim, Keun Bon Ku, Seong-Jun Kim, Changwoo Park, Changwoo Park, Changwoo Park, Dongju Park, Dongju Park, Dongju Park, Seil Kim, Seil Kim, Seil Kim, Hana Yi, Hana Yi   +14 more
doaj   +3 more sources

A genus-specific nsp12 region impacts polymerase assembly in Alphacoronavirus and Gammacoronavirus. [PDF]

J Biol Chem
Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research across all
Hoferle PJ, Anderson TK, Kirchdoerfer RN.   +2 more
europepmc   +4 more sources

Genomic characterization of Alphacoronavirus from Mops condylurus bats in Nigeria

Virus Research, 2023
Coronaviruses (CoVs) are responsible for sporadic, epidemic and pandemic respiratory diseases worldwide. Bats have been identified as the reservoir for CoVs. To increase the number of complete coronavirus genomes in Africa and to comprehend the molecular
Uwem George, Oluwadamilola George, Judith Oguzie, Oluwadamilola Osasona, Babatunde Motayo, Joshua Kamani, Philomena Eromon, Onikepe Folarin, Anise Happi, Isaac Komolafe, Christian Happi   +10 more
doaj   +3 more sources

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells. [PDF]

PLoS Pathogens
COVID-19 pandemic caused by the SARS-CoV-2 which is well-publicized cross-species transmissibility. SARS-CoV-2 belongs to genus Betacoronavirus, several pathogenic alphacoronaviruses have shown similar patterns of emergence.
Lei Shi, Yu Zhang, Yueyue Duan, Maowen Sun, Cong Yuan, Liyan Cao, Xiangyu Kong, Wenlong Zhang, Haixue Zheng, Qi Wang   +9 more
doaj   +2 more sources

An alphacoronavirus polymerase structure reveals conserved co-factor functions [PDF]

, 2023
AbstractCoronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most of our understanding of coronavirus molecular biology comes from the betacoronaviruses like SARS-
Thomas K. Anderson, Peter J Hoferle, Kenneth W. Lee, Joshua J. Coon, Robert N. Kirchdoerfer   +4 more
openalex   +3 more sources

Detection of avian, murine, bovine, shrew, and bat coronaviruses in wild mammals from Mexico [PDF]

Virology Journal
Coronaviruses infect a wide range of animal and human hosts. Some human coronaviruses, such as SARS-CoV, MERS-CoV, and SARS-CoV-2, originated in animals, with bats often serving as ancestral hosts.
Jocelyn Medina-Gudiño, Yolanda López-Vidal, J. Adolfo Pardo-Tovar, Lauro Velázquez-Salinas, Francisco Javier Basurto-Alcántara   +4 more
doaj   +2 more sources

Molnupiravir Inhibits Replication of Multiple Alphacoronavirus suis Strains in Feline Cells

Pathogens
The cross-species spillover of coronaviruses is considered a serious public health risk. Feline coronavirus (FCoV), canine coronavirus (CCoV), and transmissible gastroenteritis virus (TGEV) are all classified under Alphacoronavirus suis and infect ...
Tomoyoshi Doki, Kazuki Shinohara, Kaito To, Tomomi Takano   +3 more
doaj   +3 more sources

Molecular diversity of Alphacoronavirus 1 in dogs and cats in Colombia [PDF]

Heliyon, 2020
Alphacoronavirus 1 (subgenus Tegacovirus, genus Alphacoronavirus, family Coronaviridae), which encompasses transmissible gastroenteritis virus (TGEV), feline coronavirus (FCoV) and canine coronavirus (CCoV), is an important pathogen that can cause severe gastroenteritis and is distributed worldwide.
Nelson Fernando Santana-Clavijo, Diana Patricia Reyes Romero, Darío Fajardo, A. Velandia Muñoz, Sueli Akemi Taniwaki, S.O. de Souza Silva, Paulo Eduardo Brandão   +6 more
openalex   +4 more sources