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Alphavirus vectors and vaccination
Reviews in Medical Virology, 2002AbstractAlphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded alphavirus genome is divided into two ORFs. The first ORF encodes the nonstructural proteins that are translated upon entry of the virus into the cytoplasm and are ...
Jonathan O, Rayner +2 more
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2000
Publisher Summary This chapter describes the mechanics, including how alphaviruses function as expression vectors and some features that make them useful. It also describes some of the ways in which alphaviruses have been used and some potential ways they can be of value. Alphaviruses are positive-strand RNA-enveloped viruses.
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Publisher Summary This chapter describes the mechanics, including how alphaviruses function as expression vectors and some features that make them useful. It also describes some of the ways in which alphaviruses have been used and some potential ways they can be of value. Alphaviruses are positive-strand RNA-enveloped viruses.
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Alphavirus Hybrid Virion Vaccines
1996Many members of the alphavirus family are important human or veterinary pathogens. These viruses are extremely similar in molecular architecture yet differ in host range and in the pathological consequences of infection. Despite marked structural conservation, the various species are inefficient in eliciting immunological cross protection. Previously(l)
A, Shafferman +10 more
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Alphavirus-Based Antigen Preparation
2020Alphavirus-based vectors present an efficient approach for antigen preparation applied for vaccine development. Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been engineered for high-level expression of antigens targeting infectious diseases and tumors.
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The Identification and Development of a Novel Oncolytic Virus: Alphavirus M1
Human Gene Therapy, 2020Oncolytic virotherapy represents an ideal therapeutic platform for cancer in which natural or engineered viruses selectively replicate in and destroy tumor cells, whereas sparing normal cells.
Jing Cai, Guangmei Yan
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Host responses to alphavirus infection
Immunological Reviews, 2008Summary: Members of the Alphavirus genus are classified into New World and Old World groups based upon their disease characteristics and primary areas of endemicity. The two groups exhibit noteworthy differences in pathogenesis during human infection, with Old World viruses primarily causing febrile and arthritogenic diseases and the New World viruses
Kate D, Ryman, William B, Klimstra
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Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8
Cell, 2023Ofer Zimmerman +24 more
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Alphavirus-Based Expression Systems
1996Alphaviruses are enveloped positive-strand RNA viruses transmitted to vertebrate hosts via mosquito vectors (reviewed in 34). In the last several years, the alphavirus RNA replication and packaging machinery have been exploited for cytoplasmic expression of heterologous RNAs and proteins in animal cells (for reviews see 3, 24, 27).
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Alphavirus Entry into Host Cells
2015Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic.
Ricardo, Vancini +2 more
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Purification and Concentration of Alphavirus
Cold Spring Harbor Protocols, 2012The alphaviruses Semliki Forest virus and Sindbis virus have been used frequently as expression vectors in vitro and in vivo. Usually, these systems consist of replication-deficient vectors that require a helper vector for packaging of recombinant particles. Replication-proficient vectors have also been engineered.
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