The Host Non-Coding RNA Response to Alphavirus Infection [PDF]
Viruses, 2023 Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
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Entry receptors — the gateway to alphavirus infection [PDF]
The Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past
Ofer Zimmerman +4 more
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Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection [PDF]
Cells, 2022 Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of acute inflammatory Guillain–Barre syndrome ...
Yosra Bedoui +6 more
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An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis [PDF]
Cell Host and Microbe, 2020 Alphaviruses are emerging, mosquito-transmitted RNA viruses with poorly understood cellular tropism and species selectivity. Mxra8 is a receptor for multiple alphaviruses including chikungunya virus (CHIKV).
Katherine Basore +2 more
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Alphavirus infection triggers antiviral RNAi immunity in mammals
Cell Reports, 2023 Summary: RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting ...
Jing Kong +7 more
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Distinct Cellular Tropism and Immune Responses to Alphavirus Infection [PDF]
Annual Review of Immunology, 2022 Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic and encephalitic alphaviruses results in distinct clinical manifestations, both virus groups induce robust innate and adaptive immune responses.
Natasha Kafai +2 more
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The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis [PDF]
Cell, 2020 Marco Colonna +2 more
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Hidden in Plain Sight: Alphavirus Persistence and Its Potential for Driving Chronic Pathogenesis [PDF]
VirusesAlphaviruses have historically been viewed as acute, self-limiting pathogens. However, growing evidence shows that viral RNA and antigens can persist in vertebrate hosts long after the resolution of acute infection, a phenomenon known as viral ...
Maria del Mar Villanueva Guzman +3 more
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The ability of alphavirus replicases to synthesize non-viral type I interferon-inducing RNAs correlates with viral RNA synthesis and has a diverse impact on virus replication and pathogenicity [PDF]
Journal of VirologyAlphaviruses have positive-strand RNA genomes that mimic cellular mRNAs, and their translation results in the synthesis of nonstructural (ns) polyprotein, the precursor of viral replicase.
Ailar Omler +3 more
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Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila [PDF]
Cell Reports, 2019 Rong Zhang +2 more
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