Results 41 to 50 of about 12,278 (197)

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry. [PDF]

PLoS Pathogens, 2013
The enveloped alphaviruses include important and emerging human pathogens such as Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-mediated endocytosis, and exit by budding from the plasma membrane.
Yaw Shin Ooi, Katie M Stiles, Catherine Y Liu, Gwen M Taylor, Margaret Kielian   +4 more
doaj   +1 more source

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]

PLoS Pathogens, 2012
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani, Michael R Wiley, Marta G Murreddu, Zach N Adelman, Kevin M Myles   +4 more
doaj   +1 more source

The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

Cell Reports, 2021
Summary: Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus E2 protein can protect against infection, the functional significance of non-neutralizing mAbs is poorly understood.
James T. Earnest, Autumn C. Holmes, Katherine Basore, Matthias Mack, Daved H. Fremont, Michael S. Diamond   +5 more
doaj   +1 more source

Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.

PLoS Neglected Tropical Diseases, 2017
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud   +9 more
doaj   +1 more source

Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall [PDF]

Journal of Virology, 2021
Abstract The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a ...
Lana Langendries, Sofie Jacobs, Rana Abdelnabi, Sam Verwimp, Suzanne Kaptein, Pieter Baatsen, Lieve Van Mellaert, Leen Delang   +7 more
openaire   +2 more sources

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +1 more source

Investigating the Role of Sphingosine Kinases During Alphavirus Infection [PDF]

, 2022
Several alphaviruses, critical human pathogens, have re-emerged in recent years. Alphaviruses are found on all continents and infect both invertebrates and vertebrates, including some aquatic animals.
Oyewole, Opeoluwa
core   +1 more source