Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture [PDF]
Nature CommunicationsAlphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril +16 more
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Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight [PDF]
Veterinary Research, 2016 Salmonid alphavirus (SAV) is an enveloped, single-stranded, positive sense RNA virus belonging to the family Togaviridae. It causes economically devastating disease in cultured salmonids. The characteristic features of SAV infection include severe histopathological changes in the heart, pancreas and skeletal muscles of diseased fish.
Herath, Tharangani +7 more
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The Role of Innate Cells During Alphavirus Chikungunya Infection
VirusesAlphavirus chikungunya (CHIKV) is an arthropod-borne alphavirus of the Togaviridae family, transmitted primarily by Aedes aegypti and Ae. albopictus mosquitoes.
Juliane Santos de França da Silva +9 more
doaj +3 more sources
Innate immune control of alphavirus infection. [PDF]
Curr Opin Virol, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Carpentier KS, Morrison TE.
europepmc +4 more sources
Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
doaj +1 more source
Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX3CR1+ Macrophages in Tissue Repair. [PDF]
mBio, 2020 Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks.
Zaid A +15 more
europepmc +3 more sources
Host-pathogen interactions during alphavirus infection [PDF]
, 2021 Arthritogenic alphavirus infection causes debilitating pain in the joints and muscles with many patients experiencing such symptoms chronically. However, there is insufficient evidence to explain the underlying causes behind symptoms of persistent ...
Lim, Elisa X
core +1 more source
Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses [PDF]
, 2022 Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern.
Liu, Xiang +5 more
core +1 more source
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression
Viruses, 2021 Baby hamster kidney-21 (BHK-21) cells are widely used to propagate and study many animal viruses using infection and transfection techniques. Among various BHK-21 cell clones, the fibroblast-like BHK-21/C-13 line and the epithelial-like BHK-21/WI-2 line ...
Peiqi Yin, Margaret Kielian
doaj +1 more source
The Regulation of Translation in Alphavirus-Infected Cells [PDF]
Viruses, 2018 Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco +2 more
openaire +4 more sources