Distinct Cellular Tropism and Immune Responses to Alphavirus Infection. [PDF]
Annu Rev Immunol, 2022 Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic and encephalitic alphaviruses results in distinct clinical manifestations, both virus groups induce robust innate and adaptive immune responses.
Kafai NM, Diamond MS, Fox JM.
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Alphavirus infection triggers antiviral RNAi immunity in mammals
Cell Reports, 2023 Summary: RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting ...
Jing Kong +7 more
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Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses. [PDF]
Viruses, 2016 Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly intensified in the last decade partly due to the re-emergence and dramatic expansion of chikungunya ...
Fros JJ, Pijlman GP.
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Innate immune control of alphavirus infection. [PDF]
Curr Opin Virol, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Carpentier KS, Morrison TE.
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The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis. [PDF]
Cell, 2020 Winkler ES +16 more
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An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. [PDF]
Cell Host Microbe, 2020 Kim AS +18 more
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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis. [PDF]
J Virol, 2018 ABSTRACT Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited. Mosquito vectors such as Aedes and Culex
Fong SW, Kini RM, Ng LFP.
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Neurological Sequelae Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2016 The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA viruses in the Togaviridae family.
Ronca SE, Dineley KT, Paessler S.
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Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. [PDF]
Cell Rep, 2019 Zhang R +10 more
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Cells, 2021 Alphaviruses are a group of arboviruses that generate chronic inflammatory rheumatisms in humans. Currently, no approved vaccines or antiviral therapies are available to prevent or treat alphavirus-induced diseases.
Anthony Dobi +3 more
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