Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures [PDF]
VirusesChikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M Lantz, Victoria K Baxter
exaly +4 more sources
A High-Throughput Antiviral Assay Based on a Sindbis Virus-GFP for the Discovery of Inhibitors of Alphavirus Replication [PDF]
VirusesThe re-emergence of alphaviruses (family Togaviridae), such as chikungunya virus, poses significant public health risks, with direct impact on quality of life and work productivity.
Gabriel Augusto Pires de Souza +9 more
doaj +2 more sources
In silico reconstruction of a salmonid alphavirus virion reveals distinctive molecular features implicated in virulence [PDF]
iScienceSummary: Salmonid alphavirus (SAV) poses a significant disease threat to aquaculture. Recently, new alphaviruses from several fish species have been discovered. However, little is known about their biology and pathogenicity.
Stéphane Biacchesi +6 more
doaj +2 more sources
Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death
Cells, 2020 Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals.
Carine Maisse
exaly +3 more sources
Alphaviruses Detected in Mosquitoes in the North-Eastern Regions of South Africa, 2014 to 2018
Viruses, 2023 The prevalence and distribution of African alphaviruses such as chikungunya have increased in recent years. Therefore, a better understanding of the local distribution of alphaviruses in vectors across the African continent is important.
Milehna M Guarido +2 more
exaly +3 more sources
Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses [PDF]
Virus ResearchAlphaviruses in the family Togaviridae include zoonotic arthropod-borne viruses, including Sindbis virus (SINV), chikungunya virus, as well as insect-specific viruses such as Eilat virus (EILV).
Chadwic De’Sean Mears +10 more
doaj +2 more sources
Journal of VirologyChikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li +5 more
exaly +3 more sources
Arthritogenic Alphaviruses: A Worldwide Emerging Threat?
Microorganisms, 2019 Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it
Laura I Levi, Marco Vignuzzi
exaly +3 more sources
Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity [PDF]
Frontiers in Public HealthArboviruses represent a global public health challenge. The lack of diagnostic protocols and the presence of asymptomatic infections complicate confirmatory diagnostics.
Andrea Valles-Morera +9 more
doaj +2 more sources
Innate immune evasion by alphaviruses
Frontiers in Immunology, 2022 Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection.
Yihan Liu +7 more
doaj +1 more source