Results 1 to 10 of about 10,044 (209)

Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents

Viruses
Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world.
Kenneth Lundstrom
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Perspectives for applying Alphaviruses in antitumor therapy

Инфекция и иммунитет, 2023
Oncolytic viral therapy is a promising approach for treating tumors. Oncolytic viruses can directly lyse tumor cells and indirectly activate antitumor immunity.
Alina S. Nazarenko, Yulia K. Biryukova, Nadezhda M Kolyasnikova, Mikhail F. Vorovich, Nikolai B. Pestov, Aidar A. Ishmukhametov   +5 more
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Alphavirus-Based Vaccines

Viruses, 2014
Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

Viruses, 2019
Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made ...
Michela Mazzon, Ana Maria Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Katy Skelton, Laura Farleigh, Joachim J. Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner, Mark Marsh   +17 more
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Venezuelan Equine Encephalitis Complex Alphavirus in Bats, French Guiana

Emerging Infectious Diseases, 2021
Although essential for control strategies, knowledge about transmission cycles is limited for Venezuelan equine encephalitis complex alphaviruses (VEEVs).
Carlo Fischer, Dominique Pontier, Ondine Filippi-Codaccioni, Jean-Batiste Pons, Ignacio Postigo-Hidalgo, Jeanne Duhayer, Sebastian Brünink, Jan Felix Drexler   +7 more
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Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

Frontiers in Cellular Neuroscience, 2014
The central nervous system (CNS) is a highly complex network comprised of long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain.
Daniela eMichlmayr, Jean K Lim
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Differential susceptibility of human microglia HMC3 cells and brain microvascular endothelial HBEC-5i cells to Mayaro and Una virus infection

Frontiers in Virology
Mayaro (MAYV) and Una (UNAV) are emerging alphaviruses circulating in the Americas. Earlier reports have revealed that MAYV infects different human cell lines, including synovial and dermal fibroblasts, chondrocytes, osteoblasts, astrocytes and pericytes,
Dalkiria Campos, Madelaine Sugasti-Salazar, Madelaine Sugasti-Salazar, Patricia Valdés-Torres, Patricia Valdés-Torres, Paola Elaine Galán-Jurado, Dalel Zegarra, Dalel Zegarra, José González-Santamaría   +8 more
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Circulation of 2 Barmah Forest Virus Lineages in Military Training Areas, Australia

Emerging Infectious Diseases, 2020
During 2017–2018, Barmah Forest virus was recovered from mosquitoes trapped in military training areas in Australia and from a soldier infected at 1 of these areas.
Wenjun Liu, Joanne R. Kizu, David R. Matley, Richard Grant, Fiona J. McCallum, Christopher G. Moller, Tracy L. Carthew, Jun Hang, Ania J. Gubala, John G. Aaskov   +9 more
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First Record of Mosquito-Borne Kyzylagach Virus in Central Europe

Viruses, 2020
RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová, Patrik Dočkal, Petra Straková, Jan Mendel, Oldřich Šebesta, Lenka Betášová, Hana Blažejová, Zdeněk Hubálek, Ivo Rudolf   +8 more
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YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
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