A High-Throughput Antiviral Assay Based on a Sindbis Virus-GFP for the Discovery of Inhibitors of Alphavirus Replication [PDF]
VirusesThe re-emergence of alphaviruses (family Togaviridae), such as chikungunya virus, poses significant public health risks, with direct impact on quality of life and work productivity.
Gabriel Augusto Pires de Souza +9 more
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In silico reconstruction of a salmonid alphavirus virion reveals distinctive molecular features implicated in virulence [PDF]
iScienceSummary: Salmonid alphavirus (SAV) poses a significant disease threat to aquaculture. Recently, new alphaviruses from several fish species have been discovered. However, little is known about their biology and pathogenicity.
Stéphane Biacchesi +6 more
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Innate immune evasion by alphaviruses
Frontiers in Immunology, 2022 Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection.
Yihan Liu +7 more
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The alphaviruses: gene expression, replication, and evolution [PDF]
Microbiological Reviews, 1994 The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
exaly +5 more sources
Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses [PDF]
Virus ResearchAlphaviruses in the family Togaviridae include zoonotic arthropod-borne viruses, including Sindbis virus (SINV), chikungunya virus, as well as insect-specific viruses such as Eilat virus (EILV).
Chadwic De’Sean Mears +10 more
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Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures [PDF]
VirusesChikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M. Lantz, Victoria K. Baxter
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Arthritogenic Alphaviruses: A Worldwide Emerging Threat?
Microorganisms, 2019 Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it
Laura I Levi, Marco Vignuzzi
exaly +3 more sources
Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity [PDF]
Frontiers in Public HealthArboviruses represent a global public health challenge. The lack of diagnostic protocols and the presence of asymptomatic infections complicate confirmatory diagnostics.
Andrea Valles-Morera +9 more
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Low capacity for molecular detection of Alphaviruses other than Chikungunya virus in 23 European laboratories, March 2022. [PDF]
PLoS ONEAlphaviruses comprise over 30 identified species spread worldwide and carry a large global health burden. With vector expansion occurring in and around Europe, it is anticipated this burden will increase.
Laura Pezzi +12 more
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Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
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