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Antiviral Strategies against Arthritogenic Alphaviruses [PDF]

Microorganisms, 2020
Alphaviruses are members of the Togaviridae family that are mainly transmitted by arthropods such as mosquitoes. In the last decades, several alphaviruses have re-emerged, causing outbreaks worldwide. One example is the re-emergence of chikungunya virus (
Rana Abdelnabi, Leen Delang
doaj   +2 more sources

Near pan-alphavirus neutralization by an antibody-nanobody bispecific [PDF]

mAbs
Alphaviruses represent a global concern, with some such as chikungunya virus currently infecting thousands in China and others such as Venezuelan equine encephalitis virus inducing neurological symptoms in 4–14% of infected individuals. A single antibody
Sergei Pletnev, Christina L. Gardner, Matthew S. Sutton, Baoshan Zhang, Victoria Callahan, Courtney Green, Nicholas C. Morano, Tatsiana Bylund, Megan M. Dunagan, Yaroslav Tsybovsky, Ellen R. Goldman, Lawrence Shapiro, Crystal W. Burke, Julie M. Fox, Mario Roederer, Peter D. Kwong, Tongqing Zhou   +16 more
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Innate immune evasion by alphaviruses

Frontiers in Immunology, 2022
Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection.
Yihan Liu, Yihan Liu, Yihan Liu, Yupei Yuan, Yupei Yuan, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
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A High-Throughput Antiviral Assay Based on a Sindbis Virus-GFP for the Discovery of Inhibitors of Alphavirus Replication [PDF]

Viruses
The re-emergence of alphaviruses (family Togaviridae), such as chikungunya virus, poses significant public health risks, with direct impact on quality of life and work productivity.
Gabriel Augusto Pires de Souza, Rana Abdelnabi, Bert Vanmechelen, Leni Van Eyck, Nelleke Cloet, Deniz Öner, Dirk Roymans, Aleksandra Siekierska, Koert Stittelaar, Johan Neyts   +9 more
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In silico reconstruction of a salmonid alphavirus virion reveals distinctive molecular features implicated in virulence [PDF]

iScience
Summary: Salmonid alphavirus (SAV) poses a significant disease threat to aquaculture. Recently, new alphaviruses from several fish species have been discovered. However, little is known about their biology and pathogenicity.
Stéphane Biacchesi, Calvin Fauvet, Emilie Mérour, Julie Bernard, Annie Lamoureux, Delphine Lallias, Jean K. Millet   +6 more
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A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
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LDL Receptor in Alphavirus Entry: Structural Analysis and Implications for Antiviral Therapy

Nature Communications
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor
Michael Veit, Felix Rey
exaly   +2 more sources

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
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An Investigation of Culicoides (Diptera: Ceratopogonidae) as Potential Vectors of Medically and Veterinary Important Arboviruses in South Africa

Viruses, 2021
Culicoides-borne viruses such as bluetongue, African horse sickness, and Schmallenberg virus cause major economic burdens due to animal outbreaks in Africa and their emergence in Europe and Asia.
Jumari Snyman, Gert J. Venter, Marietjie Venter   +2 more
doaj   +1 more source

Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells

Microbiology Spectrum, 2023
Most alphaviruses are transmitted by mosquito vectors and infect a wide range of vertebrate hosts, with a few exceptions. Eilat virus (EILV) in this genus is characterized by a host range restricted to mosquitoes. Its chimeric viruses have been developed
Lu Tan, Yiwen Zhang, Dal Young Kim, Runsheng Li   +3 more
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