Sequelae and Animal Modeling of Encephalitic Alphavirus Infections [PDF]
Viruses, 2023 Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe ...
Rachel A. Reyna, Scott C. Weaver
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Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages [PDF]
mSphere, 2018 Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith +10 more
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Alphavirus Virulence Determinants
Pathogens, 2021 Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel +1 more
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Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis [PDF]
Journal of Virology, 2018 ABSTRACT Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited. Mosquito vectors such as Aedes and Culex
Siew-Wai Fong +2 more
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Neurological Sequelae Resulting from Encephalitic Alphavirus Infection [PDF]
Frontiers in Microbiology, 2016 The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA viruses in the Togaviridae family.
Slobodan Paessler, Kelly Dineley
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Viruses, 2019 Background: Alphaviruses are transmitted by arthropod vectors and can be found worldwide. Alphaviruses of the Semliki Forest complex such as chikungunya virus (CHIKV), Mayaro virus (MAYV) or Ross River virus (RRV) cause acute febrile illness and long ...
Lisa Henss +8 more
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Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections [PDF]
Pathogens, 2021 Kylene Kehn-Hall +2 more
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Gut microbe–derived short-chain fatty acids regulate alphavirus arthritis and macrophage activation in mice [PDF]
The Journal of Clinical InvestigationOral antibiotics can predispose to joint inflammation, but this phenomenon remains poorly understood. Here, we leverage mouse models of alphavirus-induced arthritis to investigate the roles of gut commensals, metabolites, and host immune mechanisms in ...
Fang R. Zhao +19 more
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Mosquito-borne viral infections: veterinary diagnostic approach with a One Health perspective [PDF]
Journal of Clinical MicrobiologyThe diagnosis of mosquito-borne viral infectious diseases can be challenging, in part due to the complexity of antibody cross-reactivity between many of these viruses.
Nicholas K. Y. Yuen
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