Sequelae and Animal Modeling of Encephalitic Alphavirus Infections [PDF]
Viruses, 2023 Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe ...
Rachel A. Reyna, Scott C. Weaver
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Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages [PDF]
mSphere, 2018 Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith +10 more
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Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. [PDF]
PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
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Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
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Impact of mutations affecting 4′-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus [PDF]
Journal of VirologyVenezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals.
Jenny Wong +10 more
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Mosquito-borne viral infections: veterinary diagnostic approach with a One Health perspective [PDF]
Journal of Clinical MicrobiologyThe diagnosis of mosquito-borne viral infectious diseases can be challenging, in part due to the complexity of antibody cross-reactivity between many of these viruses.
Nicholas K. Y. Yuen
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Venezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity [PDF]
npj VirusesVenezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus that causes severe neuroinflammation and fatal infections in some people. Numerous outbreaks of VEEV have been reported in Latin America in the past century. Though mosquito-borne,
Kenneth C. Elliott +2 more
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Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller +9 more
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Molecular and cellular evidence of natural Venezuelan equine encephalitis virus infection in frugivorous bats in Colombia [PDF]
Veterinary World, 2020 Background and Aim: Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes encephalitis with a high impact on public health in Latin America.
Camilo Guzmán +6 more
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Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
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