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Innate immune control of alphavirus infection [PDF]
Current Opinion in Virology, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Kathryn S, Carpentier +1 more
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Effect of alphavirus infection on mouse embryos [PDF]
Infection and Immunity, 1982 Seven strains and mutants of the alphaviruses, Semliki Forest virus and Sindbis virus, differed in their lethality for mouse embryos and their mothers. The A7 strain and the neurovirulence mutant M103 of Semliki Forest virus were selected for detailed comparison. A7 produced 100% lethality of mouse embryos but was avirulent for their mothers.
Atkins, G J, Carter, J, Sheahan, B J
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Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall [PDF]
Journal of Virology, 2021 Abstract The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a ...
Lana Langendries +7 more
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Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1. [PDF]
Adv Sci (Weinh)Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Zhang Y +10 more
europepmc +2 more sources
Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines
Molecules, 2022 The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen +5 more
doaj +1 more source
Occurrence of salmonid alphavirus and piscine orthoreovirus-1 infections in migrating salmon (Salmo salar L.) post-smolt in western Norway [PDF]
, 2023 Viral diseases are a serious problem in Atlantic salmon (Salmo salar L.) farming in Norway, often leading to reduced fish welfare and increased mortality.
Karlsbakk, Egil Erlingsson +4 more
core +1 more source
PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
doaj +1 more source
Viruses, 2023 Alphaviruses are serious zoonotic threats responsible for significant morbidity, causing arthritis or encephalitis. So far, no licensed drugs or vaccines are available to combat alphaviral infections.
Amrita Saha +5 more
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Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006
Emerging Infectious Diseases, 2010 Mother-to-child transmission of chikungunya virus was reported during the 2005–2006 outbreak on Réunion Island, France. To determine the effects of this virus on pregnancy outcomes, we conducted a study of pregnant women in Réunion in 2006.
Xavier Fritel +15 more
doaj +1 more source
The Host Non-Coding RNA Response to Alphavirus Infection
Viruses, 2023 Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
openaire +3 more sources