Results 41 to 50 of about 819,223 (194)

Alphavirus infection triggers antiviral RNAi immunity in mammals

Cell Reports, 2023
RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting its scope as a mammalian immunity.
Jing Kong, Yuanyuan Bie, Wenting Ji, Jiuyue Xu, Bao Lyu, Xiaobei Xiong, Yang Qiu, Xi Zhou   +7 more
openaire   +3 more sources

Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells

mBio, 2017
Sindbis virus (SINV [genus Alphavirus, family Togaviridae]) is an enveloped, mosquito-borne virus. Alphaviruses cause cytolytic infections in mammalian cells while establishing noncytopathic, persistent infections in mosquito cells.
Joyce Jose, Aaron B. Taylor, Richard J. Kuhn   +2 more
doaj   +1 more source

Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]

Journal of Virology, 2015
ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
K J, Sokoloski, K C, Haist, T E, Morrison, S, Mukhopadhyay, R W, Hardy   +4 more
openaire   +2 more sources

Early Events in Alphavirus Replication Determine the Outcome of Infection [PDF]

Journal of Virology, 2012
ABSTRACT Alphaviruses are a group of important human and animal pathogens. They efficiently replicate to high titers in vivo and in many commonly used cell lines of vertebrate origin. They have also evolved effective means of interfering with development of the innate immune
Ilya, Frolov, Maryna, Akhrymuk, Ivan, Akhrymuk, Svetlana, Atasheva, Elena I, Frolova   +4 more
openaire   +2 more sources

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases.

PLoS ONE, 2021
The potential outcome of flavivirus and alphavirus co-infections is worrisome due to the development of severe diseases. Hundreds of millions of people worldwide live under the risk of infections caused by viruses like chikungunya virus (CHIKV, genus ...
Raphael J Eberle, Danilo S Olivier, Carolina C Pacca, Clarita M S Avilla, Mauricio L Nogueira, Marcos S Amaral, Dieter Willbold, Raghuvir K Arni, Monika A Coronado   +8 more
doaj   +1 more source

Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases

Microorganisms, 2022
Several neurotropic viruses are members of the flavivirus and alphavirus families. Infections caused by these viruses may cause long-term neurological sequelae in humans.
Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Carolina C. Pacca, Mauricio L. Nogueira, Raghuvir K. Arni, Dieter Willbold, Monika A. Coronado   +7 more
doaj   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

Impact of bauxite mining on mosquito communities (Diptera: Culicidae) and pathogen transmission risks in the eastern Amazon

Medical and Veterinary Entomology, EarlyView.
Bauxite mining in the Amazon alters mosquito communities, favouring anthropophilic and generalist vectors while reducing species diversity and the variety of blood meal sources. Molecular analyses identified humans, tapirs and deer as the primary blood meal sources.
Mayron Mielly Morais Pacheco, Poliana da Silva Lemos, Mônica Silva Coelho, Tatiane Marques Porangaba de Oliveira, Luciano Chaves Franco Filho, Øystein Wiig, Ana Cristina Mendes‐Oliveira, Leonardo Sena, Maria Anice Mureb Sallum   +8 more
wiley   +1 more source

Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.

PLoS Neglected Tropical Diseases, 2017
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud   +9 more
doaj   +1 more source