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Alphavirus-Based Vaccines [PDF]
Viruses, 2014 Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
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Alphavirus Virulence Determinants [PDF]
Pathogens, 2021 Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel +1 more
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Salmonid alphavirus (SAV) [PDF]
Journal of Veterinary Research, 2018 Salmonid alphavirus (SAV), genus Alphavirus, family Togaviridae, is a single-stranded RNA virus affecting Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). It is known to be responsible for pancreas disease (PD) and sleeping disease (
Deperasińska Izabela +2 more
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Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia [PDF]
Virus Research, 2018 Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes.
Yongjin Qiu +2 more
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A molecular understanding of alphavirus entry. [PDF]
PLoS Pathogens, 2020 Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes +3 more
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Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Microorganisms, 2021 Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Lisa Ng
exaly +4 more sources
Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering [PDF]
Journal of VirologyAlphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici +3 more
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Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
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Asymmetric structural transitions in the icosahedral organization of Eastern equine encephalitis virus [PDF]
Nature CommunicationsDelivery of the viral genome into host cells is a critical step in successful viral infection. Alphaviruses achieve this step by fusing the viral and endosomal membranes under acidic conditions. This process requires significant structural changes in the
Abhishek Bandyopadhyay +5 more
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Current perspectives on alphavirus encapsidation, assembly and budding [PDF]
Frontiers in Cellular and Infection MicrobiologyAlphaviruses are an escalating global concern due to their considerable clinical impact and expanding geographic distribution. Transmitted primarily through the bites of infected mosquitoes, alphaviruses cause a wide spectrum of arthritogenic and ...
Kanchan Bhardwaj +4 more
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