Results 1 to 10 of about 15,159 (204)
Alphavirus-Based Vaccines [PDF]
Viruses, 2014 Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
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Alphavirus Virulence Determinants [PDF]
Pathogens, 2021 Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel +1 more
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Salmonid alphavirus (SAV) [PDF]
Journal of Veterinary Research, 2018 Salmonid alphavirus (SAV), genus Alphavirus, family Togaviridae, is a single-stranded RNA virus affecting Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). It is known to be responsible for pancreas disease (PD) and sleeping disease (
Deperasińska Izabela +2 more
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Arthritogenic Alphavirus Capsid Protein
Life, 2021 In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
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Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia [PDF]
Virus Research, 2018 Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes.
Shiho Torii +2 more
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A molecular understanding of alphavirus entry.
PLoS Pathogens, 2020 Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes +3 more
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Alphavirus Entry and Membrane Fusion [PDF]
Viruses, 2010 The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell. The membrane fusion proteins of the alphaviruses and flaviviruses have many similarities in structure and function.
Margaret Kielian +2 more
exaly +5 more sources
Plasmid DNA-based Alphavirus Vaccines
Vaccines, 2019 Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
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Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
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Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly
mBio, 2020 Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan +2 more
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