Results 1 to 10 of about 16,582 (211)
A molecular understanding of alphavirus entry [PDF]
PLoS Pathogens, 2020 Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Katherine Basore +2 more
exaly +7 more sources
Arthritogenic Alphavirus Capsid Protein
Life, 2021 In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
doaj +2 more sources
Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering [PDF]
Journal of VirologyAlphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici +3 more
doaj +2 more sources
Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
doaj +2 more sources
Asymmetric structural transitions in the icosahedral organization of Eastern equine encephalitis virus [PDF]
Nature CommunicationsDelivery of the viral genome into host cells is a critical step in successful viral infection. Alphaviruses achieve this step by fusing the viral and endosomal membranes under acidic conditions. This process requires significant structural changes in the
Abhishek Bandyopadhyay +5 more
doaj +2 more sources
Current perspectives on alphavirus encapsidation, assembly and budding [PDF]
Frontiers in Cellular and Infection MicrobiologyAlphaviruses are an escalating global concern due to their considerable clinical impact and expanding geographic distribution. Transmitted primarily through the bites of infected mosquitoes, alphaviruses cause a wide spectrum of arthritogenic and ...
Kanchan Bhardwaj +4 more
doaj +2 more sources
Viruses, 2021 Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated to mediate many virus–host protein–protein interactions in several fundamental
Nurshariza Abdullah +8 more
doaj +1 more source
Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundstrom
doaj +1 more source
Viruses, 2022 Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko +4 more
doaj +1 more source
Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
doaj +1 more source