Results 21 to 30 of about 15,159 (204)
One HealthSummary: Flavivirus (family Flaviviridae) and Alphavirus (family Togaviridae) are mosquito-borne viruses that poses a significant risk to public health worldwide.
Aaron Yeh-Gorocica +14 more
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VirusesAdvances in diagnostic techniques coupled with ongoing environmental changes have resulted in intensified surveillance and monitoring of arbovirus circulation in the Amazon.
Bruna Ramos +17 more
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Alphavirus vectors for cancer therapy
Virus Research, 2010 Alphaviruses contain a single strand RNA genome that can be easily modified to express heterologous genes at very high levels in a broad variety of cells, including tumor cells. Alphavirus vectors can be used as viral particles containing a packaged vector RNA, or directly as nucleic acids in the form of RNA or DNA. In the latter case alphavirus RNA is
JOSÉ I Quetglas +2 more
exaly +3 more sources
Alphavirus Nonstructural Proteases and Their Inhibitors
, 2017 Alphaviruses, such as Chikungunya virus, O’Nyong–Nyong virus, Ross River virus, have been widely known to cause fever, rash, and rheumatic diseases. In addition, several other alphaviruses, for instance Eastern equine encephalitis virus, Venezuelan equine encephalitis virus, and Western equine encephalitis virus, potentially cause fatal encephalitis in
Bissoyi, A.; id_orcid 0000-0002-0909-8556 +6 more
openaire +3 more sources
Ly6C+ monocytes in the skin promote systemic alphavirus dissemination
Cell ReportsSummary: Alphaviruses are mosquito-transmitted pathogens that induce high levels of viremia, which facilitates dissemination and vector transmission. One prevailing paradigm is that, after skin inoculation, alphavirus-infected resident dendritic cells ...
Autumn C. Holmes +6 more
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Viruses, 2021 Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated to mediate many virus–host protein–protein interactions in several fundamental
Nurshariza Abdullah +8 more
doaj +1 more source
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]
Journal of Virology, 2013 ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay +4 more
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Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundstrom
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Viruses, 2022 Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko +4 more
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Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
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