Results 21 to 30 of about 16,243 (206)
Viruses, 2021 Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated to mediate many virus–host protein–protein interactions in several fundamental
Nurshariza Abdullah +8 more
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Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundstrom
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A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]
Journal of Virology, 2013 ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay +4 more
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Viruses, 2022 Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko +4 more
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Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
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Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller +9 more
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Viruses, 2023 Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen +4 more
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Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]
, 2007 Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K +11 more
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Improved detection of genus-specific Alphavirus using a generic TaqMan® assay
BMC Microbiology, 2017 Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry +4 more
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Viruses, 2015 Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
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