Results 21 to 30 of about 23,819 (265)
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]
Journal of Virology, 2013 ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay +4 more
openaire +2 more sources
A molecular understanding of alphavirus entry.
PLoS Pathogens, 2020 Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes +3 more
doaj +1 more source
The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]
, 2018 The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S +6 more
core +2 more sources
Viruses, 2023 Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen +4 more
doaj +1 more source
Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]
, 2018 Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel +13 more
core +3 more sources
Viruses, 2015 Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj +1 more source
Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly
mBio, 2020 Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan +2 more
doaj +1 more source
Alphavirus Identification in Neotropical Bats [PDF]
Viruses, 2022 Alphaviruses (Togaviridae) are arthropod-borne viruses responsible for several emerging diseases, maintained in nature through transmission between hematophagous arthropod vectors and susceptible vertebrate hosts. Although bats harbor many species of viruses, their role as reservoir hosts in emergent zoonoses has been verified only in a few cases. With
Lucía Moreira Marrero +3 more
openaire +4 more sources
Improved detection of genus-specific Alphavirus using a generic TaqMan® assay
BMC Microbiology, 2017 Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry +4 more
doaj +1 more source
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
doaj +1 more source