Results 21 to 30 of about 16,582 (211)

Mosquitoes as Vectors of Mycobacterium ulcerans Based on Analysis of Notifications of Alphavirus Infection and Buruli Ulcer, Victoria, Australia

Emerging Infectious Diseases
Alphavirus infections are transmitted by mosquitoes, but the mode of transmission for Mycobacterium ulcerans, which causes Buruli ulcer, is contested. Using notification data for Victoria, Australia, during 2017–2022, adjusted for incubation period, we ...
Andrew H. Buultjens, Ee Laine Tay, Aidan Yuen, N. Deborah Friedman, Timothy P. Stinear, Paul D.R. Johnson   +5 more
doaj   +2 more sources

The First Isolation of Insect-Specific Alphavirus (Agua Salud alphavirus) in Culex (Melanoconion) Mosquitoes in the Brazilian Amazon

Viruses
Advances in diagnostic techniques coupled with ongoing environmental changes have resulted in intensified surveillance and monitoring of arbovirus circulation in the Amazon.
Bruna Ramos, Valéria Carvalho, Eliana da Silva, Maria Freitas, Landeson Junior Barros, Maissa Santos, Jamilla Augusta Pantoja, Ercília Gonçalves, Joaquim Nunes Neto, José Wilson Junior, Durval Vieira, Daniel Dias, Ana Cecília Cruz, Bruno Nunes, Sandro Silva, Carine Aragão, Alexandre Casseb, Lívia Martins   +17 more
doaj   +2 more sources

Ly6C+ monocytes in the skin promote systemic alphavirus dissemination [PDF]

Cell Reports
Summary: Alphaviruses are mosquito-transmitted pathogens that induce high levels of viremia, which facilitates dissemination and vector transmission. One prevailing paradigm is that, after skin inoculation, alphavirus-infected resident dendritic cells ...
Autumn C. Holmes, Cormac J. Lucas, Morgan E. Brisse, Brian C. Ware, Heather D. Hickman, Thomas E. Morrison, Michael S. Diamond   +6 more
doaj   +2 more sources

A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]

Journal of Virology, 2013
ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay, Eryu, Wang, Robert, Seymour, Scott C, Weaver, John K, Rose   +4 more
openaire   +2 more sources

Alphavirus structure

, 2023
An illustration of the structure of an alphavirus, including structural proteins. Created by me in Illustrator.
Robert Lawrence (17410479)
core   +1 more source

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]

, 2007
Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K, Tamberg, Nele, Merits, Andres, Fazakerley, JK, Fragkoudis, R, Lulla, V, Lulla, Valeria, Lulla, A, Merits, A, Tamberg, N, Fragkoudis, Rennos, Lulla, Aleksei   +11 more
core   +1 more source

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence

Viruses, 2023
Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen, Kelly S. Aldana, Emily Yang, Zhenlan Yao, Melody M. H. Li   +4 more
doaj   +1 more source

Eugenol-Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights. [PDF]

J Med Virol
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Reis ACC, Silva ALSD, Portruneli C, Silva AVP, Braga SFP, Lapa IR, Souza TB, Franco LL, Carvalho DT, Brandão GC.   +9 more
europepmc   +2 more sources

Alphaviruses in Gene Therapy

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +1 more source