Results 21 to 30 of about 13,766 (218)
Improved detection of genus-specific Alphavirus using a generic TaqMan® assay
BMC Microbiology, 2017 Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry +4 more
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Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly
mBio, 2020 Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan +2 more
doaj +1 more source
Viruses, 2023 Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen +4 more
doaj +1 more source
Viruses, 2015 Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj +1 more source
Alphavirus Identification in Neotropical Bats [PDF]
Viruses, 2022 Alphaviruses (Togaviridae) are arthropod-borne viruses responsible for several emerging diseases, maintained in nature through transmission between hematophagous arthropod vectors and susceptible vertebrate hosts. Although bats harbor many species of viruses, their role as reservoir hosts in emergent zoonoses has been verified only in a few cases. With
Lucía Moreira Marrero +3 more
openaire +5 more sources
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
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PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
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Plasmid DNA-based Alphavirus Vaccines
Vaccines, 2019 Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
doaj +1 more source
The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. [PDF]
PLoS ONE, 2013 Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune
Maria L Knudsen +9 more
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Alphavirus polymerase and RNA replication [PDF]
Virus Research, 2017 Alphaviruses are typically arthropod-borne, and many are important pathogens such as chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1-4), initially produced as a polyprotein P1234. nsP4 is the core RNA-dependent RNA polymerase but all four nsPs are required for RNA synthesis.
Maija K, Pietilä +2 more
openaire +2 more sources