Relapse of polymyalgia rheumatica following adjuvanted influenza vaccine: A case-based review [PDF]
, 2020 Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatological condition affecting individuals aged >50 years. There have been rare reports of PMR and other vasculitides developing within 3 months of influenza vaccination.
Bassendine, Margaret F., Bridge, Simon
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Apoptosis in Alphavirus Encephalitis
Seminars in Virology, 1998 Abstract Sindbis virus causes acute encephalitis in mice and serves as a useful model for encephalitic alphaviruses that infect humans. The outcome of infection is determined by whether infected neurons are resistant to virus-induced programmed cell death or activate their apoptotic pathway.
Diane E. Griffin, J. Marie Hardwick
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The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. [PDF]
PLoS ONE, 2013 Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune
Maria L Knudsen +9 more
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Selective precipitation reaction: a novel diagnostic test for tissue pathology in Atlantic Salmon, Salmo salar, infected with Salmonid Alpha-Virus (SAV3) [PDF]
, 2017 While investigating biomarkers for infection with salmonid alphavirus (SAV), the cause of pancreas disease (PD), a selective precipitation reaction (SPR) has been discovered in serum which could be an on-farm qualitative test and an in-laboratory ...
Adams +20 more
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The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
, 2016 Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S +4 more
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Alphavirus Restriction by
Traffic, 2016 Interferon inducible transmembrane proteins (IFITMs) are broad‐spectrum antiviral factors. In cell culture the entry of many enveloped viruses, including orthomyxo‐, flavi‐, and filoviruses, is inhibited by IFITMs, though the mechanism(s) involved remain unclear and may vary between viruses.
Weston, S +7 more
openaire +5 more sources
Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Microorganisms, 2021 Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta +2 more
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Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses [PDF]
, 2017 The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies.
Donald, Claire L. +4 more
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ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]
, 2019 Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea +6 more
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Interactions of Alphavirus nsP3 Protein with Host Proteins
Frontiers in Microbiology, 2018 Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark +2 more
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