, 2023 An illustration of the structure of an alphavirus, including structural proteins. Created by me in Illustrator.
Robert Lawrence (17410479)
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Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]
, 2010 Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M. +34 more
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Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]
PLoS Neglected Tropical Diseases, 2010 Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
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Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses [PDF]
, 2022 Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern.
Liu, Xiang +5 more
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PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
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PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]
, 2009 The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R. +20 more
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Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
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The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. [PDF]
PLoS ONE, 2013 Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune
Maria L Knudsen +9 more
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Entry receptors - The gateway to alphavirus infection [PDF]
, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past
Zimmerman, Ofer +9 more
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Host-pathogen interactions during alphavirus infection
, 2021 Arthritogenic alphavirus infection causes debilitating pain in the joints and muscles with many patients experiencing such symptoms chronically. However, there is insufficient evidence to explain the underlying causes behind symptoms of persistent ...
Lim, Elisa X
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