Results 31 to 40 of about 15,159 (204)

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Alphaviruses in Gene Therapy

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +1 more source

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence

Viruses, 2023
Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen, Kelly S. Aldana, Emily Yang, Zhenlan Yao, Melody M. H. Li   +4 more
doaj   +1 more source

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]

, 2007
Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K, Tamberg, Nele, Merits, Andres, Fazakerley, JK, Fragkoudis, R, Lulla, V, Lulla, Valeria, Lulla, A, Merits, A, Tamberg, N, Fragkoudis, Rennos, Lulla, Aleksei   +11 more
core   +1 more source

Improved detection of genus-specific Alphavirus using a generic TaqMan® assay

BMC Microbiology, 2017
Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque, Marie-Christine Jaffar-Bandjee   +4 more
doaj   +1 more source

Alphavirus Identification in Neotropical Bats [PDF]

Viruses, 2022
Alphaviruses (Togaviridae) are arthropod-borne viruses responsible for several emerging diseases, maintained in nature through transmission between hematophagous arthropod vectors and susceptible vertebrate hosts. Although bats harbor many species of viruses, their role as reservoir hosts in emergent zoonoses has been verified only in a few cases. With
Lucía Moreira Marrero, Germán Botto Nuñez, Sandra Frabasile, Adriana Delfraro   +3 more
openaire   +5 more sources

Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses [PDF]

, 2022
Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern.
Liu, Xiang, Patrick Chun Hean Tang, Hean Tang, Patrick Chun, Hann Ng, Wern, Wern Hann Ng, Xiang Liu   +5 more
core   +1 more source

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]

PLoS Pathogens, 2012
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani, Michael R Wiley, Marta G Murreddu, Zach N Adelman, Kevin M Myles   +4 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Alphavirus structure

, 2023
An illustration of the structure of an alphavirus, including structural proteins. Created by me in Illustrator.
Robert Lawrence (17410479)
core   +1 more source