Results 1 to 10 of about 171,370 (219)

Therapeutic and prophylactic applications of self-replicating RNA viruses

Exploration of Immunology, 2022
Self-replicating RNA viruses have been commonly used for preventive and therapeutic interventions in the fields of infectious diseases and cancers. Both RNA viruses with single-stranded RNA genomes of positive and negative polarity have been utilized ...
Kenneth Lundstrom
doaj   +1 more source

Alphaviruses in Immunotherapy and Anticancer Therapy

Biomedicines, 2022
Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundstrom
doaj   +1 more source

Alphaviruses in Cancer Therapy

Frontiers in Molecular Biosciences, 2022
Alphaviruses have been engineered as expression vectors for different strategies of cancer therapy including immunotherapy and cancer vaccine development.
Kenneth Lundstrom
doaj   +1 more source

First Recombinant High-Density Lipoprotein Particles Administration in a Severe ICU COVID-19 Patient, a Multi-Omics Exploratory Investigation

Biomedicines, 2022
High-density lipoproteins (HDLs) have multiple endothelioprotective properties. During SARS-CoV-2 infection, HDL-cholesterol (HDL-C) concentration is markedly reduced, and studies have described severe impairment of the functionality of HDL particles ...
Sébastien Tanaka, Floran Begue, Bryan Veeren, Alexy Tran-Dinh, Tiphaine Robert, Parvine Tashk, Brice Lortat-Jacob, Dorothée Faille, Luc de Chaisemartin, Nathalie Zappella, Enora Atchade, Laura Kramer, Philippe Montravers, Olivier Meilhac   +13 more
doaj   +1 more source

A replicative recombinant HPV16 E7 expression virus upregulates CD36 in C33A cells

Frontiers in Microbiology, 2023
ObjectiveIn past decades, the role of high-risk HPV (HR-HPV) infection in cancer pathogenesis has been extensively studied. The viral E7 protein expressed in pre-malignant cells has been identified as an ideal target for immunological intervention ...
Yunting Shao, Peng Wang, Yunji Zheng, Hongtu Cui, Zhangrong Lou, Shanhu Li, Fang Huang, Chengjun Wu   +7 more
doaj   +1 more source

Production of Influenza Virus Proteins Using Recombinant Insect Cells [PDF]

MATEC Web of Conferences, 2021
Influenza vaccines have long been manufactured in embryonated chicken eggs. This method has some problems such as a long production period (about 6 months) and use of large amounts of infectious pathogens.
Matsuda Takuya, Tanijima Toshikazu, Masumi-Koizumi Kyoko, Katsuda Tomohisa, Yamaji Hideki   +4 more
doaj   +1 more source

Recombinant ferritins for multimodal nanomedicine

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In all living organisms, ferritins are a group of proteins important for maintaining iron homeostasis. Increasing amount of studies has shown that recombinant ferritins can be widely used in multimodal nanomedicine, especially for anticancer treatment ...
Yihao Li, Haoyu Gao, Eugenie Nepovimova, Qinghua Wu, Vojtech Adam, Kamil Kuca   +5 more
doaj   +1 more source

Preparation of Class Y Immunoglobulins that Neutralize the Marburg Virus

Проблемы особо опасных инфекций, 2021
The aim was to study the possibility of inducing Marburg-neutralizing chicken antibodies (MARV) using various immunogens.Materials and methods. Recombinant vaccinia virus expressing the surface glycoprotein (GP) transgene MARV of Musoke strain and ...
O. A. Polezhaeva, A. V. Zybkina, A. V. Zaikovskaya, O. V. P’yankov, S. A. P’yankov, A. V. Semenova, G. V. Semenova, D. N. Shcherbakov   +7 more
doaj   +1 more source

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. [PDF]

PLoS Neglected Tropical Diseases, 2015
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Miriam Bolz, Sarah Kerber, Gert Zimmer, Gerd Pluschke   +3 more
doaj   +1 more source

Alphavirus-Based Vaccines

Viruses, 2014
Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
doaj   +1 more source