Results 41 to 50 of about 16,582 (211)

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies [PDF]

Alphaviruses are re-emerging vector-born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there ...
Merits, Andres, Wang, Sainan, Mahalingam, Suresh   +2 more
core   +1 more source

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Impact of bauxite mining on mosquito communities (Diptera: Culicidae) and pathogen transmission risks in the eastern Amazon

Medical and Veterinary Entomology, EarlyView.
Bauxite mining in the Amazon alters mosquito communities, favouring anthropophilic and generalist vectors while reducing species diversity and the variety of blood meal sources. Molecular analyses identified humans, tapirs and deer as the primary blood meal sources.
Mayron Mielly Morais Pacheco, Poliana da Silva Lemos, Mônica Silva Coelho, Tatiane Marques Porangaba de Oliveira, Luciano Chaves Franco Filho, Øystein Wiig, Ana Cristina Mendes‐Oliveira, Leonardo Sena, Maria Anice Mureb Sallum   +8 more
wiley   +1 more source

ANALISIS MODEL MATEMATIKA PENGUJI EFEKTIVITAS ONCOLYTIC PADA ALPHAVIRUS [PDF]

, 2019
Kanker merupakan salah satu penyakit penyebab kematian dengan jumlah terbesar di seluruh dunia. Oncolotyc virotherapy adalah metode pengobatan yang menggunakan replikasi virus sebagai agen antineoplastik yang selektif, yang masih dalam tahap ...
RAHMAWATI NUR FADZILLAH, 081211233030
core   +1 more source

Dancing with the Devil: A Review of the Importance of Host RNA-Binding Proteins to Alphaviral RNAs during Infection

Viruses, 2023
Alphaviruses are arthropod-borne, single-stranded positive sense RNA viruses that rely on the engagement of host RNA-binding proteins to efficiently complete the viral lifecycle.
Claire E. Westcott, Cierra M. Isom, Deepa Karki, Kevin J. Sokoloski   +3 more
doaj   +1 more source

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Virome Identification and Characterization of Fusarium sacchari and F. andiyazi: Causative Agents of Pokkah Boeng Disease in Sugarcane

Frontiers in Microbiology, 2020
Fusarium sacchari and Fusarium andiyazi are two devastating sugarcane pathogens that cause pokkah boeng disease (PBD) in China. RNA_Seq was conducted to identify mycoviruses in F. sacchari and F.
Ziting Yao, Ziting Yao, Chengwu Zou, Chengwu Zou, Na Peng, Na Peng, Yu Zhu, Yixue Bao, Yixue Bao, Qiujuan Zhou, Qiujuan Zhou, Qingfa Wu, Baoshan Chen, Baoshan Chen, Muqing Zhang, Muqing Zhang   +15 more
doaj   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

Alphavirus structure: activation for entry at the target cell surface

, 2013
International audienceA wealth of new data about the 3D organization of alphavirus particles was obtained in the last few years. This includes the crystal structures of the envelope glycoprotein complexes at neutral and at acid pH, as well as electron ...
Rey, Felix, Vaney, Marie-Christine, Duquerroy, Stephane   +2 more
core   +1 more source