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Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies [PDF]
Alphaviruses are re-emerging vector-born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there ...
Merits, Andres +2 more
core +1 more source
First Record of Mosquito-Borne Kyzylagach Virus in Central Europe
Viruses, 2020 RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová +8 more
doaj +1 more source
Structure and Replication of Alphavirus RNAs [PDF]
, 1982 Both ends of the alphavirus genomic RNA are potentially important in its replication. The region preceding and including the 5'-end of the subgenomic 26S RNA in genomic RNA might also be involved in 26S RNA transcription. Sequences of these regions of up
Ou, Jing-hsiung James
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Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove +7 more
wiley +1 more source
Viruses, 2023 Alphaviruses are arthropod-borne, single-stranded positive sense RNA viruses that rely on the engagement of host RNA-binding proteins to efficiently complete the viral lifecycle.
Claire E. Westcott +3 more
doaj +1 more source
Medical and Veterinary Entomology, EarlyView.Bauxite mining in the Amazon alters mosquito communities, favouring anthropophilic and generalist vectors while reducing species diversity and the variety of blood meal sources. Molecular analyses identified humans, tapirs and deer as the primary blood meal sources.
Mayron Mielly Morais Pacheco +8 more
wiley +1 more source
Alphavirus structure: activation for entry at the target cell surface
, 2013 International audienceA wealth of new data about the 3D organization of alphavirus particles was obtained in the last few years. This includes the crystal structures of the envelope glycoprotein complexes at neutral and at acid pH, as well as electron ...
Rey, Felix +2 more
core +1 more source
Frontiers in Microbiology, 2020 Fusarium sacchari and Fusarium andiyazi are two devastating sugarcane pathogens that cause pokkah boeng disease (PBD) in China. RNA_Seq was conducted to identify mycoviruses in F. sacchari and F.
Ziting Yao +15 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade +13 more
wiley +1 more source