Results 41 to 50 of about 15,159 (204)
Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]
PLoS Neglected Tropical Diseases, 2010 Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
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PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
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PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]
, 2009 The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R. +20 more
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The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. [PDF]
PLoS ONE, 2013 Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune
Maria L Knudsen +9 more
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Synthesis of Alphavirus-Specified RNA [PDF]
Journal of Virology, 1978 UV irradiation of chicken fibroblasts infected with Semliki Forest or Sindbis virus has been used to investigate the mechanism of synthesis of 42S and 26S RNA, the major plus-strand virus-specified RNAs formed during the multiplication of standard virus particles.
H, Brzeski, S I, Kennedy
openaire +2 more sources
Alphavirus polymerase and RNA replication [PDF]
Virus Research, 2017 Alphaviruses are typically arthropod-borne, and many are important pathogens such as chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1-4), initially produced as a polyprotein P1234. nsP4 is the core RNA-dependent RNA polymerase but all four nsPs are required for RNA synthesis.
Maija K, Pietilä +2 more
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Imaging the Alphavirus Exit Pathway [PDF]
Journal of Virology, 2014 ABSTRACT Alphaviruses are small enveloped RNA viruses with highly organized structures that exclude host cell proteins. They contain an internal nucleocapsid and an external lattice of the viral E2 and E1 transmembrane proteins. Alphaviruses bud from the plasma membrane (PM), but the process and dynamics of alphavirus assembly and budding are
Maria Guadalupe, Martinez +4 more
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Host-pathogen interactions during alphavirus infection
, 2021 Arthritogenic alphavirus infection causes debilitating pain in the joints and muscles with many patients experiencing such symptoms chronically. However, there is insufficient evidence to explain the underlying causes behind symptoms of persistent ...
Lim, Elisa X
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Genetic control of alphavirus pathogenesis [PDF]
Mammalian Genome, 2018 Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus ...
Victoria K. Baxter, Mark T. Heise
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First Record of Mosquito-Borne Kyzylagach Virus in Central Europe
Viruses, 2020 RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová +8 more
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