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Research trends on alphavirus receptors: a bibliometric analysis [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundAlphaviruses are a diverse group of pathogens that have garnered considerable attention due to their impact on human health. By investigating alphavirus receptors, researchers can elucidate viral entry mechanisms and gain important clues for ...
Runqi Chen +7 more
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Viruses, 2019 Arthritogenic alphaviruses are a group of medically important arboviruses that cause inflammatory musculoskeletal disease in humans with debilitating symptoms, such as arthralgia, arthritis, and myalgia.
Helen Mostafavi +3 more
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Interactions of Alphavirus nsP3 Protein with Host Proteins
Frontiers in Microbiology, 2018 Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark +2 more
doaj +2 more sources
, 2016 The family Togaviridae consists of two genera, Alphavirus and Rubivirus (Fields et al., 2013). The organization of their respective genomes is similar, but phylogenetic analysis shows that alphaviruses and rubiviruses are quite divergent (Koonin and ...
Lark L. Coffey +2 more
openaire +2 more sources
Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World [PDF]
Journal of General Virology, 2020 The genus Alphavirus harbours mostly insect- transmitted viruses that cause severe disease in humans, livestock and wildlife. Thus far, only three alphaviruses with a host range restricted to insects have been found in mosquitoes from the Old World ...
Marco Marklewitz +2 more
exaly +2 more sources
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1. [PDF]
Adv Sci (Weinh)Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Zhang Y +10 more
europepmc +2 more sources
Current perspectives on alphavirus encapsidation, assembly and budding [PDF]
Frontiers in Cellular and Infection MicrobiologyAlphaviruses are an escalating global concern due to their considerable clinical impact and expanding geographic distribution. Transmitted primarily through the bites of infected mosquitoes, alphaviruses cause a wide spectrum of arthritogenic and ...
Kanchan Bhardwaj +4 more
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Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Microorganisms, 2021 Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta +2 more
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Alphavirus Nucleocapsid Packaging and Assembly [PDF]
Viruses, 2018 Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve.
Adriano Mendes +2 more
exaly +4 more sources
Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner [PDF]
Frontiers in ImmunologyIntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed +10 more
doaj +2 more sources