Results 11 to 20 of about 23,819 (265)
Alphavirus Virulence Determinants [PDF]
Pathogens, 2021 Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel +1 more
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Alphavirus-Based Vaccines [PDF]
Viruses, 2014 Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
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Plasmid DNA-based Alphavirus Vaccines [PDF]
Vaccines, 2019 Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
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Salmonid alphavirus (SAV) [PDF]
Journal of Veterinary Research, 2018 Salmonid alphavirus (SAV), genus Alphavirus, family Togaviridae, is a single-stranded RNA virus affecting Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). It is known to be responsible for pancreas disease (PD) and sleeping disease (
Deperasińska Izabela +2 more
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Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. [PDF]
PLoS Pathogens, 2015 The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo +12 more
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Synthesis of Alphavirus-Specified RNA [PDF]
Journal of Virology, 1978 UV irradiation of chicken fibroblasts infected with Semliki Forest or Sindbis virus has been used to investigate the mechanism of synthesis of 42S and 26S RNA, the major plus-strand virus-specified RNAs formed during the multiplication of standard virus particles.
Henry Brzeski, S. I. T. Kennedy
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Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1. [PDF]
Adv Sci (Weinh)Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Zhang Y +10 more
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Imaging the Alphavirus Exit Pathway [PDF]
Journal of Virology, 2014 ABSTRACT Alphaviruses are small enveloped RNA viruses with highly organized structures that exclude host cell proteins. They contain an internal nucleocapsid and an external lattice of the viral E2 and E1 transmembrane proteins. Alphaviruses bud from the plasma membrane (PM), but the process and dynamics of alphavirus assembly and budding are
María Guadalupe Martínez +4 more
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Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
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