Results 51 to 60 of about 15,250 (221)

hnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA [PDF]

, 2010
Background Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus ...
Hongxin Gui, Chi-Wei Lu, Sandra Adams, Victor Stollar, Mei-Ling Li   +4 more
core   +2 more sources

In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases.

PLoS ONE, 2021
The potential outcome of flavivirus and alphavirus co-infections is worrisome due to the development of severe diseases. Hundreds of millions of people worldwide live under the risk of infections caused by viruses like chikungunya virus (CHIKV, genus ...
Raphael J Eberle, Danilo S Olivier, Carolina C Pacca, Clarita M S Avilla, Mauricio L Nogueira, Marcos S Amaral, Dieter Willbold, Raghuvir K Arni, Monika A Coronado   +8 more
doaj   +1 more source

Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases

Microorganisms, 2022
Several neurotropic viruses are members of the flavivirus and alphavirus families. Infections caused by these viruses may cause long-term neurological sequelae in humans.
Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Carolina C. Pacca, Mauricio L. Nogueira, Raghuvir K. Arni, Dieter Willbold, Monika A. Coronado   +7 more
doaj   +1 more source

Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions [PDF]

, 1985
We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome.
Franke, Christine A., Hruby, Dennis E., Rice, Charles M., Strauss, James H.   +3 more
core  

Advances in dissecting mosquito innate immune responses to arbovirus infection [PDF]

, 2009
Arthropod-borne viruses – arboviruses – are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control ...
A. A. Nash, A. Kohl, Aliyari, Alphey, Barillas-Mury, Barillas-Mury, Best, Blair, Blitvich, Borucki, Bowers, Bowie, Campbell, Campbell, Caudy, Caudy, Christophides, Christophides, Cirimotich, Condreay, Deddouche, Deo, Ding, Dostert, Ferrandon, Fragkoudis, G. Attarzadeh-Yazdi, Galiana-Arnoux, Garcia, Garcia, Garmashova, Geiss, Gillies, Gillies, Girard, GIRARD, Gordon, Gordon, Gould, Halstead, Hedges, Hedges, Hirai, Holt, J. K. Fazakerley, Jiravanichpaisal, Kang, Karpf, Kemp, Kuno, Kyle, Landeg, Lemaitre, Li, Li, Lin, McMeniman, Medeiros, Mims, Molnar, Newton, Obbard, Olson, Osta, Papanayotou, Parikh, Powers, R. Fragkoudis, Randall, Robalino, Robalino, Sabatier, Saleh, Sanchez-Vargas, Sanchez-Vargas, Sanders, Scholthof, Shelly, Sim, Sim, Soldan, Tortosa, Travanty, van Rij, van Rij, Voinnet, Wang, Waterhouse, Weaver, Weaver, Weaver, Weaver, Whitten, Xi, Xie, Yoneyama, Zambon, Zelivianski   +97 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.

PLoS Neglected Tropical Diseases, 2017
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud   +9 more
doaj   +1 more source

High costs of infection: Alphavirus infection reduces digestive function and bone and feather growth in nestling house sparrows (Passer domesticus). [PDF]

PLoS ONE, 2018
Increasingly, ecoimmunology studies aim to use relevant pathogen exposure to examine the impacts of infection on physiological processes in wild animals.
Carol A Fassbinder-Orth, Tess L Killpack, Dylan S Goto, Ellecia L Rainwater, Valerie I Shearn-Bochsler   +4 more
doaj   +1 more source

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source