Results 61 to 70 of about 9,810 (173)

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection

Journal of Virology, 2000
ABSTRACT The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420.
T, Ahola, P, Kujala, M, Tuittila, T, Blom, P, Laakkonen, A, Hinkkanen, P, Auvinen   +6 more
openaire   +3 more sources

Characterization of an In Vitro Model of Alphavirus Infection of Immature and Mature Neurons [PDF]

Journal of Virology, 2005
ABSTRACT Terminally differentiated, mature neurons are essential cells that are not easily regenerated. Neurotropic viruses, such as Sindbis virus (SV), cause encephalomyelitis through their ability to replicate in neurons. SV causes the death of immature neurons, while mature neurons can often survive infection.
Patty S, Vernon, Diane E, Griffin
openaire   +2 more sources

Post‐Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta‐Analysis of Associated Factors

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Post‐dengue fatigue syndrome is a debilitating long‐term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post‐dengue depression complicate differentiation.
Anna Condé, Olivier Maillard, Chaturaka Rodrigo, Antoine Bertolotti, Carolina X. Sandler, Andrew R. Lloyd, Patrick Gérardin   +6 more
wiley   +1 more source

Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX₃CR1⁺ Macrophages in Tissue Repair

mBio, 2020
Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks.
Ali Zaid, Kothila Tharmarajah, Helen Mostafavi, Joseph R. Freitas, Kuo-Ching Sheng, Suan-Sin Foo, Weiqiang Chen, Jelena Vider, Xiang Liu, Nicholas P. West, Lara J. Herrero, Adam Taylor, Laura K. Mackay, Daniel R. Getts, Nicholas J. C. King, Suresh Mahalingam   +15 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight [PDF]

Veterinary Research, 2016
Salmonid alphavirus (SAV) is an enveloped, single-stranded, positive sense RNA virus belonging to the family Togaviridae. It causes economically devastating disease in cultured salmonids. The characteristic features of SAV infection include severe histopathological changes in the heart, pancreas and skeletal muscles of diseased fish.
Herath, Tharangani, Ferguson, Hugh, Weidmann, Manfred, Bron, James, Thompson, Kim D, Adams, Alexandra, Muir, Katherine, Richards, Randolph   +7 more
openaire   +5 more sources

Chikungunya Vaccine Candidates: Current Landscape and Future Prospects

Drug Design, Development and Therapy, 2022
Christin Schmidt, Barbara S Schnierle Paul-Ehrlich-Institut, Department of Virology, Section AIDS and Newly Emerging Pathogens, Langen, GermanyCorrespondence: Barbara S Schnierle, Paul-Ehrlich-Institut, Department of Virology, Section AIDS and newly ...
Schmidt C, Schnierle BS
doaj  

Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil?

Brazilian Journal of Infectious Diseases, 2017
Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade ...
Danillo Lucas Alves Esposito, Benedito Antonio Lopes da Fonseca   +1 more
doaj   +1 more source

Vector‐borne diseases‐knowledge maps

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This scientific report provides a structured overview of the main characteristics of 25 selected vector‐borne diseases (VBDs) of potential relevance for the EU, including 12 diseases listed under the Animal Health Law (AHL) and 13 non‐listed diseases.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source