Translational Control of Alphavirus–Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response [PDF]
VirusesAlphaviruses can replicate in arthropods and in many vertebrate species including humankind, but only in vertebrate cells do infections with these viruses result in a strong inhibition of host translation and transcription.
Iván Ventoso +3 more
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Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections [PDF]
Pathogens, 2021 Ivan Akhrymuk +2 more
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Venezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity [PDF]
npj VirusesVenezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus that causes severe neuroinflammation and fatal infections in some people. Numerous outbreaks of VEEV have been reported in Latin America in the past century. Though mosquito-borne,
Kenneth C. Elliott +2 more
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Acute Flavivirus and Alphavirus Infections among Children in Two Different Areas of Kenya, 2015 [PDF]
American Journal of Tropical Medicine and Hygiene, 2019 Francis Mutuku +2 more
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DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy
Cell ReportsSummary: Alphaviruses are mosquito-transmitted viruses that cause severe zoonotic diseases. Their envelope glycoproteins, E1 and E2, undergo cysteine acylation, a process critical for virus infection but previously undefined mechanistically.
Xiaoling Li +11 more
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The Role of the Deubiquitylase MYSM1 During Alphavirus Infection [PDF]
, 2018 The Role of the Deubiquitylase MYSM1 During Alphavirus Infection Amer Nubgan The members of the genus Alphavirus are positive-sense RNA viruses and it is one of two within the family Togaviridae.
Nubgan, AS
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Molecular and cellular evidence of natural Venezuelan equine encephalitis virus infection in frugivorous bats in Colombia [PDF]
Veterinary World, 2020 Background and Aim: Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes encephalitis with a high impact on public health in Latin America.
Camilo Guzmán +6 more
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Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
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Entry receptors — the gateway to alphavirus infection
Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past four years, aided by CRISPR/Cas9-based genetic screening approaches, intensive research efforts ...
Ofer Zimmerman +4 more
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The Regulation of Translation in Alphavirus-Infected Cells [PDF]
Viruses, 2018 Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco +2 more
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