Results 31 to 40 of about 819,223 (194)

Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.

PLoS Pathogens, 2015
The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo, Weiqiang Chen, Adam Taylor, Kuo-Ching Sheng, Xing Yu, Terk-Shin Teng, Patrick C Reading, Helen Blanchard, Cecilia Garlanda, Alberto Mantovani, Lisa F P Ng, Lara J Herrero, Suresh Mahalingam   +12 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006

Emerging Infectious Diseases, 2010
Mother-to-child transmission of chikungunya virus was reported during the 2005–2006 outbreak on Réunion Island, France. To determine the effects of this virus on pregnancy outcomes, we conducted a study of pregnant women in Réunion in 2006.
Xavier Fritel, Olivier Rollot, Patrick Gérardin, Bernard-Alex Gaüzère, Jacques Bideault, Louis Lagarde, Barbara Dhuime, Eric Orvain, Fabrice Cuillier, Duksha Ramful, Sylvain Sampériz, Marie-Christine Jaffar-Bandjee, Alain Michault, Liliane Cotte, Monique Kaminski, Alain Fourmaintraux   +15 more
doaj   +1 more source

Identification of 2,4-Diaminoquinazoline Derivative as a Potential Small-Molecule Inhibitor against Chikungunya and Ross River Viruses

Viruses, 2023
Alphaviruses are serious zoonotic threats responsible for significant morbidity, causing arthritis or encephalitis. So far, no licensed drugs or vaccines are available to combat alphaviral infections.
Amrita Saha, Badri Narayan Acharya, Manmohan Parida, Nandita Saxena, Jaya Rajaiya, Paban Kumar Dash   +5 more
doaj   +1 more source

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Cells, 2020
Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals.
Lucie Cappuccio, Carine Maisse
doaj   +1 more source

Imported Arbovirus Infections in Canada 1974-89

Canadian Journal of Infectious Diseases, 1991
From 1974 to 1989, sera from symptomatic patients with histories of recent travel outside Canada were tested for antibodies to several arboviruses, principally of the alphavirus and flavivirus families.
Harvey Artsob, Leslie Spence
doaj   +1 more source

The Host Non-Coding RNA Response to Alphavirus Infection

Viruses, 2023
Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
openaire   +3 more sources

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Detection of two alphaviruses: Middelburg virus and Sindbis virus from enzootic amplification cycles in southwestern Uganda

Frontiers in Microbiology
Our knowledge of alphavirus genetic diversity is mainly based on viruses isolated from anthropophilic mosquito species, humans, and livestock during outbreaks.
Selina Laura Graff, Georg Joachim Eibner, James Robert Ochieng, Terry C. Jones, Terry C. Jones, Terry C. Jones, Anthony Mutebi Nsubuga, Julius Julian Lutwama, Innocent Bidason Rwego, Sandra Junglen   +9 more
doaj   +1 more source

Alphavirus-Induced Membrane Rearrangements during Replication, Assembly, and Budding

Pathogens, 2021
Alphaviruses are arthropod-borne viruses mainly transmitted by hematophagous insects that cause moderate to fatal disease in humans and other animals. Currently, there are no approved vaccines or antivirals to mitigate alphavirus infections.
Zeinab Elmasri, Benjamin L. Nasal, Joyce Jose   +2 more
doaj   +1 more source