Results 31 to 40 of about 15,250 (221)

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source

Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]

, 2014
Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle, Kohl, Alain, Rainey, Stephanie M., Shah, Pranav   +3 more
core   +1 more source

Salmonid alphavirus (SAV)

Journal of Veterinary Research, 2018
Salmonid alphavirus (SAV), genus Alphavirus, family Togaviridae, is a single-stranded RNA virus affecting Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). It is known to be responsible for pancreas disease (PD) and sleeping disease (
Deperasińska Izabela, Schulz Patrycja, Siwicki Andrzej K.   +2 more
doaj   +1 more source

Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly

mBio, 2020
Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan, Rebecca S. Brown, Margaret Kielian   +2 more
doaj   +1 more source

Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

Molecules, 2022
The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen, Emmanuelle Girard-Valenciennes, Axelle Septembre-Malaterre, Philippe Gasque, Pascale Guiraud, Jimmy Sélambarom   +5 more
doaj   +1 more source

Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells [PDF]

, 2013
The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes. Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described
Donald, Claire L., Fazakerley, John K., Fragkoudis, Rennos, Human, Stacey, Kohl, Alain, McFarlane, Melanie, Schnettler, Esther, Siu, Ricky W. C., Watson, Mick   +8 more
core   +3 more sources

Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation [PDF]

, 1987
International audienceThe Dark Energy Camera has captured a large set of images as part of Science Verification (SV) for the Dark Energy Survey (DES). The SV footprint covers a large portion of the outer Large Magellanic Cloud (LMC), providing photometry
Abbott, T. M. C., Allam, S. S., Annis, J., Balbinot, Eduardo, Benoit-Levy, A., Bernstein, J. P., Bernstein, R. A., Bertin, E., Brooks, D., Buckley-Geer, E., Cunha, C. E., Da Costa, L. N., DePoy, D. L., Desai, S., Diehl, H. T., Doel, P., Drlica-Wagner, A., Estrada, J., Evrard, A. E., Finley, D. A., Flaugher, B., Frieman, J. A., Girardi, L., Gruen, D., Gruendl, R. A., Honscheid, K., James, D., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., March, M., Marshall, J. L., Miller, C., Miquel, R., Neto, A. Fausti, Ogando, R., Peoples, J., Pieres, A., Plazas, A., Rosell, A. Carnero, Santiago, B. X., Scarpine, V., Schubnell, M., Sevilla-Noarbe, I., Smith, R. C., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., Wechsler, R., Yanny, B., Zuntz, J.   +54 more
core   +4 more sources

Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]

Journal of Virology, 2015
ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
K J, Sokoloski, K C, Haist, T E, Morrison, S, Mukhopadhyay, R W, Hardy   +4 more
openaire   +2 more sources

Identification of 2,4-Diaminoquinazoline Derivative as a Potential Small-Molecule Inhibitor against Chikungunya and Ross River Viruses

Viruses, 2023
Alphaviruses are serious zoonotic threats responsible for significant morbidity, causing arthritis or encephalitis. So far, no licensed drugs or vaccines are available to combat alphaviral infections.
Amrita Saha, Badri Narayan Acharya, Manmohan Parida, Nandita Saxena, Jaya Rajaiya, Paban Kumar Dash   +5 more
doaj   +1 more source

Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors [PDF]

Journal of Visualized Experiments, 2010
Alphavirus transducing systems (ATSs) are important tools for expressing genes of interest (GOI) during infection. ATSs are derived from cDNA clones of mosquito-borne RNA viruses (genus Alphavirus; family Togaviridae). The Alphavirus genus contains about 30 different mosquito-borne virus species.
Aaron, Phillips, Eric, Mossel, Irma, Sanchez-Vargas, Brian, Foy, Ken, Olson   +4 more
openaire   +2 more sources