Results 21 to 30 of about 819,223 (194)
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
doaj +1 more source
Entry receptors — the gateway to alphavirus infection
Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past four years, aided by CRISPR/Cas9-based genetic screening approaches, intensive research efforts ...
Ofer Zimmerman +4 more
openaire +4 more sources
The Regulation of Translation in Alphavirus-Infected Cells [PDF]
Viruses, 2018 Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco +2 more
openaire +4 more sources
Eugenol-Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights. [PDF]
J Med VirolABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Reis ACC +9 more
europepmc +2 more sources
Innate immune control of alphavirus infection [PDF]
Current Opinion in Virology, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Kathryn S, Carpentier +1 more
openaire +2 more sources
Arthritogenic Alphavirus Capsid Protein
, 2021 In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Taylor, Adam +3 more
core +1 more source
Effect of alphavirus infection on mouse embryos [PDF]
Infection and Immunity, 1982 Seven strains and mutants of the alphaviruses, Semliki Forest virus and Sindbis virus, differed in their lethality for mouse embryos and their mothers. The A7 strain and the neurovirulence mutant M103 of Semliki Forest virus were selected for detailed comparison. A7 produced 100% lethality of mouse embryos but was avirulent for their mothers.
Atkins, G J, Carter, J, Sheahan, B J
openaire +2 more sources
Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]
, 2007 Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K +11 more
core +1 more source
Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines
Molecules, 2022 The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen +5 more
doaj +1 more source
Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall [PDF]
Journal of Virology, 2021 Abstract The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a ...
Lana Langendries +7 more
openaire +2 more sources