Results 11 to 20 of about 9,810 (173)

Venezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity [PDF]

npj Viruses
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus that causes severe neuroinflammation and fatal infections in some people. Numerous outbreaks of VEEV have been reported in Latin America in the past century. Though mosquito-borne,
Kenneth C. Elliott, David Saunders, Joseph J. Mattapallil   +2 more
doaj   +2 more sources

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Molecular and cellular evidence of natural Venezuelan equine encephalitis virus infection in frugivorous bats in Colombia [PDF]

Veterinary World, 2020
Background and Aim: Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes encephalitis with a high impact on public health in Latin America.
Camilo Guzmán, Alfonso Calderón, Teresa Oviedo, Salim Mattar, José Castañeda, Virginia Rodriguez, Luiz Tadeu Moraes Figueiredo   +6 more
doaj   +1 more source

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]

PLoS Pathogens, 2012
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani, Michael R Wiley, Marta G Murreddu, Zach N Adelman, Kevin M Myles   +4 more
doaj   +1 more source

Entry receptors — the gateway to alphavirus infection

Journal of Clinical Investigation, 2023
Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past four years, aided by CRISPR/Cas9-based genetic screening approaches, intensive research efforts ...
Ofer Zimmerman, Autumn C. Holmes, Natasha M. Kafai, Lucas J. Adams, Michael S. Diamond   +4 more
openaire   +4 more sources

The Regulation of Translation in Alphavirus-Infected Cells [PDF]

Viruses, 2018
Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco, Miguel Sanz, Esther González-Almela   +2 more
openaire   +4 more sources

Innate immune control of alphavirus infection [PDF]

Current Opinion in Virology, 2018
Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Kathryn S, Carpentier, Thomas E, Morrison   +1 more
openaire   +2 more sources

Effect of alphavirus infection on mouse embryos [PDF]

Infection and Immunity, 1982
Seven strains and mutants of the alphaviruses, Semliki Forest virus and Sindbis virus, differed in their lethality for mouse embryos and their mothers. The A7 strain and the neurovirulence mutant M103 of Semliki Forest virus were selected for detailed comparison. A7 produced 100% lethality of mouse embryos but was avirulent for their mothers.
Atkins, G J, Carter, J, Sheahan, B J
openaire   +2 more sources

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +1 more source

Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis [PDF]

Journal of Virology, 2018
ABSTRACT Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited. Mosquito vectors such as Aedes and Culex
Siew-Wai, Fong, R Manjunatha, Kini, Lisa F P, Ng   +2 more
openaire   +2 more sources