Results 21 to 30 of about 12,699 (245)

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +2 more sources

Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents

Viruses
Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world.
Kenneth Lundstrom
doaj   +2 more sources

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ^®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow   +16 more
doaj   +2 more sources

Alphaviruses in Immunotherapy and Anticancer Therapy

Biomedicines, 2022
Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
K. Lundstrom
semanticscholar   +2 more sources

The genetics of alphaviruses

Future Virology, 2011
Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks ...
Suan Sin Foo, Mahalingam, Suresh, Chen, Weiqiang, Weiqiang Chen, Lara Herrero, Herrero, Lara, Foo, Suan Sin, Jayasuryan Narayan, Jayaram Bettadapura, Lalit Dar, Shobha Broor, Suresh Mahalingam, Bettadapura, Jayaram, Narayan, Jayasuryan, Dar, Lalit, Broor, Shobha   +15 more
core   +3 more sources

Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses

PLoS Pathogens
Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses and piglets; it also poses a potential threat to humans.
Zhiwen Jiang, A. Merits, Ying Qin, Gang Xing, Le-Tian Zhang, Jie Chen, Ning-Ning Wang, Margus Varjak, Xiao-Feng Zhai, Dongyan Li, Wan-Jie Song, Shuo Su   +11 more
semanticscholar   +2 more sources

A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans

Science Translational Medicine, 2023
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle–adjuvanted vaccine (PXVX0317) from samples obtained ...
S. Raju, L. Adams, J. T. Earnest, Kelly L. Warfield, L. Vang, J. Crowe, D. Fremont, M. Diamond   +7 more
semanticscholar   +1 more source

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein

PLoS Neglected Tropical Diseases, 2023
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
John M. Powers, Zoe L. Lyski, W. Weber, Michael C. Denton, Magdalene M. Streblow, Adam T. Mayo, Nicole N. Haese, Chad D. Nix, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, W. Messer, Daniel N. Streblow   +12 more
semanticscholar   +1 more source

VLDLR and ApoER2 are receptors for multiple alphaviruses

Nature, 2021
Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect vectors separated by hundreds of millions of years of evolutionary history.
L. Clark, S. Clark, Chieyu Lin, Jianying Liu, A. Coscia, K. Nabel, Pan Yang, Dylan V. Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, K. Plante, Asim A. Ahmed, F. Catteruccia, Tracy L. Young-Pearse, I. Chiu, P. Llopis, S. Weaver, J. Abraham   +18 more
semanticscholar   +1 more source

The many ways in which alphaviruses bind to cells

Trends in immunology, 2023
Only a subset of viruses can productively infect many different host species. Some arthropod-transmitted viruses, such as alphaviruses, can infect invertebrate and vertebrate species including insects, reptiles, birds, and mammals. This broad tropism may
S. Raju, L. Adams, Michael S. Diamond
semanticscholar   +1 more source