Results 41 to 50 of about 9,502 (198)
Antiviral drug discovery against arthritogenic alphaviruses: Tools and molecular targets [PDF]
, 2020 Alphaviruses are (mainly) arthropod-borne viruses that belong to the family of the Togaviridae. Based on the disease they cause, alphaviruses are divided into an arthritogenic and an encephalitic group.
Abdelnabi, Rana +3 more
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Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins
Pathogens, 2023 Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Sofia E. Delgado-Rodriguez +2 more
doaj +1 more source
Global emergence of Alphaviruses that cause arthritis in humans [PDF]
, 2015 Arthropod-borne viruses (arboviruses) may cause severe emerging and re-emerging infectious diseases, which pose a significant threat to human and animal health in the world today.
Otieno, Viola +13 more
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Alphaviruses in Cancer Therapy
Frontiers in Molecular Biosciences, 2022 Alphaviruses have been engineered as expression vectors for different strategies of cancer therapy including immunotherapy and cancer vaccine development. Administration of recombinant virus particles, RNA replicons and plasmid DNA-based replicons provide great flexibility for alphavirus applications. Immunization and delivery studies have demonstrated
openaire +3 more sources
Alphaviruses in Latin America and the Introduction of Chikungunya Virus [PDF]
, 2017 Alphaviruses are enveloped, single-stranded, plus-strand RNA viruses belonging to the Togaviridae family. These are zoonotics and arthropod-borne viruses (mainly mosquitoes) that are distributed nearly worldwide.
Jean-Paul Carrera +8 more
core +1 more source
Packaging signals in alphaviruses [PDF]
Journal of Virology, 1997 Alphaviruses synthesize large amounts of both genomic and subgenomic RNA in infected cells, but usually only the genomic RNA is packaged. This implies the existence of an encapsidation or packaging signal which would be responsible for selectivity. Previously, we had identified a region of the Sindbis virus genome that interacts specifically with the ...
E, Frolova, I, Frolov, S, Schlesinger
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Direct broad-range detection of alphaviruses in mosquito extracts [PDF]
, 2007 Members of the genus Alphavirus are a diverse group of principally mosquito-borne RNA viruses. There are at least 29 species and many more subtypes of alphaviruses and some are considered potential bioweapons.
Rudnick, Karl +19 more
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Perspectives for applying Alphaviruses in antitumor therapy
Инфекция и иммунитет, 2023 Oncolytic viral therapy is a promising approach for treating tumors. Oncolytic viruses can directly lyse tumor cells and indirectly activate antitumor immunity.
Alina S. Nazarenko +5 more
doaj +1 more source
Replication of the genome of alphaviruses [PDF]
Journal of Cell Science, 1987 ABSTRACT The genome of Semliki Forest virus (SFV) is 11 442 nucleotides with a 5′ cap-structure and a 3′ poly(A) tail of about 100 residues. The genome of the closely related Sindbis virus (SIN) is slightly longer (11 703 nucleotides). The parental RNA is first translated from the 5′ two thirds to yield; nsPl, nsP2, nsP3 and nsP4, which ...
L, Kääriäinen +3 more
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Chikungunya Virus and (Re-) Emerging Alphaviruses [PDF]
, 2019 Alphaviruses belong to a family of positive sense, single-stranded RNA viruses that are transmitted mainly by mosquitoes through a blood meal and cause arthritis and/or encephalitis in humans and animals [...
Penghua Wang, Rong Zhang
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