Results 41 to 50 of about 12,699 (245)

Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus Biology

Viruses, 2021
RNA viruses cause a wide range of human diseases that are associated with high mortality and morbidity. In the past decades, the rise of genetic-based screening methods and high-throughput sequencing approaches allowed the uncovering of unique and ...
Yogy Simanjuntak, Kira Schamoni-Kast, Alice Grün, Charlotte Uetrecht, Pietro Scaturro   +4 more
doaj   +1 more source

Antiviral drug discovery against arthritogenic alphaviruses: Tools and molecular targets [PDF]

, 2020
Alphaviruses are (mainly) arthropod-borne viruses that belong to the family of the Togaviridae. Based on the disease they cause, alphaviruses are divided into an arthritogenic and an encephalitic group.
Abdelnabi, Rana, Neyts, Johan, Delang, Leen, Jacobs, Sofie   +3 more
core   +1 more source

TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids. [PDF]

Emerg Microbes Infect
Human T-cell immunoglobulin and mucin domain 1 (TIM-1) facilitates infection of re-emerging viruses, including alphaviruses, through its phosphatidylserine (PS) binding domain.
Yoo JE, de Bruin ACM, Reßin H, Paužuolis M, Liu L, Moosmann A, Becker M, Lasswitz L, Groß R, Gerold G.   +9 more
europepmc   +2 more sources

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Viruses, 2021
Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations ...
Ivanildo P. Sousa, Flavia B. dos Santos, Vanessa S. de Paula, Tuane C.R.G. Vieira, Helver G. Dias, Caroline A. Barros, Edson E. da Silva   +6 more
doaj   +1 more source

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

Pathogens, 2022
Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines.
A. Leung, D. Griffin, J. Bosch, A. Fehr
semanticscholar   +1 more source

A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses

Viruses, 2019
Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of the Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash and incapacitating poly-arthralgia ...
Yessica Y. Llamas-González, Dalkiria Campos, Juan M. Pascale, Juan Arbiza, José González-Santamaría   +4 more
doaj   +1 more source

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors

Microorganisms, 2021
Despite the emerging threat of the Mayaro virus (MAYV) in Central and South-America, there are no licensed antivirals or vaccines available for this neglected mosquito-borne virus.
Lana Langendries, Rana Abdelnabi, Johan Neyts, Leen Delang   +3 more
doaj   +1 more source

The Life Cycle of the Alphaviruses: From an Antiviral Perspective

Antiviral Research, 2022
The alphaviruses are a widely distributed group of positive-sense, single stranded, RNA viruses. These viruses are largely arthropod-borne and can be found on all populated continents.
Andrew M. Skidmore, Steven B. Bradfute
semanticscholar   +1 more source

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

Nature Communications, 2021
Mayaro virus (MAYV) is an emerging arbovirus of the Americas that may cause a debilitating arthritogenic disease. The biology of MAYV is not fully understood and largely inferred from related arthritogenic alphaviruses.
H. V. Ribeiro-Filho, L. D. Coimbra, Alexandre Cassago, R. Rocha, João Victor da Silva Guerra, R. de Felício, Carolina Moretto Carnieli, Luiza Leme, A. C. Padilha, A. P. Paes Leme, D. B. Trivella, R. Portugal, P. Lopes-de-Oliveira, R. Marques   +13 more
semanticscholar   +1 more source

Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins

Pathogens, 2023
Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Sofia E. Delgado-Rodriguez, Andrew P. Ryan, Matthew D. Daugherty   +2 more
doaj   +1 more source