Results 31 to 40 of about 12,699 (245)

Establishment of an Alphavirus-Specific Neutralization Assay to Distinguish Infections with Different Members of the Semliki Forest complex

Viruses, 2019
Background: Alphaviruses are transmitted by arthropod vectors and can be found worldwide. Alphaviruses of the Semliki Forest complex such as chikungunya virus (CHIKV), Mayaro virus (MAYV) or Ross River virus (RRV) cause acute febrile illness and long ...
Lisa Henss, Constanze Yue, Joshua Kandler, Helen M. Faddy, Graham Simmons, Marcus Panning, Lia Laura Lewis-Ximenez, Sally A. Baylis, Barbara S. Schnierle   +8 more
doaj   +1 more source

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Cells, 2020
Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals.
Lucie Cappuccio, Carine Maisse
doaj   +1 more source

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses

Viruses, 2023
New World alphaviruses including Venezuelan Equine Encephalitis Virus (VEEV) and Eastern Equine Encephalitis Virus (EEEV) are mosquito-transmitted viruses that cause disease in humans and equines.
Niloufar A. Boghdeh, B. McGraw, Michael D. Barrera, Carol Anderson, Haseebullah Baha, Kenneth H. Risner, I. V. Ogungbe, Farhang Alem, Aarthi Narayanan   +8 more
semanticscholar   +1 more source

Recombinant Virus Quantification Using Single-Cell Droplet Digital PCR: A Method for Infectious Titer Quantification

Viruses, 2023
The quantification of viruses is necessary for both research and clinical applications. The methods available for RNA virus quantification possess several drawbacks, including sensitivity to inhibitors and the necessity of a standard curve generation ...
Ksenija Korotkaja, Anna Zajakina
doaj   +1 more source

Role of macrophages in the onset, maintenance, or control of arthritis caused by alphaviruses

Experimental biology and medicine, 2023
Arthritogenic alphaviruses are mosquito-borne viruses that cause a debilitating rheumatic disease characterized by fever, headache, rash, myalgia, and polyarthralgia with the potential to evolve into a severe and very prolonged illness.
Matheus O. Atella, A. S. Carvalho, A. D. Da Poian   +2 more
semanticscholar   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Zoonotic Alphaviruses in Fatal and Neurologic Infections in Wildlife and Nonequine Domestic Animals, South Africa [PDF]

, 2020
Alphaviruses from Africa, such as Middelburg virus (MIDV), and Sindbis virus (SINV), were detected in horses with neurologic disease in South Africa, but their host ranges remain unknown. We investigated the contribution of alphaviruses to neurologic
Elizabeth Botha, Marietjie Venter, Bjorn Reininghaus, Fourie, Isabel, Johan Steyl, Jumari Steyn, Voula Stivaktas, Isabel Fourie, Reininghaus, V., Steyl, Johan Christian Abraham, June Williams, Van Niekerk, Stephanie, Botha, Elizabeth, Venter, Marietjie, Steyn, Jumari, Williams, June Heather, Stivaktas, Voula, Stefanie van Niekerk   +17 more
core   +1 more source

Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses.

Journal of Infectious Diseases, 2023
The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human pathogens with the potential to spread to near pandemic proportions. Most of these are zoonotic, with spillover infections of humans and domestic animals, but a few such as ...
A. Powers, Lauren E. Williamson, Robert H. Carnahan, James E. Crowe, Jennifer L. Hyde, Colleen B Jonsson, Farooq Nasar, S. Weaver   +7 more
semanticscholar   +1 more source

A high throughput antiviral screening platform for alphaviruses based on Semliki Forest virus expressing eGFP reporter gene

Virologica Sinica, 2023
Alphaviruses, which contain a variety of mosquito-borne pathogens, are important pathogens of emerging/re-emerging infectious diseases and potential biological weapons.
Yu-Jia Shi, Jia-Qi Li, Hong-Qing Zhang, Cheng-Lin Deng, Qingge Zhu, Bo Zhang, Xiao-Dan Li   +6 more
semanticscholar   +1 more source

Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses

Journal of Virology, 2022
Due to decades of inadequate monitoring and lack of vaccines and specific treatment, a large number of people have been infected with alphaviruses. GETV is a re-emerging alphavirus that has the potential to infect humans.
Ningning Wang, Xiao-Feng Zhai, Xiaoli Li, Yu Wang, Wanting He, Zhiwen Jiang, M. Veit, Shuo Su   +7 more
semanticscholar   +1 more source