Results 31 to 40 of about 13,308 (216)
Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins
Pathogens, 2023 Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Sofia E. Delgado-Rodriguez +2 more
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Packaging signals in alphaviruses [PDF]
Journal of Virology, 1997 Alphaviruses synthesize large amounts of both genomic and subgenomic RNA in infected cells, but usually only the genomic RNA is packaged. This implies the existence of an encapsidation or packaging signal which would be responsible for selectivity. Previously, we had identified a region of the Sindbis virus genome that interacts specifically with the ...
E, Frolova, I, Frolov, S, Schlesinger
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Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. [PDF]
, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Daugherty, Matthew D +3 more
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To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Perspectives for applying Alphaviruses in antitumor therapy
Инфекция и иммунитет, 2023 Oncolytic viral therapy is a promising approach for treating tumors. Oncolytic viruses can directly lyse tumor cells and indirectly activate antitumor immunity.
Alina S. Nazarenko +5 more
doaj +1 more source
Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]
, 2015 Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K. +10 more
core +1 more source
Wild birds as carriers of antimicrobial-resistant and ESBL-producing Enterobacteriaceae [PDF]
, 2016 open6noopenDotto, G.; Menandro, M.L.; Mondin, A.; Martini, M.; Tonellato, F.R.; Pasotto, D.Dotto, Giorgia; Menandro, MARIA LUISA; Mondin, Alessandra; Martini, Marco; Tonellato, F.
Dotto, Giorgia +5 more
core +1 more source
Replication of the genome of alphaviruses [PDF]
Journal of Cell Science, 1987 ABSTRACT The genome of Semliki Forest virus (SFV) is 11 442 nucleotides with a 5′ cap-structure and a 3′ poly(A) tail of about 100 residues. The genome of the closely related Sindbis virus (SIN) is slightly longer (11 703 nucleotides). The parental RNA is first translated from the 5′ two thirds to yield; nsPl, nsP2, nsP3 and nsP4, which ...
L, Kääriäinen +3 more
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Viruses, 2014 Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
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Alphaviruses in Cancer Therapy
Frontiers in Molecular Biosciences, 2022 Alphaviruses have been engineered as expression vectors for different strategies of cancer therapy including immunotherapy and cancer vaccine development. Administration of recombinant virus particles, RNA replicons and plasmid DNA-based replicons provide great flexibility for alphavirus applications. Immunization and delivery studies have demonstrated
openaire +3 more sources