Results 31 to 40 of about 9,502 (198)

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Cells, 2020
Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals.
Lucie Cappuccio, Carine Maisse
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
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Recombinant Virus Quantification Using Single-Cell Droplet Digital PCR: A Method for Infectious Titer Quantification

Viruses, 2023
The quantification of viruses is necessary for both research and clinical applications. The methods available for RNA virus quantification possess several drawbacks, including sensitivity to inhibitors and the necessity of a standard curve generation ...
Ksenija Korotkaja, Anna Zajakina
doaj   +1 more source

Animal Models of Alphavirus-induced Inflammatory Disease [PDF]

, 2016
Animal models that reflect key aspects of human disease are invaluable tools for understanding the mechanisms of disease pathogenesis and development of treatment strategies.
Taylor, Adam, Pierre Roques, Suresh Mahalingam, Mahalingam, Suresh, Adam Taylor, Lidbury, Brett A, Lidbury, Brett A., Herrero, Lara J, Roques, Pierre, Lara J. Herrero, Brett A. Lidbury, Herrero, Lara   +11 more
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Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus Biology

Viruses, 2021
RNA viruses cause a wide range of human diseases that are associated with high mortality and morbidity. In the past decades, the rise of genetic-based screening methods and high-throughput sequencing approaches allowed the uncovering of unique and ...
Yogy Simanjuntak, Kira Schamoni-Kast, Alice Grün, Charlotte Uetrecht, Pietro Scaturro   +4 more
doaj   +1 more source

A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses

Viruses, 2019
Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of the Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash and incapacitating poly-arthralgia ...
Yessica Y. Llamas-González, Dalkiria Campos, Juan M. Pascale, Juan Arbiza, José González-Santamaría   +4 more
doaj   +1 more source

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Viruses, 2021
Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations ...
Ivanildo P. Sousa, Flavia B. dos Santos, Vanessa S. de Paula, Tuane C.R.G. Vieira, Helver G. Dias, Caroline A. Barros, Edson E. da Silva   +6 more
doaj   +1 more source

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors

Microorganisms, 2021
Despite the emerging threat of the Mayaro virus (MAYV) in Central and South-America, there are no licensed antivirals or vaccines available for this neglected mosquito-borne virus.
Lana Langendries, Rana Abdelnabi, Johan Neyts, Leen Delang   +3 more
doaj   +1 more source

Arthrogenic Alphaviruses and Inflammatory Myopathies [PDF]

, 2011
There is increasing evidence to suggest that viruses have aetiological roles in the idiopathic inflammatory myopathies. Arthrogenic alphaviruses (such as chikungunya virus, Ross River virus and sindbis virus) are known to cause outbreaks of polyarthritis
Suresh Mahalingam, Mahalingam, Suresh, Lara Herrero, Herrero, Lara   +3 more
core   +1 more source

Alphaviruses and their role in elucidating antiviral responses in mosquitoes [PDF]

, 2016
The interaction between mosquito vectors and arthropod-borne viruses (arboviruses) such as alphaviruses of the Togaviridae family has long been of central interest to virologists.
Kohl, Alain, Melanie McFarlane, Alain Kohl, McFarlane, Melanie   +3 more
core   +1 more source