Results 31 to 40 of about 10,044 (209)

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Recombinant Virus Quantification Using Single-Cell Droplet Digital PCR: A Method for Infectious Titer Quantification

Viruses, 2023
The quantification of viruses is necessary for both research and clinical applications. The methods available for RNA virus quantification possess several drawbacks, including sensitivity to inhibitors and the necessity of a standard curve generation ...
Ksenija Korotkaja, Anna Zajakina
doaj   +1 more source

Immunopathogenesis of alphaviruses

, 2020
Alphaviruses, members of the enveloped, positive-sense, single-stranded RNA Togaviridae family, represent a reemerging public health threat as mosquito vectors expand into new geographic territories. The Old World alphaviruses, which include chikungunya virus, Ross River virus, and Sindbis virus, tend to cause a clinical syndrome characterized by fever,
Victoria K, Baxter, Mark T, Heise
openaire   +3 more sources

Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus Biology

Viruses, 2021
RNA viruses cause a wide range of human diseases that are associated with high mortality and morbidity. In the past decades, the rise of genetic-based screening methods and high-throughput sequencing approaches allowed the uncovering of unique and ...
Yogy Simanjuntak, Kira Schamoni-Kast, Alice Grün, Charlotte Uetrecht, Pietro Scaturro   +4 more
doaj   +1 more source

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Viruses, 2021
Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations ...
Ivanildo P. Sousa, Flavia B. dos Santos, Vanessa S. de Paula, Tuane C.R.G. Vieira, Helver G. Dias, Caroline A. Barros, Edson E. da Silva   +6 more
doaj   +1 more source

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors

Microorganisms, 2021
Despite the emerging threat of the Mayaro virus (MAYV) in Central and South-America, there are no licensed antivirals or vaccines available for this neglected mosquito-borne virus.
Lana Langendries, Rana Abdelnabi, Johan Neyts, Leen Delang   +3 more
doaj   +1 more source

Arthritogenic alphaviruses: epidemiological and clinical perspective on emerging arboviruses

, 2020
Mosquito-borne viruses, or arboviruses, have been part of the infectious disease landscape for centuries, and are often, but not exclusively, endemic to equatorial and subtropical regions of the world.
Liu, Xiang, Burt, Felicity, Zaid, Ali, Mahalingam, Suresh, Zandi, Keivan, Suhrbier, Andreas, Weaver, Scott, Texeira, Mauro, Poo, Yee Suan   +8 more
core   +1 more source

Arthrogenic Alphaviruses and Inflammatory Myopathies [PDF]

, 2011
There is increasing evidence to suggest that viruses have aetiological roles in the idiopathic inflammatory myopathies. Arthrogenic alphaviruses (such as chikungunya virus, Ross River virus and sindbis virus) are known to cause outbreaks of polyarthritis
Suresh Mahalingam, Mahalingam, Suresh, Lara Herrero, Herrero, Lara   +3 more
core   +1 more source

Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins

Pathogens, 2023
Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Sofia E. Delgado-Rodriguez, Andrew P. Ryan, Matthew D. Daugherty   +2 more
doaj   +1 more source

Clinical Manifestations of Arthritogenic Alphaviruses

, 2016
Increasing geographical range and the ability of alphaviruses to cause major disease outbreaks highlight their growing importance in clinical practice. Alphaviruses are now the most common cause of infectious arthritis worldwide.
Taylor, Adam, Suan Sin Foo, Roberts, Lynden, Foo, Jolin, Mahalingam, Suresh, Lynden Roberts, Adam Taylor, Lara J. Herrero, Herrero, Lara, Foo, Suan Sin, Ketheesan, Natkuman, Ketheesan, Natkunam, Natkunam Ketheesan, Suresh Mahalingam, Herrero, Lara J   +14 more
core   +1 more source