Results 11 to 20 of about 13,308 (216)

Alphaviruses in Gene Therapy [PDF]

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +6 more sources

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +6 more sources

An Investigation of Culicoides (Diptera: Ceratopogonidae) as Potential Vectors of Medically and Veterinary Important Arboviruses in South Africa

Viruses, 2021
Culicoides-borne viruses such as bluetongue, African horse sickness, and Schmallenberg virus cause major economic burdens due to animal outbreaks in Africa and their emergence in Europe and Asia.
Jumari Snyman, Gert J. Venter, Marietjie Venter   +2 more
doaj   +1 more source

Antiviral Strategies against Arthritogenic Alphaviruses

Microorganisms, 2020
Alphaviruses are members of the Togaviridae family that are mainly transmitted by arthropods such as mosquitoes. In the last decades, several alphaviruses have re-emerged, causing outbreaks worldwide. One example is the re-emergence of chikungunya virus (
Rana Abdelnabi, Leen Delang
doaj   +1 more source

Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells [PDF]

Advances in Virology, 2011
Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans. Their potential threat to human health was most recently exemplified by the 2005 Chikungunya virus outbreak in La Reunion ...
Jason Yat-Sing Leung, Mary Mah-Lee Ng, Justin Jang Hann Chu   +2 more
openaire   +4 more sources

Establishment of an Alphavirus-Specific Neutralization Assay to Distinguish Infections with Different Members of the Semliki Forest complex

Viruses, 2019
Background: Alphaviruses are transmitted by arthropod vectors and can be found worldwide. Alphaviruses of the Semliki Forest complex such as chikungunya virus (CHIKV), Mayaro virus (MAYV) or Ross River virus (RRV) cause acute febrile illness and long ...
Lisa Henss, Constanze Yue, Joshua Kandler, Helen M. Faddy, Graham Simmons, Marcus Panning, Lia Laura Lewis-Ximenez, Sally A. Baylis, Barbara S. Schnierle   +8 more
doaj   +1 more source

Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells

Microbiology Spectrum, 2023
Most alphaviruses are transmitted by mosquito vectors and infect a wide range of vertebrate hosts, with a few exceptions. Eilat virus (EILV) in this genus is characterized by a host range restricted to mosquitoes. Its chimeric viruses have been developed
Lu Tan, Yiwen Zhang, Dal Young Kim, Runsheng Li   +3 more
doaj   +1 more source

Immunopathogenesis of alphaviruses

, 2020
Alphaviruses, members of the enveloped, positive-sense, single-stranded RNA Togaviridae family, represent a reemerging public health threat as mosquito vectors expand into new geographic territories. The Old World alphaviruses, which include chikungunya virus, Ross River virus, and Sindbis virus, tend to cause a clinical syndrome characterized by fever,
Victoria K, Baxter, Mark T, Heise
openaire   +3 more sources