Evolutionary Profile of Mayaro Virus in the Americas: An Update into Genome Variability [PDF]
VirusesThe Mayaro virus (MAYV) is an arbovirus with emerging potential, though with a limited understanding of its epidemiology and evolution due to the lack of studies and surveillance. Here, we investigated 71 MAYV genome sequences from the Americas available
Mikaela dos Santos Marinho +6 more
doaj +4 more sources
Eugenol-Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights. [PDF]
J Med VirolABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Reis ACC +9 more
europepmc +2 more sources
Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil?
Brazilian Journal of Infectious Diseases, 2017 Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade ...
Danillo Lucas Alves Esposito +1 more
doaj +3 more sources
Mouse Models of Mayaro Virus [PDF]
Viruses, 2023 Mayaro virus (MAYV), the etiologic agent of Mayaro fever, leads patients to severe myalgia and arthralgia, which can have a major impact on public health in all the countries where the virus circulates. The emergence and dissemination of new viruses have
Rafael Borges Rosa +4 more
doaj +2 more sources
Microorganisms, 2021 Despite the emerging threat of the Mayaro virus (MAYV) in Central and South-America, there are no licensed antivirals or vaccines available for this neglected mosquito-borne virus.
Lana Langendries +3 more
doaj +3 more sources
A comprehensive murine clinical model for development of countermeasures and studying Mayaro virus infection. [PDF]
PLoS Neglected Tropical DiseasesThe Mayaro virus (MAYV) is an arthropod-borne virus that causes Mayaro fever, a neglected tropical disease that produces disabling arthralgia. Given the significant threat the dissemination of MAYV poses to global public health, the development of animal
Rafael Borges Rosa +11 more
doaj +2 more sources
Mayaro Virus Pathogenesis and Transmission Mechanisms
Pathogens, 2020 Mayaro virus (MAYV), isolated for the first time in Trinidad and Tobago, has captured the attention of public health authorities worldwide following recent outbreaks in the Americas.
Cheikh Tidiane Diagne +5 more
doaj +3 more sources
Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein [PDF]
npj VaccinesVirus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both humoral and cellular immune responses against a range of pathogens. Here, we show by cryo-electron microscopy that VLPs of Mayaro virus,
Young Chan Kim +13 more
doaj +2 more sources
Molecular Epidemiology of Mayaro Virus among Febrile Patients, Roraima State, Brazil, 2018–2021 [PDF]
Emerging Infectious DiseasesWe detected Mayaro virus (MAYV) in 3.4% (28/822) of febrile patients tested during 2018–2021 from Roraima State, Brazil. We also isolated MAYV strains and confirmed that these cases were caused by genotype D.
Julia Forato +16 more
doaj +2 more sources
Mayaro Virus: An Emerging Alphavirus in the Americas [PDF]
VirusesYoung Chan Kim
exaly +2 more sources