Results 51 to 60 of about 13,308 (216)

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

Frontiers in Cellular Neuroscience, 2014
The central nervous system (CNS) is a highly complex network comprised of long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain.
Daniela eMichlmayr, Jean K Lim
doaj   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents

Viruses
Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world.
Kenneth Lundstrom
doaj   +1 more source

Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses [PDF]

Open Biology, 2019
Arboviruses that are transmitted to humans by mosquitoes represent one of the most important causes of febrile illness worldwide. In recent decades, we have witnessed a dramatic re-emergence of several mosquito-borne arboviruses, including dengue virus ...
Liliana Echavarria-Consuegra, Jolanda M. Smit, Fulvio Reggiori   +2 more
doaj   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S., Strauss, Ellen G., Strauss, James H.   +2 more
core   +1 more source

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus [PDF]

, 2003
Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses.
AJ Johnson, BD Lindenbach, BU Barth, CT Jones, DLD Caspar, DS Burke, DWC Beasley, EJ Mancini, FA Rey, FX Heinz, GW Smith, IC Lorenz, J Lescar, James H Strauss, Jeroen Corver, JH Strauss, JH Strauss, JJB Cockburn, JT Roehrig, K Stiasny, LJ McGuffin, MG Rossmann, MG Rossmann, Michael G Rossmann, ML Ng, N Grigorieff, Paul R Chipman, Peter R Johnson, PJL Werten, Richard J Kuhn, RJ Kuhn, S Bhardwaj, S Elshuber, S Lee, SL Allison, SL Allison, Suchetana Mukhopadhyay, T Solomon, Timothy S Baker, U Skoging, VM Unger, W Zhang, WD Crill, Wei Zhang, Y Ji, Y Modis, Y Zhang, Ying Zhang, YS Hahn   +48 more
core   +1 more source

Land‐Based Functional Rehabilitation Versus Aquatic Therapy on the Quality of Life of Individuals With Chronic Chikungunya: A Randomized Clinical Trial

Physiotherapy Research International, Volume 31, Issue 3, July 2026.
ABSTRACT Background and Purpose Chikungunya may progress to a chronic phase marked by persistent pain and functional impairment, reducing the quality of life. Exercise‐based rehabilitation is essential, though comparisons between different modalities remain scarce. Exercises in an aquatic environment can be designed as a task‐oriented intervention that
Oliva Maria da Silva Sousa, Marynara Fabíola Silva Araújo, Geilson Medeiros de Araújo, Hilmaynne Renaly Fonseca Fialho, Renata Newman Leite dos Santos Lucena, Eleazar Marinho de Freitas Lucena   +5 more
wiley   +1 more source

Circulation of 2 Barmah Forest Virus Lineages in Military Training Areas, Australia

Emerging Infectious Diseases, 2020
During 2017–2018, Barmah Forest virus was recovered from mosquitoes trapped in military training areas in Australia and from a soldier infected at 1 of these areas.
Wenjun Liu, Joanne R. Kizu, David R. Matley, Richard Grant, Fiona J. McCallum, Christopher G. Moller, Tracy L. Carthew, Jun Hang, Ania J. Gubala, John G. Aaskov   +9 more
doaj   +1 more source

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses [PDF]

, 2017
The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies.
Donald, Claire L., Kohl, Alain, Merits, Andres, Royle, Jamie, Varjak, Margus   +4 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source