Results 51 to 60 of about 12,699 (245)
, 2016 Alphaviruses comprise a fascinating group of small, enveloped single-stranded positive-sense RNA viruses. They are usually transmitted by arthropod vectors (usually mosquitoes).
Mahalingam, Suresh +2 more
core +1 more source
Perspectives for applying Alphaviruses in antitumor therapy
Инфекция и иммунитет, 2023 Oncolytic viral therapy is a promising approach for treating tumors. Oncolytic viruses can directly lyse tumor cells and indirectly activate antitumor immunity.
Alina S. Nazarenko +5 more
doaj +1 more source
Neuropathogenesis of Encephalitic Alphaviruses in Non-Human Primate and Mouse Models of Infection
PathogensEncephalitic alphaviruses, including eastern, Venezuelan, and western equine encephalitis virus (EEEV, VEEV, and WEEV, respectively) are New World alphaviruses primarily transmitted by mosquitos that cause debilitating and lethal central nervous system ...
Caitlin M. Woodson +2 more
semanticscholar +1 more source
Clinical Manifestations of Arthritogenic Alphaviruses
, 2016 Increasing geographical range and the ability of alphaviruses to cause major disease outbreaks highlight their growing importance in clinical practice. Alphaviruses are now the most common cause of infectious arthritis worldwide.
Taylor, Adam +11 more
core +1 more source
Packaging signals in alphaviruses [PDF]
Journal of Virology, 1997 Alphaviruses synthesize large amounts of both genomic and subgenomic RNA in infected cells, but usually only the genomic RNA is packaged. This implies the existence of an encapsidation or packaging signal which would be responsible for selectivity. Previously, we had identified a region of the Sindbis virus genome that interacts specifically with the ...
E, Frolova, I, Frolov, S, Schlesinger
openaire +2 more sources
LDLR is used as a cell entry receptor by multiple alphaviruses
Nature CommunicationsAlphaviruses are arboviruses transmitted by mosquitoes and are pathogenic to humans and livestock, causing a substantial public health burden. So far, several receptors have been identified for alphavirus entry; however, they cannot explain the broad ...
Xiao-Feng Zhai +14 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the Togaviridae family.
L. De Caluwé +8 more
semanticscholar +1 more source
Viruses, 2014 Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
doaj +1 more source
The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses
Nature CommunicationsMembers of the low-density lipoprotein receptor (LDLR) family, including LDLRAD3, VLDLR, and ApoER2, were recently described as entry factors for different alphaviruses.
Hong-Ming Ma +8 more
semanticscholar +1 more source
Journal of Virology, 2022 Alphaviruses are human pathogens that cause both debilitating acute and chronic musculoskeletal disease and potentially fatal encephalitis. In this study, we determined that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein ...
Cormac J. Lucas +4 more
semanticscholar +1 more source