Results 71 to 80 of about 12,699 (245)

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

Frontiers in Cellular Neuroscience, 2014
The central nervous system (CNS) is a highly complex network comprised of long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain.
Daniela eMichlmayr, Jean K Lim
doaj   +1 more source

Venezuelan Equine Encephalitis Complex Alphavirus in Bats, French Guiana

Emerging Infectious Diseases, 2021
Although essential for control strategies, knowledge about transmission cycles is limited for Venezuelan equine encephalitis complex alphaviruses (VEEVs).
Carlo Fischer, Dominique Pontier, Ondine Filippi-Codaccioni, Jean-Batiste Pons, Ignacio Postigo-Hidalgo, Jeanne Duhayer, Sebastian Brünink, Jan Felix Drexler   +7 more
doaj   +1 more source

An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques

Science Translational Medicine
Venezuelan (VEEV), Eastern (EEEV), and Western (WEEV) equine encephalitis viruses are mosquito-transmitted alphaviruses in the family Togaviridae with the potential to cause fatal neuroinvasive disease in humans.
L. K. Metthew Lam, Theron Gilliland, Matthew D. Dunn, Maria D Alcorn-Burckhardt, Yutaka Terada, Cheng-Qun Sun, Shauna Vasilatos, Morgan Midgett, Connor Williams, Amanda Laughlin, Jeneveve D. Lundy, Christina L. Gardner, Archana Thomas, H. Raué, H. Gertje, A. O'Connell, N. Crossland, Douglas S. Reed, Michael S. Diamond, M. Slifka, W. Klimstra   +20 more
semanticscholar   +1 more source

Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Arthritogenic alphaviruses, such as Chikungunya virus (CHIKV) and Mayaro virus (MAYV), cause febrile illness, rash, and a debilitating chronic polyarthritis in humans.
Ryan J. Malonis, J. T. Earnest, A. Kim, Matthew Angeliadis, Frederick W. Holtsberg, M. Aman, R. Jangra, K. Chandran, J. Daily, M. Diamond, M. Kielian, Jonathan R. Lai   +11 more
semanticscholar   +1 more source

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Differential susceptibility of human microglia HMC3 cells and brain microvascular endothelial HBEC-5i cells to Mayaro and Una virus infection

Frontiers in Virology
Mayaro (MAYV) and Una (UNAV) are emerging alphaviruses circulating in the Americas. Earlier reports have revealed that MAYV infects different human cell lines, including synovial and dermal fibroblasts, chondrocytes, osteoblasts, astrocytes and pericytes,
Dalkiria Campos, Madelaine Sugasti-Salazar, Madelaine Sugasti-Salazar, Patricia Valdés-Torres, Patricia Valdés-Torres, Paola Elaine Galán-Jurado, Dalel Zegarra, Dalel Zegarra, José González-Santamaría   +8 more
doaj   +1 more source

Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses [PDF]

Open Biology, 2019
Arboviruses that are transmitted to humans by mosquitoes represent one of the most important causes of febrile illness worldwide. In recent decades, we have witnessed a dramatic re-emergence of several mosquito-borne arboviruses, including dengue virus ...
Liliana Echavarria-Consuegra, Jolanda M. Smit, Fulvio Reggiori   +2 more
doaj   +1 more source

The impact of temperature and insect-specific viruses on the transmission of alphaviruses by Aedes japonicus japonicus

Microbiology spectrum
Arthropod-borne virus (arbovirus) infections are increasing globally, and invasive mosquito species are spreading. Since the end of the last century, Aedes japonicus has continued to spread in Europe as well as in North America.
S. Jansen, Dániel Cadar, J. Hey, Michelle Helms, U. Lange, Balázs Horváth, H. Jöst, W. Pfitzner, Jonas Schmidt-Chanasit, R. Lühken, A. Heitmann   +10 more
semanticscholar   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

Animal Models of Alphavirus-induced Inflammatory Disease

, 2016
Animal models that reflect key aspects of human disease are invaluable tools for understanding the mechanisms of disease pathogenesis and development of treatment strategies.
Taylor, Adam, Pierre Roques, Suresh Mahalingam, Mahalingam, Suresh, Adam Taylor, Lidbury, Brett A, Herrero, Lara J, Roques, Pierre, Lara J. Herrero, Brett A. Lidbury   +9 more
core   +1 more source