Results 71 to 80 of about 9,502 (198)
Basic Characteristics of Medically Important Alphaviruses (Togaviridae) [PDF]
Özet Uluslararası Virüs Sınıflandırma Komitesi (International Committee on Taxonomy of Viruses; ICTV) tarafından yayımlanan raporlara göre tür düzeyinde tanımlanan virüslerin sayısı son birkaç yılda 5.561’den (ICTV 2018b) 9.110’a (ICTV 2020) ulaşmıştır.
Şahiner, Fatih
core +1 more source
Structural insights into host-pathogen interactions of alphaviruses [PDF]
Alphaviruses are arthropod-borne, single-stranded positive-sense RNA viruses of the Togaviridae family that infect various vertebrates worldwide in tropical and temperate areas, causing emerging and reemerging diseases in humans. Mature virions are 70 nm
Basore, Katherine
core +2 more sources
Spindle-E acts antivirally against alphaviruses in mosquito cells [PDF]
Mosquitoes transmit several human- and animal-pathogenic alphaviruses (Togaviridae family). In alphavirus-infected mosquito cells two different types of virus-specific small RNAs are produced as part of the RNA interference response: short-interfering (
Sreenu, Vattipally B. +20 more
core +1 more source
The alphaviruses: gene expression, replication, and evolution [PDF]
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
core
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2 [PDF]
Bcl-2 oncogene expression plays a role in the establishment of persistent viral infection by blocking virus-induced apoptosis. This might be achieved by preventing virus-induced activation of caspase-3, an IL-1beta-converting enzyme (ICE)-like cysteine ...
Grandgirard, Denis +6 more
core +1 more source
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat +11 more
wiley +1 more source
A customized program for the identification of conserved protein sequence motifs
We searched for viral protein sequences that could be important for tissue tropism. To achieve this goal, human pathogenic viruses were classified according to the tissue they infect (e.g., pulmonary), irrespective of whether they were enveloped or non ...
Mohammad Mian +7 more
doaj +1 more source
Dengue Virus Capsid Protein Interaction With Nucleic Acids
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva +7 more
wiley +1 more source
Many vector-borne viruses are re-emerging as public health threats, yet our understanding of the virus–host interactions critical for productive infection remains limited. The ubiquitination of proteins, including host- and pathogen-derived proteins is a
Sanskruthi Sreepangi +7 more
doaj +1 more source
ABSTRACT Post‐dengue fatigue syndrome is a debilitating long‐term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post‐dengue depression complicate differentiation.
Anna Condé +6 more
wiley +1 more source

