Results 81 to 90 of about 12,699 (245)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, Volume 6, Issue 5, October 2026.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Circulation of 2 Barmah Forest Virus Lineages in Military Training Areas, Australia

Emerging Infectious Diseases, 2020
During 2017–2018, Barmah Forest virus was recovered from mosquitoes trapped in military training areas in Australia and from a soldier infected at 1 of these areas.
Wenjun Liu, Joanne R. Kizu, David R. Matley, Richard Grant, Fiona J. McCallum, Christopher G. Moller, Tracy L. Carthew, Jun Hang, Ania J. Gubala, John G. Aaskov   +9 more
doaj   +1 more source

First Record of Mosquito-Borne Kyzylagach Virus in Central Europe

Viruses, 2020
RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová, Patrik Dočkal, Petra Straková, Jan Mendel, Oldřich Šebesta, Lenka Betášová, Hana Blažejová, Zdeněk Hubálek, Ivo Rudolf   +8 more
doaj   +1 more source

The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses

Cell Reports
SUMMARY The very-low-density lipoprotein receptor (VLDLR) has been reported as an entry receptor for Semliki Forest (SFV) and Eastern equine encephalitis (EEEV) alphaviruses in cell cultures.
Sathvik Palakurty, S. Raju, Alan Sariol, Zhen-Lu Chong, Ngan Wagoner, Hong-Ming Ma, O. Zimmerman, L. Adams, C. Carmona, Zhuo-Ming Liu, D. Fremont, Sean P. J. Whelan, W. Klimstra, Michael S. Diamond   +13 more
semanticscholar   +1 more source

Diagnosis and Management of Infectious Encephalitis in Adults: Guidelines From the European Academy of Neurology and European Society of Clinical Microbiology and Infectious Diseases

European Journal of Neurology, Volume 33, Issue 10, October 2026.
ABSTRACT Background Encephalitis is difficult to diagnose and manage, posing a challenge to clinicians. Since the last European guidelines were published in 2010, novel causes have emerged, diagnostic processes have evolved and treatments assessed which need to be reflected in updated guidelines.
Julia Granerod, Johann Sellner, Jean‐Paul Stahl, Sylviane Defres, Alexandra Mailles, Erich Schmutzhard, Elisabeth Aurelius, Thomas Whitfield, Luca Massacesi, Maarten J. Titulaer, Pille Taba, Benedict D. Michael, Tehmina Bharucha, Lance Turtle, Brendan Sargent, Arina Tamborska, Jonathan Cattrall, Yun Huang, Eva Maria Hodel, Suzannah Lant, Glynn Webb, Rajish S. K. Shil, Shalley Dhar, Diederik van de Beek, Marie Studahl, Matthijs C. Brouwer, Uta Meyding‐Lamade, Ava Easton, Bhagteshwar Singh, Tom Solomon   +29 more
wiley   +1 more source

Cryogenic electron microscopy and tomography reveal imperfect icosahedral symmetry in alphaviruses

PNAS Nexus
Alphaviruses are spherical, enveloped RNA viruses with two-layered icosahedral architecture. The structures of many alphaviruses have been studied using cryogenic electron microscopy (cryo-EM) reconstructions, which impose icosahedral symmetry on the ...
D. Chmielewski, Guan-Chin Su, J. Kaelber, G. Pintilie, Mu-Yuan Chen, Jing Jin, A. J. Auguste, Wah Chiu   +7 more
semanticscholar   +1 more source

Design, evaluation, and validation of specific primers for accurate detection of VHS virus in rainbow trout (Oncorhynchus mykiss)

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract Accurate detection of Piscine novirhabdovirus (PNRV), also know as viral hemorrhagic septicemia virus (VHSV) in rainbow trout (Oncorhynchus mykiss) is essential for effective aquaculture disease management. This study developed strain‐inclusive primers targeting the conserved glycoprotein (G) gene using integrated bioinformatics approaches ...
Mohammad Kazem Momeni, Mohsen Mobini‐Dehkordi, Amin Nematollahi   +2 more
wiley   +1 more source

Chikungunya Virus and (Re-) Emerging Alphaviruses

, 2019
Alphaviruses belong to a family of positive sense, single-stranded RNA viruses that are transmitted mainly by mosquitoes through a blood meal and cause arthritis and/or encephalitis in humans and animals [...
Penghua Wang, Rong Zhang
core   +1 more source

Prevalence of antibodies to equine alphaviruses in the State of Pará, Brazil

, 2016
: The State of Pará comprises 26% of Brazilian Amazon region, where a large diversity of arboviruses has been described. This study sought to assess the prevalence and distribution of hemagglutination inhibition (HI) antibodies against antigens of four ...
Martins, Lívia Caricio, Chiang, Jannifer Oliveira, Silva, Sandro Patroca da, Jannifer Oliveira Chiang, Henriques, Daniele Freitas, Casseb, Lívia Medeiros Neves, Daniele Freitas Henriques, Casseb, Alexandre do Rosário, Thais Costa Brito, Pedro Fernando da Costa Vasconcelos, Maria Rogéria Menezes da Silva, Silva, Maria Rogéria Menezes da, Sandro Patroca da Silva, Brito, Thais Costa, Alexandre do Rosário Casseb, Livia Medeiros Neves Casseb, Vasconcelos, Pedro Fernando da Costa, Lívia Caricio Martins   +17 more
core   +2 more sources

Co-circulation of two Alphaviruses in Burkina Faso: Chikungunya and O’nyong nyong viruses

PLoS Neglected Tropical Diseases
Background Chikungunya virus (CHIKV) and O’nyong nyong virus (ONNV) are phylogenetically related alphaviruses in the Semliki Forest Virus (SFV) antigenic complex of the Togaviridae family. There are limited data on the circulation of these two viruses in
B. Tinto, Brice W. Bicaba, T. Kagoné, J. Kayiwa, I. Rabe, Corinne S. Merle, Alidou Zango, A. Ayouba, Sara Salinas, D. Kania, Y. Simonin   +10 more
semanticscholar   +1 more source