Results 81 to 90 of about 9,502 (198)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Mayaro virus: Complete nucleotide sequence and phylogenetic relationships with other alphaviruses [PDF]

, 2006
International audienceMayaro (MAY) virus is a member of the genus Alphavirus in the family Togaviridae. Alphaviruses are distributed throughout the world and cause a wide range of diseases in humans and animals.
Mercier, Véronique, Thoisy, Benoit de, Pascalis, Hervé, Morvan, Jacques, Lacoste, Vincent, Kazanji, Mirdad, Tolou, Hugues, Dussart, Philippe, Lavergne, Anne, Pouliquen, Jean-François, Talarmin, Antoine   +10 more
core   +1 more source

LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Nature Communications
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor
Ningning Wang, Andres Merits, Michael Veit, Laura Sandra Lello, Shuhan Kong, Houqi Jiao, Jie Chen, Yu Wang, Georgi Dobrikov, Félix A. Rey, Shuo Su   +10 more
doaj   +1 more source

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Anais da Academia Brasileira de Ciências
Alphaviruses among the viruses that cause arthritis, consisting in a public health problem worldwide by causing localized outbreaks, as well as large epidemics in humans.
MARIANA G. CAVALHEIRO, LEANDRO SILVA DA COSTA, HOLMES S. CAMPOS, LETÍCIA S. ALVES, IRANAIA ASSUNÇÃO-MIRANDA, ANDREA T. DA POIAN   +5 more
doaj   +1 more source

Vector‐borne diseases‐knowledge maps

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This scientific report provides a structured overview of the main characteristics of 25 selected vector‐borne diseases (VBDs) of potential relevance for the EU, including 12 diseases listed under the Animal Health Law (AHL) and 13 non‐listed diseases.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source

Cross-reactivity profiles of anti-CHIKV mAbs against cells infected with other alphaviruses. [PDF]

, 2018
Cross-reactivity profiles of anti-CHIKV mAbs against cells infected with other alphaviruses.
Pornsawan Leaungwutiwong (2836934), Kevin K. Ariën (138061), Tadahiro Sasaki (114367), Tatsuo Shioda (126910), Aekkachai Tuekprakhon (6091484), Emi E. Nakayama (126892), Ralph Huits (5154785), Orapim Puiprom (538715), Juthamas Phadungsombat (5954687), Michael K. Meno (6091487), Johan Michiels (138057), Natthanej Luplertlop (233145), Koen Bartholomeeusen (109461)   +12 more
core   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, Volume 13, Issue 22, 17 April 2026.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Genomic characterization and seroprevalence studies on alphaviruses in Uruguay [PDF]

, 2018
Alphaviruses (Togaviridae) are arboviruses frequently associated with emerging infectious diseases. In this study, we aimed to investigate the presence of alphaviruses in Uruguay by detecting the viral genome in mosquitoes and neutralizing antibodies in ...
Cabrera Castro, Andrés M., Rivarola, M. E., Díaz, L. A., Contigiani, M., Burgueño, Analía, Delfraro Vázquez, Adriana Beatriz, Frabasile Giurato, Sandra Alicia, Pisano, María Belén   +7 more
core   +3 more sources

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.

PLoS Pathogens
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan   +9 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source