Results 81 to 90 of about 10,044 (209)
LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Nature CommunicationsVarious low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor
Ningning Wang +10 more
doaj +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1167-1179, June 2026.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Chikungunya Virus and (Re-) Emerging Alphaviruses
, 2019 Alphaviruses belong to a family of positive sense, single-stranded RNA viruses that are transmitted mainly by mosquitoes through a blood meal and cause arthritis and/or encephalitis in humans and animals [...
Penghua Wang, Rong Zhang
core +1 more source
PLoS PathogensAlphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie +9 more
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Plasmid DNA-based Alphavirus Vaccines
Vaccines, 2019 Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
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Broad Antiviral Activity of Ginkgolic Acid against Chikungunya, Mayaro, Una, and Zika Viruses
Viruses, 2020 The alphaviruses Chikungunya (CHIKV), Mayaro (MAYV), Una (UNAV), and the flavivirus Zika (ZIKV) are emerging or re-emerging arboviruses which are responsible for frequent epidemic outbreaks. Despite the large impact of these arboviruses on health systems,
Dalkiria Campos +4 more
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Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat +11 more
wiley +1 more source
Dengue Virus Capsid Protein Interaction With Nucleic Acids
BioFactors, Volume 52, Issue 3, May/June 2026.Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva +7 more
wiley +1 more source
Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus
VirusesThe genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral
Belinda Baquero-Pérez +7 more
doaj +1 more source
VaccinesThe first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber +16 more
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