Results 101 to 110 of about 13,213 (215)

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ^®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow   +16 more
doaj   +1 more source

Sequence coding for the alphavirus nonstructural proteins is interrupted by an opal termination codon [PDF]

, 1983
We have obtained the nucleotide sequence of the genomic RNAs of two alphaviruses, Sindbis virus and Middelburg virus, over an extensive region encoding the nonstructural (replicase) proteins.
Rice, Charles M., Strauss, Ellen G., Strauss, James H.   +2 more
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Expression, Enzymatic Activities and Subcellular Localization of Hepatitis E Virus and Semliki Forest Virus Replicase Proteins [PDF]

, 2006
Viruses are submicroscopic, infectious agents that are obligate intracellular parasites. They adopt various types of strategies for their parasitic replication and proliferation in infected cells.
Perttilä, Julia
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Identification and Characterization of a Ross River Virus Variant That Grows Persistently in Macrophages, Shows Altered Disease Kinetics in a Mouse Model, and Exhibits Resistance to Type I Interferon [PDF]

, 2011
Alphaviruses, such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV), cause outbreaks of human rheumatic disease worldwide. RRV is a positive-sense single-stranded RNA virus endemic to Australia and Papua New Guinea. In this study, we
A. Lidbury, Brett, B. Cossetto, Susan, M. Musso, Cristina, Mahalingam, Suresh, Rolph, Michael, Rulli, Nestor, S. Rothenfluh, Harald, Suhrbier, Andreas, Zaid, Ali   +8 more
core   +4 more sources

Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines

Viruses
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Ayşegül Yıldız, Cristian Răileanu, Tim Beissert   +2 more
doaj   +1 more source

Advances in dissecting mosquito innate immune responses to arbovirus infection [PDF]

, 2009
Arthropod-borne viruses – arboviruses – are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control ...
A. A. Nash, A. Kohl, Aliyari, Alphey, Barillas-Mury, Barillas-Mury, Best, Blair, Blitvich, Borucki, Bowers, Bowie, Campbell, Campbell, Caudy, Caudy, Christophides, Christophides, Cirimotich, Condreay, Deddouche, Deo, Ding, Dostert, Ferrandon, Fragkoudis, G. Attarzadeh-Yazdi, Galiana-Arnoux, Garcia, Garcia, Garmashova, Geiss, Gillies, Gillies, Girard, GIRARD, Gordon, Gordon, Gould, Halstead, Hedges, Hedges, Hirai, Holt, J. K. Fazakerley, Jiravanichpaisal, Kang, Karpf, Kemp, Kuno, Kyle, Landeg, Lemaitre, Li, Li, Lin, McMeniman, Medeiros, Mims, Molnar, Newton, Obbard, Olson, Osta, Papanayotou, Parikh, Powers, R. Fragkoudis, Randall, Robalino, Robalino, Sabatier, Saleh, Sanchez-Vargas, Sanchez-Vargas, Sanders, Scholthof, Shelly, Sim, Sim, Soldan, Tortosa, Travanty, van Rij, van Rij, Voinnet, Wang, Waterhouse, Weaver, Weaver, Weaver, Weaver, Whitten, Xi, Xie, Yoneyama, Zambon, Zelivianski   +97 more
core   +1 more source

Future Developments and Applications of the Vaccines against Dangerous Viral Infections, RNA-Replicon-Based, Obtained from the Venezuelan Equine Encephalomyelitis Virus

Проблемы особо опасных инфекций, 2014
The members of the Filoviridae (Marburg and Ebola viruses) and Arenaviridae (Lassa, Lujo, Machupo, Junin, Guanarito, Sabia viruses) families are the etiological agents of particularly dangerous viral hemorrhagic fevers.
A. A. Petrov, V. N. Lebedev, T. M. Plekhanova, L. F. Stobva, O. N. Sidorova, E. V. Mel’Nikova, S. V. Borisevich   +6 more
doaj   +1 more source

Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

Emerging Infectious Diseases, 2009
In 1993, an outbreak of encephalitis among 125 affected equids in coastal Chiapas, Mexico, resulted in a 50% case-fatality rate. The outbreak was attributed to Venezuelan equine encephalitis virus (VEEV) subtype IE, not previously associated with equine ...
Eleanor R. Deardorff, Naomi L. Forrester, Amelia P. Travassos da Rosa, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Robert B. Tesh, Nikos Vasilakis   +6 more
doaj   +1 more source

Pseudotyped Lentiviral Vectors: One Vector, Many Guises [PDF]

, 2017
Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene transfer to desired cells.
Joglekar, Alok V., Sandoval, Salemiz
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Mechanism of membrane tube formation induced by adhesive nanocomponents

, 2012
We report numerical simulations of membrane tubulation driven by large colloidal particles. Using Monte Carlo simulations we study how the process depends on particle size, concentration and binding strength, and present accurate free energy calculations
A. H. Bahrami, Angelo Cacciuto, Anđela Šarić, H. Garoff   +3 more
core   +1 more source