Results 91 to 100 of about 9,502 (198)

Plasmid DNA-based Alphavirus Vaccines

Vaccines, 2019
Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
doaj   +1 more source

Broad Antiviral Activity of Ginkgolic Acid against Chikungunya, Mayaro, Una, and Zika Viruses

Viruses, 2020
The alphaviruses Chikungunya (CHIKV), Mayaro (MAYV), Una (UNAV), and the flavivirus Zika (ZIKV) are emerging or re-emerging arboviruses which are responsible for frequent epidemic outbreaks. Despite the large impact of these arboviruses on health systems,
Dalkiria Campos, Susana Navarro, Yessica Yadira Llamas-González, Madelaine Sugasti, José González-Santamaría   +4 more
doaj   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Development and application of molecular assays for mosquito-borne alphaviruses in South Africa [PDF]

, 2021
Dissertation (M.Sc. (Medical Microbiology and Virology))--University of the Free State, 2021Surveillance of mosquito-borne alphaviruses is critical for the prevention of diseases and the control of outbreaks caused by these viruses, especially with the ...
Dimaculangan, Micah
core  

Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus

Viruses
The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral
Belinda Baquero-Pérez, Enrico Bortoletto, Umberto Rosani, Anna Delgado-Tejedor, Rebeca Medina, Eva Maria Novoa, Paola Venier, Juana Díez   +7 more
doaj   +1 more source

Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies [PDF]

, 2022
Alphaviruses are a group of medically relevant arthropod-borne viruses (arboviruses) belonging to the Togaviridae family that are maintained by mosquito vectors.
Webb, Emily Morgan
core  

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ^®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow   +16 more
doaj   +1 more source

PROGRAMMED TRANSLATIONAL RECODING SIGNALS AS A THERAPEUTIC TARGET AGAINST ALPHAVIRUSES [PDF]

, 2018
While infection from communicable diseases has posed a longstanding threat to human health throughout history, the modern realities of population expansion, global travel, and climate change have facilitated the rapid emergence and worldwide distribution
Kendra, Joseph Aaron
core   +1 more source

The Pathogenesis of Alphaviruses [PDF]

ISRN Virology, 2013
Alphaviruses are enveloped single-stranded positive sense RNA viruses of the family Togaviridae. The genus alphavirus contains nine viruses, which are of medical, theoretical, or economic importance, and which will be considered. Sindbis virus (SINV) and Semliki Forest (SFV), although of some medical importance, have largely been studied as models of ...
openaire   +1 more source

How alphaviruses cause disease and identifying new therapeutics. [PDF]

Alphaviruses are transmitted by mosquitoes and cause a variety of serious human infections. This project investigates how alphaviruses cause disease, with special focus on inflammatory musculoskeletal diseases.

core