Results 91 to 100 of about 12,699 (245)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, Volume 42, Issue 5, September/October 2026.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Alphaviruses and their role in elucidating antiviral responses in mosquitoes

, 2016
The interaction between mosquito vectors and arthropod-borne viruses (arboviruses) such as alphaviruses of the Togaviridae family has long been of central interest to virologists.
Kohl, Alain, Melanie McFarlane, Alain Kohl, McFarlane, Melanie   +3 more
core   +1 more source

MARCO+ lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination

EMBO Journal, 2021
Viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity. However, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for the
Kathryn S. Carpentier, Ryan M. Sheridan, Cormac J. Lucas, Bennett J. Davenport, Frances S Li, Erin D. Lucas, M. McCarthy, Glennys V. Reynoso, N. A. May, B. Tamburini, J. Hesselberth, H. Hickman, T. Morrison   +12 more
semanticscholar   +1 more source

mRNA Therapeutics Beyond Infectious Diseases: Expanding Therapeutic Applications and Future Perspectives

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
Messenger RNA therapeutics are rapidly expanding beyond infectious diseases into oncology, autoimmune disorders, protein replacement therapy, cardiovascular and neurological diseases, and regenerative medicine. Advances in RNA engineering and targeted delivery are driving the development of safe, programmable, and precision therapeutics for diverse ...
Gedion Mengistu Dejen
wiley   +1 more source

Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.

, 2021
Mayaro virus (MAYV) is an alphavirus endemic to South and Central America associated with sporadic outbreaks in humans. MAYV infection causes severe joint and muscle pain that can persist for weeks to months.
Thomas E Morrison, Nicholas Kreklywich, Mark T Heise, Takeshi Ando, Michael Denton, Victor DeFilippis, Rebecca Broeckel, Kiley Bonin, John M Powers, Craig Kreklywich, Nicole N Haese, Cassilyn E Streblow, Daniel N Streblow, Patricia Smith, Cassilyn E. Streblow, Daniel N. Streblow, John M. Powers, Mark T. Heise, Nicole N. Haese, Thomas E. Morrison   +19 more
core   +1 more source

Evidence of Differences in Cellular Regulation of Wolbachia-Mediated Viral Inhibition between Alphaviruses and Flaviviruses

Viruses
The intracellular bacterium Wolbachia is increasingly being utilised in control programs to limit the spread of arboviruses by Aedes mosquitoes. Achieving a better understanding of how Wolbachia strains can reduce viral replication/spread could be ...
Stephanie M. Rainey, Daniella A. Lefteri, Christie Darby, Alain Kohl, Andres Merits, Steven P. Sinkins   +5 more
doaj   +1 more source

Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

Viruses, 2022
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS).
Niloufar A. Boghdeh, Kenneth H. Risner, Michael D. Barrera, Clayton M. Britt, David K. Schaffer, Farhang Alem, Jacquelyn A. Brown, John P. Wikswo, Aarthi Narayanan   +8 more
doaj   +1 more source

Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Domain

Cell Host and Microbe, 2020
SUMMARY Mosquito inoculation of humans with arthritogenic alphaviruses results in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis.
Laura A. Powell, Andrew S. Miller, J. Fox, Nurgun Kose, T. Klose, A. Kim, Robin Bombardi, Rashika N. Tennekoon, A. D. de Silva, Robert H. Carnahan, M. Diamond, M. Rossmann, R. Kuhn, James E. Crowe   +13 more
semanticscholar   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

Induction of programmed cell death in mammalian cells by isolates of Ross River virus [PDF]

, 2011
Arthritogenic alphaviruses, such as Ross River virus (RRV) are associated with worldwide outbreaks of human polyarthritis/arthralgia. The pathogenesis of RRV and other alphaviruses is poorly understood.
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