Results 31 to 40 of about 10,615 (164)

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]

PLoS Pathogens, 2012
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani, Michael R Wiley, Marta G Murreddu, Zach N Adelman, Kevin M Myles   +4 more
doaj   +1 more source

The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

Cell Reports, 2021
Summary: Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus E2 protein can protect against infection, the functional significance of non-neutralizing mAbs is poorly understood.
James T. Earnest, Autumn C. Holmes, Katherine Basore, Matthias Mack, Daved H. Fremont, Michael S. Diamond   +5 more
doaj   +1 more source

Interactions of Alphavirus nsP3 Protein with Host Proteins

Frontiers in Microbiology, 2018
Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark, Forrest Keck, Aarthi Narayanan   +2 more
doaj   +1 more source

Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.

PLoS Neglected Tropical Diseases, 2017
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud   +9 more
doaj   +1 more source

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +1 more source

Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection. [PDF]

Front Microbiol, 2017
Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival
Ronca SE, Smith J, Koma T, Miller MM, Yun N, Dineley KT, Paessler S.   +6 more
europepmc   +4 more sources

Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]

Journal of Virology, 2015
ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
K J, Sokoloski, K C, Haist, T E, Morrison, S, Mukhopadhyay, R W, Hardy   +4 more
openaire   +2 more sources

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

PLoS Pathogens, 2023
Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert   +6 more
doaj   +1 more source

Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors [PDF]

Journal of Visualized Experiments, 2010
Alphavirus transducing systems (ATSs) are important tools for expressing genes of interest (GOI) during infection. ATSs are derived from cDNA clones of mosquito-borne RNA viruses (genus Alphavirus; family Togaviridae). The Alphavirus genus contains about 30 different mosquito-borne virus species.
Aaron, Phillips, Eric, Mossel, Irma, Sanchez-Vargas, Brian, Foy, Ken, Olson   +4 more
openaire   +2 more sources

Current Understanding of the Role of Cholesterol in the Life Cycle of Alphaviruses

Viruses, 2020
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family ...
Ivanildo P. Sousa, Carlos A. M. Carvalho, Andre M. O. Gomes   +2 more
doaj   +1 more source