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Sequelae and Animal Modeling of Encephalitic Alphavirus Infections
Viruses, 2023 Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe encephalitic disease, resulting in myriad severe neurologic sequelae for which there are no vaccines or ...
Rachel A. Reyna, Scott C. Weaver
openaire +3 more sources
Cells, 2021 Alphaviruses are a group of arboviruses that generate chronic inflammatory rheumatisms in humans. Currently, no approved vaccines or antiviral therapies are available to prevent or treat alphavirus-induced diseases.
Anthony Dobi +3 more
doaj +1 more source
Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection [PDF]
Frontiers in Microbiology, 2017 Takaaki Koma +2 more
exaly +2 more sources
Effect of alphavirus infection on mouse embryos [PDF]
Infection and Immunity, 1982 Seven strains and mutants of the alphaviruses, Semliki Forest virus and Sindbis virus, differed in their lethality for mouse embryos and their mothers. The A7 strain and the neurovirulence mutant M103 of Semliki Forest virus were selected for detailed comparison. A7 produced 100% lethality of mouse embryos but was avirulent for their mothers.
Atkins, G J, Carter, J, Sheahan, B J
openaire +2 more sources
Proposed model for eEF2 phosphorylation during alphavirus infection. [PDF]
, 2023 The NTPase activity of alphavirus nsP2 induces an increase in the intracellular cAMP concentration which results in activation of PKA and increased eEF2K activity, increased phosphorylation of eEF2 on T56 and T58 and inhibition of translation which ...
Emmely E. Treffers (14684862) +6 more
core +1 more source
DDX56 Binds to Chikungunya Virus RNA To Control Infection
mBio, 2020 DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense.
Frances Taschuk +3 more
doaj +1 more source
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses [PDF]
Viruses, 2016 Gorben Pijlman +2 more
exaly +2 more sources
Neurological Sequelae Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2016 The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA viruses in the Togaviridae family.
Ronca SE, Dineley KT, Paessler S.
europepmc +4 more sources
Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]
, 2007 Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K +11 more
core +1 more source
First Record of Mosquito-Borne Kyzylagach Virus in Central Europe
Viruses, 2020 RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová +8 more
doaj +1 more source